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Opioids & SU

The Literature Collection contains over 11,000 references for published and grey literature on the integration of behavioral health and primary care. Learn More

Use the Search feature below to find references for your terms across the entire Literature Collection, or limit your searches by Authors, Keywords, or Titles and by Year, Type, or Topic. View your search results as displayed, or use the options to: Show more references per page; Sort references by Title or Date; and Refine your search criteria. Expand an individual reference to View Details. Full-text access to the literature may be available through a link to PubMed, a DOI, or a URL. References may also be exported for use in bibliographic software (e.g., EndNote, RefWorks, Zotero).

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13017 Results
10201
Rural‐urban differences in hospitalizations for opioid use‐associated infective endocarditis in Kentucky, 2016‐2019
Type: Journal Article
Authors: Kamran Siddiqi, Patricia R. Freeman, Laura C. Fanucchi, Svetla Slavova
Year: 2022
Topic(s):
Healthcare Disparities See topic collection
10202
Rural–urban differences in mental health and psychotherapy use among veterans with military sexual trauma: A retrospective cohort study
Type: Journal Article
Authors: Derrecka M. Boykin, Laura Haney, Amber B. Amspoker, Annette Walder, Natalie Hundt
Year: 2025
Topic(s):
Healthcare Disparities See topic collection
10203
Rurality and the opioid crisis in U.S. counties: A spatiotemporal investigation
Type: Web Resource
Authors: Feinuo Sun
Year: 2022
Topic(s):
Grey Literature See topic collection
,
Healthcare Disparities See topic collection
,
Opioids & Substance Use See topic collection
Disclaimer:

This grey literature reference is included in the Academy's Literature Collection in keeping with our mission to gather all sources of information on integration. Grey literature is comprised of materials that are not made available through traditional publishing avenues. Often, the information from unpublished resources can be limited and the risk of bias cannot be determined.

10204
Rx Awareness
Type: Report
Authors: Centers for Disease Control and Prevention
Year: 2018
Topic(s):
Grey Literature See topic collection
,
Opioids & Substance Use See topic collection
Disclaimer:

This grey literature reference is included in the Academy's Literature Collection in keeping with our mission to gather all sources of information on integration. Grey literature is comprised of materials that are not made available through traditional publishing avenues. Often, the information from unpublished resources can be limited and the risk of bias cannot be determined.

10205
Rx Pain Medications: Know the Options, Get the Facts
Type: Government Report
Authors: Centers for Disease Control and Prevention, Substance Abuse and Mental Health Services Administration
Year: 2017
Publication Place: Rockville, MD
Topic(s):
Grey Literature See topic collection
,
Opioids & Substance Use See topic collection
Disclaimer:

This grey literature reference is included in the Academy's Literature Collection in keeping with our mission to gather all sources of information on integration. Grey literature is comprised of materials that are not made available through traditional publishing avenues. Often, the information from unpublished resources can be limited and the risk of bias cannot be determined.

10206
Safe Babies Safe Moms Women's and Infants' Services Perinatal Mental Health and Wellness Program: A Comprehensive Integrated Model for Prevention and Treatment
Type: Journal Article
Authors: E. E. Asegieme, A. L. Danielson, A. L. Tobón, E. S. Rindner, Y. Xiong, P. B. Tanjutco, M. G. Biel, L. Patchen
Year: 2026
Abstract:

The Safe Babies Safe Moms Women's and Infants' Services Perinatal Mental Health and Wellness Program offers screening, assessment, prevention, and treatment options, as well as referrals, for complex care needs using an integrated collaborative care framework. Group and individual therapy options are available, leveraging both office-based and telehealth options. The article details the program's framework for services, describes the care team and program workflow, and summarizes program activities. In calendar year 2024, 3383 screenings using the Edinburgh Postnatal Depression Scale were completed for 1914 unique patients. Perinatal social workers conducted 1328 care coordination visits and completed 148 perinatal mental health assessments for elevated screenings. Integrated therapeutic services reached 220 people, and 53 were referred to psychiatry for complex care needs. The strengths of this program stem from early initiation of screening, multiple screenings throughout the perinatal period, care coordination for social services interventions, and a shared-decision-making process centered around the patients' needs and goals for perinatal mental health care. This integrated mental health model establishes a distinct, well-defined, yet dynamic pathway to provide screening, care coordination, and interventions for both prevention and treatment to optimize perinatal mental health outcomes. Evaluation of program outcomes is ongoing.

