Literature Collection

5141

Heroin or conventional opioid maintenance? The patients' perspective

Type: Journal Article

Authors: L. K. Bald, F. Bermpohl, A. Heinz, J. Gallinat, S. Gutwinski

Year: 2013

Publication Place: United States

Abstract: OBJECTIVE: This study focused on the question whether patients with conventional opioid maintenance treatment (COMT) would prefer a switch to heroin maintenance treatment (HMT). METHODS: We performed a region-wide anonymous survey of patients in the opioid maintenance program in Berlin, Germany. All 20 psychiatric hospitals and all 110 physicians' practices in Berlin licensed to offer COMT were approached to reach patients under COMT and also fulfilling the Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition) criteria of opiate dependence. The anonymous questionnaire focused on the question whether patients would prefer HMT to COMT. In our study, 986 of 5032 patients (19.6%) with COMT in Berlin participated. Of them, 881 (89.4%) patients gave information whether they would prefer HMT to COMT. RESULTS: Of the participating patients, 40.9% would prefer HMT to COMT. These patients report more detoxification therapies (P < 0.001), a higher dose of methadone equivalent (P = 0.001), and more often continued use of multiple illegal drugs despite COMT (P < 0.001) than patients not preferring HMT. They also report less improvement in mental health (P < 0.001) and working abilities (P < 0.001) because of COMT than patients not preferring HMT. CONCLUSIONS: The data on the patients' perspective complement the existing clinical studies, showing that previously unresponsive opioid-addicted patients especially would switch to HMT, whereas most patients would prefer continuation of COMT.

Topic(s):

Reference Links:

Export Citation: RIS

View details

5142

Heroin uncertainties: Exploring users' perceptions of fentanyl-adulterated and -substituted 'heroin'

Type: Journal Article

Authors: D. Ciccarone, J. Ondocsin, S. G. Mars

Year: 2017

Publication Place: Netherlands

Topic(s):

Reference Links:

Export Citation: RIS

View details

5143

Heterogeneity in the Development of Drug Use Versatility: Risk Factors for Polydrug Use throughout the Life-Course

Type: Journal Article

Authors: Thomas W. Wojciechowski

Year: 2019

Publication Place: Philadelphia

Topic(s):

, ,

Reference Links:

Export Citation: RIS

View details

5144

Heterogeneity of nonadherent buprenorphine patients: subgroup characteristics and outcomes

Type: Journal Article

Authors: C. Ruetsch, J. Tkacz, V. R. Nadipelli, B. L. Brady, N. Ronquest, H. Un, J. Volpicelli

Year: 2017

Publication Place: United States

Abstract: OBJECTIVES: To examine patient characteristics and outcomes associated with nonadherence to buprenorphine and to identify specific patterns of nonadherent behavior. STUDY DESIGN: Cross-sectional, retrospective analysis of health claims data. METHODS: Aetna's administrative claims data were used to categorize incident opioid use disorder (OUD) patients based on buprenorphine medication possession ratio (MPR) into adherent (n = 172) and nonadherent (n = 305) groups. Adherent groups were then divided into 5 subgroups based on level of MPR, as well as 2 a priori-defined groups: intermittent adherent (IA) and early treatment discontinuation-no consequences (ETDNC). Groups were compared on patient characteristics and outcomes. RESULTS: Nonadherent members incurred significantly greater healthcare costs and were more likely to relapse (P <.05). The use of high-cost healthcare services increased as a function of decreasing MPR (P <.05). Assessment of the a priori groups revealed IA members to have outcomes similar to nonadherent patients, while ETDNC members exhibited outcomes similar to adherent members. CONCLUSIONS: Administrative claims can be used to define subgroups of buprenorphine-medication assisted treatment (B-MAT) patients. Nonadherence was related to an increased likelihood of relapse, and there is an inverse relationship between MPR and cost. The heterogeneity observed within this sample indicates that treatment regimens effective for 1 subgroup may not be appropriate for all OUD patients. Increased understanding of B-MAT nonadherent subgroups may facilitate development of new interventions and medications specifically designed for nonadherent B-MAT patients, potentially leading to improved outcomes and reduced costs of care.

