Literature Collection

BACKGROUND: Opioid use disorders are a major medical and public health concern. Buprenorphine is approved for the treatment of opioid use disorders; however, a shortage of physicians prescribing buprenorphine is a significant barrier to treatment access. The aims of this study were to evaluate opinions of internal medicine attending and resident physicians about buprenorphine and assess interest in becoming waivered to prescribe. METHODS: Internal medicine resident and attending physicians at a primary care clinic in a large academic hospital were invited to complete surveys. The study sample was composed of physicians who were not waivered to prescribe buprenorphine. Survey data included demographic information, level of training, buprenorphine waiver status, interest in becoming waivered to prescribe buprenorphine, and beliefs about buprenorphine for treatment of opioid use disorders. High interest in becoming waivered was defined as a Likert response >3 (1 = No interest, 5 = Very interested). RESULTS: Of the 44 physician respondents, 39 were not waivered to prescribe buprenorphine and constituted the sample; of those, 27 were residents and 12 were attending physicians. Twenty-six of the 39 nonwaivered respondents (66.7%) had high interest in becoming waivered. Those with high interest in becoming waivered were significantly more likely to be younger (P = .007) and to strongly believe in buprenorphine effectiveness (P = .023). DISCUSSION: Most physicians in this academic training program showed high interest in prescribing buprenorphine, and belief in buprenorphine effectiveness was associated with high interest in becoming waivered.

INTRODUCTION: Treatment for opioid use disorder (OUD) with diacetylmorphine is an evidence-based form of drug treatment, but it is not available in the United States (US). Better understanding acceptability of treatment with injectable diacetylmorphine among people who use opioids (PWUO) in the US may expedite future initiatives designed to engage persons in this form of treatment should it become available. The purpose of this research is to examine factors associated with interest in treatment with injectable diacetylmorphine among a sample of PWUO in the US. METHODS: Data are from a cross-sectional study of PWUO in Baltimore City, Maryland. Participants were given a brief description of treatment with injectable diacetylmorphine and then asked to rate their level of interest. We used Poisson regression with robust variance to assess factors associated with interest in treatment with injectable diacetylmorphine. RESULTS: The average age of participants was 48 years, 41% were women, and most (76%) identified as non-Hispanic, Black. The most commonly used substances were non-injection heroin (76%), opioid pain relievers (73%), and non-injection crack/cocaine (73%). Two-thirds of participants (68%) indicated interest in treatment with injectable diacetylmorphine. Factors significantly associated with interest in injectable diacetylmorphine treatment included: having at least a high school education (adjusted prevalence ratio [aPR]: 1.23; 95% confidence interval [CI]: 1.04-1.45), not having health insurance (aPR: 1.23; 95% CI: 1.06-1.44), having ever overdosed (aPR: 1.20; 95% CI: 1.01-1.42), and past utilization of medications for opioid use disorder (aPR: 1.22; 95% CI: 1.01-1.47). Recent non-injection cocaine use was inversely associated with interest in treatment with injectable diacetylmorphine (aPR 0.80; 95% CI: 0.68-0.94). CONCLUSION: The majority of participants reported interest in treatment with injectable diacetylmorphine. Given worsening trends in the addiction and overdose crisis in the US, treatment with injectable diacetylmorphine should be considered as another evidence-based option for treating OUD.KEY MESSAGESInterest in treatment with injectable diacetylmorphine was high among a sample of people who use opioids in the United States.Factors associated with increased interest in treatment with injectable diacetylmorphine included having at least a high school education, having ever overdosed, and not having health insurance.Past utilization of medications for opioid use disorder was associated with interest in treatment with injectable diacetylmorphine.

Medications for opioid use disorder (MOUD) remain highly inaccessible despite demonstrated effectiveness. We examine the extent of screening for opioid use and availability of MOUD in a national cross-section of multi-physician primary care and multispecialty practices. Drawing on an existing framework to characterize the internal and environmental context, we assess socio-technical, organizational-managerial, market-based, and state-regulation factors associated with the use of opioid screening and offering of MOUD in a practice. A total of 26.2% of practices offered MOUD, while 69.4% of practices screened for opioid use. Having advanced health information technology functionality was positively associated with both screening for opioid use and offering MOUD in a practice, while access to on-site behavioral clinicians was positively associated with offering MOUD in adjusted models. These results suggest that improving access to information and expertise may enable physician practices to respond more effectively to the nation's ongoing opioid epidemic.

BACKGROUND: Perinatal mental illnesses (PMI) affect up to 20% of women and 10% of men during pregnancy and in the first year after the birth of the child. Perinatal mental illness contributes significantly to maternal mortality and adverse neonatal, infant, and child outcomes. Because of the high prevalence and the impact of PMI on both the parents and the infant, there is an urgent need for rapid and effective care. The aim of this scoping review was to identify comprehensive evidence-based guidelines and care models for the prevention and treatment of PMI and summarize their common characteristics. METHODS: We searched manually in several databases and on websites of relevant institutions and contacted experts. We included guidelines and guidance documents based on pre-defined inclusion criteria. RESULTS: We identified six relevant guidelines and care models from four countries (United Kingdom, Ireland, Canada, Australia). The identified documents highlight the need for integrated care models (including prevention, early identification, counseling, treatment), clear referral pathways, stepped-care approaches and multi-professional, coordinated networks. CONCLUSIONS: The 'ideal' care model should consider not only the mental health of the mother, but also that of the father/co-parent and the children, as well as the parent-infant relationship. The results from this scoping review can be used for further discussion and as decision support for designing, developing, and implementing perinatal and infant mental health (PIMH) care.

BACKGROUND: While the associations between coronary heart disease (CHD) and depression are well-documented, their synergistic interplay requires quantification in large, representative populations. Operating within a cross-sectional framework, this study’s objective was to investigate the associations of CHD and depression with current health status and to explore their interaction using a nationally representative U.S. sample. METHODS: This study utilized data from 172,741 participants in the 2022 Behavioral Risk Factor Surveillance System (BRFSS). CHD and depression were based on self-reported history. Outcomes were frequent physical and mental distress (≥ 14 unhealthy days in the past 30 days). We used multivariable logistic regression with inverse probability of treatment weighting (IPTW) to adjust for confounding and estimate adjusted odds ratios (aORs) with 95% confidence intervals (CIs). An exploratory analysis assessed the extent to which the association between CHD and health status was statistically explained by depression, and additive interaction was also examined. RESULTS: After IPTW adjustment, CHD was significantly associated with a higher likelihood of both frequent physical distress (aOR = 1.47, 95% CI: 1.35–1.60) and frequent mental distress (aOR = 2.59, 95% CI: 2.44–2.75). Depression statistically explained 2.19% of the association between CHD and poor physical health and 21.69% of the association with poor mental health. A significant positive additive interaction was found between CHD and depression. The synergy index indicated that their combined association with poor physical health was 1.26 times greater, and with poor mental health was 1.40 times greater, than the sum of their individual associations. CONCLUSION: In a large U.S. adult sample, CHD and depression are independently and synergistically associated with poorer physical and mental health. These findings underscore the importance of integrated care models that address both conditions to improve patient well-being. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12889-026-26334-3.