Topic(s):
Healthcare Disparities See topic collection
10207
Safe opioid prescribing: A community-based approach
Type: Journal Article
Authors: Sal Volpe, Joseph Conte
Year: 2021
Topic(s):
Education & Workforce See topic collection
,
Opioids & Substance Use See topic collection
10209
Safety and danger: Perceptions of the implementation of harm reduction programs in two communities in Nova Scotia, Canada
Type: Journal Article
Authors: Lois A. Jackson, Margaret Dechman, Holly Mathias, Jacqueline Gahagan, Kirk Morrison
Year: 2021
Topic(s):
Education & Workforce See topic collection
,
Opioids & Substance Use See topic collection
10210
Safety and Efficacy of Buprenorphine-Naloxone in Pregnancy: A Systematic Review of the Literature
Type: Journal Article
Authors: A. Ordean, M. Tubman-Broeren
Year: 2023
Abstract:

The prevalence of opioid use among pregnant people has been increasing over the past few decades, with a parallel increase in the rate of neonatal abstinence syndrome. Opioid agonist treatment (OAT) including methadone and buprenorphine is the recommended management method for opioid use disorders during pregnancy. Methadone has been extensively studied during pregnancy; however, buprenorphine was introduced in the early 2000s with limited data on the use of different preparations during pregnancy. Buprenorphine-naloxone has been incorporated into routine practice; however, only a few studies have investigated the use of this medication during pregnancy. To determine the safety and efficacy of this medication, we conducted a systematic review of maternal and neonatal outcomes among buprenorphine-naloxone-exposed pregnancies. The primary outcomes of interest were birth parameters, congenital anomalies, and severity of neonatal abstinence syndrome. Secondary maternal outcomes included the OAT dose and substance use at delivery. Seven studies met the inclusion criteria. Buprenorphine-naloxone doses ranged between 8 and 20 mg, and there was an associated reduction of opioid use during pregnancy. There were no significant differences in gestational age at delivery, birth parameters, or prevalence of congenital anomalies between buprenorphine-naloxone-exposed neonates and those exposed to methadone, buprenorphine monotherapy, illicit opioids, or no opioids. In studies comparing buprenorphine-naloxone to methadone, there were reduced rates of neonatal abstinence syndrome requiring pharmacotherapy. These studies demonstrate that buprenorphine-naloxone is a safe and effective opioid agonist treatment for pregnant people with OUD. Further large-scale, prospective data collection is required to confirm these findings. Patients and clinicians may be reassured about the use of buprenorphine-naloxone during pregnancy.