Topic(s):

,

Reference Links:

Export Citation: RIS

View details

5145

Hey, Doc, Can We Cut Down on the Pain Pills? Current Status of Opioid Tapering Guidelines and How to Do It (SA525)

Type: Journal Article

Authors: Eric Prommer, Mary Lynn McPherson, Kathryn Walker, Mellar Davis

Year: 2017

Publication Place: Madison

Topic(s):

,

Export Citation: RIS

View details

5146

HHS Guide for Clinicians on the Appropriate Dosage Reduction or Discontinuation of Long-Term Opioid Analgesics

Type: Government Report

Authors: Department of Health and Human Services

Year: 2019

Topic(s):

, ,

Disclaimer:

This grey literature reference is included in the Academy's Literature Collection in keeping with our mission to gather all sources of information on integration. Grey literature is comprised of materials that are not made available through traditional publishing avenues. Often, the information from unpublished resources can be limited and the risk of bias cannot be determined.

Access Resource

Reference Links: Access Resource

Export Citation: RIS

View details

5147

HHS Guide for Clinicians on the Appropriate Dosage Reduction or Discontinuation of Long-Term Opioid Analgesics

Type: Web Resource

Authors: Department of Health and Human Services

Year: 2019

Topic(s):

, ,

Disclaimer:

This grey literature reference is included in the Academy's Literature Collection in keeping with our mission to gather all sources of information on integration. Grey literature is comprised of materials that are not made available through traditional publishing avenues. Often, the information from unpublished resources can be limited and the risk of bias cannot be determined.; This grey literature reference is included in the Academy's Literature Collection in keeping with our mission to gather all sources of information on integration. Grey literature is comprised of materials that are not made available through traditional publishing avenues. Often, the information from unpublished resources can be limited and the risk of bias cannot be determined.

Access Resource

Reference Links: Access Resource

Export Citation: RIS

View details

5148

HHS Roadmap for Behavioral Health Integration Fact Sheet of Accomplishments

Type: Report

Authors: U.S. Department of Health and Human Services

Year: 2024

Publication Place: Washington, DC

Topic(s):

, , , , ,

Disclaimer:

This grey literature reference is included in the Academy's Literature Collection in keeping with our mission to gather all sources of information on integration. Grey literature is comprised of materials that are not made available through traditional publishing avenues. Often, the information from unpublished resources can be limited and the risk of bias cannot be determined.

Access Resource

Reference Links: Access Resource

Export Citation: RIS

View details

5149

HHS’s Strategic Approach to Addressing Social Determinants of Health to Advance Health Equity – At a Glance

Type: Web Resource

Authors: U.S. Department of Health and Human Services

Year: 2022

Publication Place: Washington, DC

Topic(s):

, ,

Disclaimer:

This grey literature reference is included in the Academy's Literature Collection in keeping with our mission to gather all sources of information on integration. Grey literature is comprised of materials that are not made available through traditional publishing avenues. Often, the information from unpublished resources can be limited and the risk of bias cannot be determined.

PDF (178 KB)

Reference Links: PDF (178 KB)

Export Citation: RIS

View details

5150

High Override Rate for Opioid Drug-allergy Interaction Alerts: Current Trends and Recommendations for Future

Type: Journal Article

Authors: M. Topaz, D. L. Seger, K. Lai, P. G. Wickner, F. Goss, N. Dhopeshwarkar, F. Chang, D. W. Bates, L. Zhou

Year: 2015

Publication Place: Netherlands

Abstract: This study examined trends in drug-allergy interaction (DAI) alert overrides for opioid medications - the most commonly triggered alerts in the computerized provider order entry (CPOE). We conducted an observational analysis of the DAI opioid alerts triggered over the last decade (2004-2013, n=342,338) in two large academic hospitals in Boston (United States). We found an increasing rate of DAI alert overrides culminating in 89.7% in 2013. Allergic reactions included a high proportion (38.2%) of non-immune mediated opioid reactions (e.g. gastrointestinal upset). The DAI alert override rate was high for immune mediated (88.6%) and life threatening reactions (87.8%). Exact allergy-medication matches were overridden less frequently (about 70%) compared to non-exact matches within allergy groups (over 90%). About one-third of the alert override reasons pointed to irrelevant alerts (i.e."Patient has tolerated the medication before") and 44.9% were unknown. Those findings warrant further investigation into providers' reasons for high override rate. User interfaces should evolve to enable less interruptive and more accurate alerts to decrease alert fatigue.