Topic(s):
Opioids & Substance Use See topic collection
,
Healthcare Disparities See topic collection
10211
Safety and Efficacy of Exposure-Based Risk Reduction Through Family Therapy for Co-occurring Substance Use Problems and Posttraumatic Stress Disorder Symptoms Among Adolescents: A Randomized Clinical Trial
Type: Journal Article
Authors: C. K. Danielson, Z. Adams, M. R. McCart, J. E. Chapman, A. J. Sheidow, J. Walker, A. Smalling, M. A. de Arellano
Year: 2020
Abstract: IMPORTANCE: No empirically supported treatments have been evaluated to address co-occurring substance use problems (SUP) and posttraumatic stress disorder (PTSD) symptoms among adolescents in an integrative fashion. This lack is partially owing to untested clinical lore suggesting that delivery of exposure-based PTSD treatments to youth with SUP might be iatrogenic. OBJECTIVE: To determine whether an exposure-based, integrative intervention for adolescents with SUP and PTSD symptoms-risk reduction through family therapy (RRFT)-resulted in improved outcomes relative to a treatment-as-usual (TAU) control condition consisting primarily of trauma-focused cognitive behavioral therapy. DESIGN, SETTING, AND PARTICIPANTS: This randomized clinical trial enrolled 124 participants who were recruited from November 1, 2012, through January 30, 2017. Adolescents (aged 13-18 years) who engaged in nontobacco substance use at least once during the past 90 days, experienced at least 1 interpersonal traumatic event, and reported 5 or more PTSD symptoms were enrolled. Blinded assessments were collected at baseline and at 3, 6, 12, and 18 months after baseline. Recruitment and treatment took place in community-based child advocacy centers in the Southeastern United States. Data were analyzed from August 2 through October 4, 2018, and were based on intention to treat. INTERVENTIONS: Participants were randomized to receive RRFT (n = 61) or TAU (n = 63). MAIN OUTCOMES AND MEASURES: Primary outcomes focused on number of nontobacco substance-using days measured with the timeline follow-back method and PTSD symptom severity using the UCLA (University of California, Los Angeles) PTSD Reaction Index for DSM-IV completed by adolescents and caregivers. Secondary outcomes focused on marijuana, alcohol, and polysubstance use and PTSD criterion standard (re-experiencing, avoidance, and hyperarousal) symptom severity. RESULTS: In all, 124 adolescents (mean [SD] age, 15.4 [1.3] years; 108 female [87.1%]) were randomized. For primary outcomes relative to TAU, RRFT yielded significantly greater reductions in substance-using days from baseline to month 12 (event rate [ER], 0.28; 95% CI, 0.12-0.65) and month 18 (ER, 0.10; 95% CI, 0.04-0.24). Significant reductions in PTSD symptoms were observed within groups for RRFT from baseline to months 3 (β = -9.25; 95% CI, -12.95 to -5.55), 6 (β = -16.63; 95% CI = -20.40 to -12.87), 12 (β = -17.51; 95% CI, -21.62 to -13.40), and 18 (β = -19.02; 95% CI, -23.07 to -14.96) and for TAU from baseline to months 3 (β = -9.62; 95% CI, -13.16 to -6.08), 6 (β = -13.73; 95% CI, -17.43 to -10.03), 12 (β = -15.53; 95% CI, -19.52 to -11.55), and 18 (β = -13.88; 95% CI, -17.69 to -10.09); however, between-group differences were not observed. CONCLUSIONS AND RELEVANCE: In this study, RRFT and TAU demonstrated within-group improvements in SUP and PTSD symptoms, with greater improvement for substance use and PTSD avoidance and hyperarousal symptoms among adolescents randomized to RRFT compared with TAU. No evidence of the worsening of SUP was observed in either condition. These results suggest that this exposure-based treatment is safe, feasibly delivered by community-based clinicians, and offers an effective approach to inform clinical practice. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT01751035.
Topic(s):
Opioids & Substance Use See topic collection
,
Healthcare Disparities See topic collection
10212
Safety and efficacy of long-term buprenorphine maintenance treatment.
Type: Journal Article
Authors: Ayman Fareed, Sreedevi Vayalapalli, Johnita Byrd-Sellers, Jennifer Casarella, Karen Drexler
Year: 2011
Topic(s):
Opioids & Substance Use See topic collection
10213
Safety and Tolerability of a Brief Cognitive-Behavioral Therapy for Chronic Pain Group for Veterans at Increased Risk for Suicide
Type: Journal Article
Authors: A. Martinson, E. M. Roberge, S. Wong, R. Pruitt, J. Perkins, J. Clinton-Lont
Year: 2025
Abstract:

INTRODUCTION: Chronic pain is a significant risk factor for suicide, especially among Veterans. The aim of this study is to evaluate the safety (i.e., the occurrence of suicidal behavior after treatment) and tolerability (i.e., treatment completion) of a Brief Cognitive-Behavioral Therapy for Chronic Pain (Brief CBT-CP) group in primary care among a sample of Veterans with chronic noncancer pain deemed to be at an increased risk for suicide. MATERIALS AND METHODS: Chart review was used to assess suicide history and treatment completion among Veterans who participated in a Brief CBT-CP group within a Primary Care-Mental Health Integration Clinic at a Veteran Affairs Medical Center. Suicide risk was stratified into 3 categories: Minimal (no current suicidal ideation or history of suicidal behavior), Elevated (current suicidal ideation or history of suicidal behavior), and High Risk (current suicidal ideation and history of suicidal behavior). Safety was assessed as the absence of suicidal behavior during and after Brief CBT-CP sessions. Tolerability was defined as completion of at least 4/6 sessions. RESULTS: Of the 261 Veterans who participated in a Brief CBT-CP group, 24.9% of Veterans were identified to be at Elevated Risk for suicide, and 1.5% of Veterans were identified to be at High Risk. Brief CBT-CP was identified as safe, as no deaths (by suicide or otherwise) or suicidal behaviors were observed while Veterans engaged in the treatment sessions. In fact, following completion of Brief CBT-CP, a 24.2% reduction in relative risk of suicidal behaviors was observed in the overall sample. Brief CBT-CP was also tolerable, with nearly 90% of Veterans completing at least 4 sessions (n = 229). CONCLUSIONS: Brief CBT-CP appears to be a safe and well-tolerated treatment for Veterans with chronic noncancer pain who are also at risk for suicide.

Topic(s):
Education & Workforce See topic collection
10214
Safety of a Rapidly Dissolving Buprenorphine/Naloxone Sublingual Tablet (BNX-RDT) for Treatment of Opioid Dependence: A Multicenter, Open-label Extension Study
Type: Journal Article
Authors: K. Hoffman, M. L. Peyton, M. Sumner
Year: 2017
Publication Place: United States
Abstract: OBJECTIVE: To assess the safety of rapidly dissolving buprenorphine/naloxone sublingual tablets (BNX-RDT) in opioid-dependent patients. METHODS: This open-label, 24-week extension study enrolled patients who completed primary trials of BNX-RDT. Daily tablet doses ranged from 5.7 to 17.1 mg. The primary endpoint was safety; secondary assessments included opioid cravings, addiction severity, health-related quality of life (QOL), and workplace productivity at screening (final day of the primary trials) through study end, with changes measured from baseline of the primary trials. RESULTS: In all, 665 patients received treatment; 292 (43.9%) completed the study. A total of 258 patients (38.8%) reported 557 treatment-emergent adverse events, most commonly headache (3.2%) and constipation (3.0%). Craving scores showed continued improvement on 100-mm visual analog scale (mean change from primary trial baseline, -52.8 at screening; mean change from extension trial baseline, -60.5 at week 24). Reductions in addiction severity from baseline of both the primary and extension trial were maintained through week 24 on multiple assessments, as were improvements in QOL on Short Form 36. Employment increased by 15% and mean (SD) hours worked per week increased by 4.6 (20.1) from baseline to study end. Mean (SD) scores for impact of opioid dependence on work productivity improved from 4.7 (3.0) at baseline to 0.9 (1.8) at study end (11-point scale). CONCLUSIONS: Extended treatment with BNX-RDT demonstrated a safety profile similar to other BNX formulations, reduced opioid cravings, and improved both QOL and work productivity. Continued treatment may enable patients to advance in recovery and return to normal functioning.
Topic(s):
Opioids & Substance Use See topic collection
10215
Safety of a Rapidly Dissolving Buprenorphine/Naloxone Sublingual Tablet (BNX-RDT) for Treatment of Opioid Dependence: A Multicenter, Open-label Extension Study
Type: Journal Article
Authors: K. Hoffman, M. L. Peyton, M. Sumner
Year: 2017
Publication Place: United States
Abstract: OBJECTIVE: To assess the safety of rapidly dissolving buprenorphine/naloxone sublingual tablets (BNX-RDT) in opioid-dependent patients. METHODS: This open-label, 24-week extension study enrolled patients who completed primary trials of BNX-RDT. Daily tablet doses ranged from 5.7 to 17.1 mg. The primary endpoint was safety; secondary assessments included opioid cravings, addiction severity, health-related quality of life (QOL), and workplace productivity at screening (final day of the primary trials) through study end, with changes measured from baseline of the primary trials. RESULTS: In all, 665 patients received treatment; 292 (43.9%) completed the study. A total of 258 patients (38.8%) reported 557 treatment-emergent adverse events, most commonly headache (3.2%) and constipation (3.0%). Craving scores showed continued improvement on 100-mm visual analog scale (mean change from primary trial baseline, -52.8 at screening; mean change from extension trial baseline, -60.5 at week 24). Reductions in addiction severity from baseline of both the primary and extension trial were maintained through week 24 on multiple assessments, as were improvements in QOL on Short Form 36. Employment increased by 15% and mean (SD) hours worked per week increased by 4.6 (20.1) from baseline to study end. Mean (SD) scores for impact of opioid dependence on work productivity improved from 4.7 (3.0) at baseline to 0.9 (1.8) at study end (11-point scale). CONCLUSIONS: Extended treatment with BNX-RDT demonstrated a safety profile similar to other BNX formulations, reduced opioid cravings, and improved both QOL and work productivity. Continued treatment may enable patients to advance in recovery and return to normal functioning.
Topic(s):
Opioids & Substance Use See topic collection
10216
Safety profile of injectable hydromorphone and diacetylmorphine for long-term severe opioid use disorder
Type: Journal Article
Authors: Eugenia Oviedo-Joekes, Suzanne Brissette, Scott MacDonald, Daphne Guh, Kirsten Marchand, Salima Jutha, Scott Harrison, Amin Janmohamed, Derek Z. Zhang, Aslam H. Anis, Michael Krausz, David C. Marsh, Martin T. Schechter
Year: 2017
Topic(s):
Opioids & Substance Use See topic collection
10217
Safety-Net Leadership Perspectives on Collaborative Care for Children With Developmental Disabilities
Type: Journal Article
Authors: A. P. Srinivasan, M. Venegas, R. S. Akins, Garcia E. Fernandez, A. C. Stahmer
Year: 2026
Abstract:

OBJECTIVE: To identify key barriers and facilitators to designing and implementing collaborative care (CC) for children with developmental disabilities (DD) in safety-net primary care. METHODS: This pre-implementation qualitative study involved semi-structured interviews with safety-net primary care leaders. Using purposive and respondent-driven sampling, interviews were conducted with 16 leaders across 9 safety-net organizations in Northern California between August 2024 and January 2025. Key Consolidated Framework for Implementation Research (CFIR) constructs guided data collection. Data were analyzed using the Rapid Assessment Process and validated through structured member checking. RESULTS: Leaders from 8 of 9 organizations reported existing integrated behavioral health programs staffed by mental health counselors and/or psychiatrists, but nearly all noted that these programs did not address the specific needs of children with DD. When asked about developing a CC intervention for this population, leaders identified implementation barriers and facilitators that mapped to CFIR inner and outer setting domains. Four themes were distilled: inner setting barriers (space and cost), inner setting facilitators (perceived clinical need among leadership), outer setting barriers (restrictive Medicaid reimbursement policies and limited performance measurement pressure), and outer setting facilitators (alternative financing mechanisms). CONCLUSION: Safety-net leaders indicate a clinical need for CC models specifically for children with DD, but implementation success will depend on addressing space, financing, and policy barriers through targeted implementation strategies.

Topic(s):
Education & Workforce See topic collection
,
Healthcare Disparities See topic collection
10218
Safety-Net Providers In Some US Communities Have Increasingly Embraced Coordinated Care Models
Type: Journal Article
Authors: P. Cunningham, L. Felland, L. Stark
Year: 2012
Topic(s):
General Literature See topic collection
10219
SAGE & THYME: A model for training health and social care professionals in patient-focussed support
Type: Journal Article
Authors: M. Connolly, J. Perryman, Y. McKenna, J. Orford, L. Thomson, J. Shuttleworth, S. Cocksedge
Year: 2010
Publication Place: Ireland
Abstract: OBJECTIVE: To develop a model for addressing the emotional concerns of patients or their caregivers; to teach the model in a three-hour workshop and to assess the impact of that training on a wide range of health and social care staff. METHODS: A multi-specialty team, including a cancer patient, developed a model based on the evidence relating to emotional support and communication skills. The model (SAGE & THYME) consists of nine steps (see Box 1). The purpose of the model is to enable staff of all grades and roles to fulfil the most important objectives of support: enabling patients to describe their concerns and emotions if they wish to do so, holding and respecting those concerns; identifying the patients' support structures; exploring the patients' own ideas and solutions before offering advice or information. Over 800 health and social care staff of all grades and students have participated in the three-hour SAGE & THYME training workshops. RESULTS: Analysis from 412 participants suggests that the workshops had a significant positive effect on self-confidence (p<.0005), self-perception of competence (p<.0005) and willingness to explore the emotional concerns of patients (p<.0005). 95% felt that the workshop would be very likely to have an impact on their practice. CONCLUSIONS: The workshops have been successful in increasing the self-perceptions of confidence, competence and willingness to explore the emotional concerns of patients. The model 'SAGE & THYME' has been welcomed by participants. PRACTICE IMPLICATIONS: Staff groups will require training for patients or their caregivers to have their concerns heard without interruption and to be allowed to explore their own resolutions. The three-hour SAGE & THYME training may go some way towards helping patients and staff form sound partnerships which assist patients to participate constructively in their own care.
Topic(s):
Education & Workforce See topic collection
10220
Same goal, different perspectives: Stakeholder views on context for connected care technology implementation in an integrated healthcare system
Type: Journal Article
Authors: S. A. Robinson, J. M. Lipschitz, N. Ndiwane, F. R. Bixler, B. Etingen, M. S. Zocchi, S. L. Shimada, J. A. Palmer, T. J. Newton, N. Shah, T. P. Hogan
Year: 2025
Abstract:

IntroductionThe Veterans Health Administration (VHA) prioritizes use of connected care technologies to enhance access and outcomes. The context in which connected care is implemented is crucial, yet difficult to measure, due to its subjective and complex nature. This evaluation examined alignment among stakeholder perceptions of context related to connected care implementation across VHA.MethodsA national, cross-sectional survey assessed perceptions of 11 contextual factors relevant to connected care implementation as identified in published reviews within the implementation science literature. Across 142 VHA facilities and 18 regions, surveys were sent to four stakeholder groups: clinical team members, connected care coordinators, facility leadership, and regional leadership. Mean scores for each factor were compared between stakeholder groups using Welch's ANOVA and Bonferroni-corrected post-hoc comparisons.ResultsA total of 5541 respondents (36.1% response rate) participated. Organizational Culture and Climate was rated the most favorable contextual factor (mean = 3.9, SD = 0.7), while Financial Resources was perceived as least favorable (mean = 3.0, SD = 1.0). Significant differences emerged between the perceptions of frontline workers (clinical team members, connected care coordinators) and leadership (facility, regional). Clinical team members rated nearly all contextual factors less favorably than facility leadership. Coordinators similarly rated most factors less favorably than leadership.DiscussionFindings highlight a misalignment between leadership and frontline workers in their perceptions of organizational context for implementing connected care technologies. Leadership viewed key contextual factors (e.g. Organizational Readiness to Change, Leadership Support) more favorably than frontline workers. This misalignment may impact implementation success, suggesting a need for strategies to better align stakeholder perceptions.

Topic(s):
HIT & Telehealth See topic collection