Topic(s):

,

Reference Links:

Export Citation: RIS

View details

5151

High Prevalence of Buprenorphine in Prenatal Drug Screens in an Appalachian City

Type: Journal Article

Authors: C. Alexander, K. Breuel, M. Olsen

Year: 2020

Publication Place: United States

Abstract:

OBJECTIVES: To define the magnitude of buprenorphine presence in the urine drug screens of pregnant women and to assess the presence of illicit buprenorphine use versus the presence of prescribed buprenorphine use. METHODS: Initial prenatal drug screen results for all pregnant patients in our practice for a 1-year period were analyzed and tabulated. RESULTS: Buprenorphine was found in the urine drug screens of 16% of pregnant patients. The presence of buprenorphine was by far the highest for any substance associated with neonatal abstinence syndrome (NAS). We estimate that the exposure to buprenorphine of approximately one-third of individuals in our population is associated with illicit buprenorphine use. CONCLUSIONS: The high rate of NAS in our region is primarily associated with both illicit and prescribed buprenorphine rather than other substances. Buprenorphine usage at the time that prenatal care is initiated, rather than opiate use at the onset of prenatal care, is the underlying factor that must be addressed if our region is to successfully combat our high rates of NAS.

Topic(s):

,

Reference Links:

Export Citation: RIS

View details

5152

High prevalence of urine tampering in an office-based opioid treatment practice detected by evaluating the norbuprenorphine to buprenorphine ratio

Type: Journal Article

Authors: A. J. Accurso, J. D. Lee, J. McNeely

Year: 2017

Publication Place: United States

Topic(s):

Reference Links:

Export Citation: RIS

View details

5153

High Quality of Care Persists With Shifting Depression Services From VA Specialty to Integrated Primary Care

Type: Journal Article

Authors: L. B. Leung, J. J. Escarce, J. Yoon, C. A. Sugar, K. B. Wells, A. S. Young, L. V. Rubenstein

Year: 2019

Publication Place: United States

Topic(s):

Reference Links:

Export Citation: RIS

View details

5154

High throughput mu-SPE based elution coupled with UPLC-MS/MS for determination of eluxadoline in plasma sample: Application in pharmacokinetic characterization of PLGA nanoparticle formulations in rats

Type: Journal Article

Authors: M. Iqbal, E. Ezzeldin, K. A. Al-Rashood, R. Al-Shdefat, M. K. Anwer

Year: 2018

Publication Place: England

Topic(s):

Reference Links:

Export Citation: RIS

View details

5155

High willingness to use overdose prevention sites among suburban people who use drugs who do not inject

Type: Journal Article

Authors: K. E. Schneider, G. J. Urquhart, S. Rouhani, S. T. Allen, M. Morris, S. G. Sherman

Year: 2023

Topic(s):

,

Reference Links:

Export Citation: RIS

View details

5156

High willingness to use rapid fentanyl test strips among young adults who use drugs

Type: Journal Article

Authors: Maxwell S. Krieger, Jesse L. Yedinak, Jane A. Buxton, Mark Lysyshyn, Edward Bernstein, Josiah D. Rich, Traci C. Green, Scott E. Hadland, Brandon D. L. Marshall

Year: 2018

Topic(s):

Export Citation: RIS

View details

5157

High-deductible Health Plans and Nonfatal Opioid Overdose

Type: Journal Article

Authors: J. C. P. Eddelbuettel, C. L. Barry, A. Kennedy-Hendricks, A. B. Busch, M. A. G. Hollander, H. A. Huskamp, M. K. Meiselbach, C. Schilling, E. A. Stuart, M. D. Eisenberg

Year: 2023

Reference Links:

Export Citation: RIS

View details

5158

High-impact mental health - Primary care research for patients with multiple comorbidities.

Type: Journal Article

Authors: Susan T. Azrin

Year: 2014

Topic(s):

Export Citation: RIS

View details

5159

High-intensity cannabis use is associated with retention in opioid agonist treatment: a longitudinal analysis

Type: Journal Article

Authors: Maria Eugenia Socias, Evan Wood, Stephanie Lake, Seonaid Nolan, Nadia Fairbairn, Kanna Hayashi, Hennady P. Shulha, Seagle Liu, Thomas Kerr, M-J Milloy

Year: 2018

Publication Place: England

Topic(s):

,

Reference Links:

Export Citation: RIS

View details

5160

High-risk polysubstance use among LGBTQ+ people who use drugs in the United States: An application of syndemic theory

Type: Journal Article

Authors: Cory J. Cascalheira, Jessie Nelson, Ryan E. Flinn, Yuxuan Zhao, Emily C. Helminen, Jillian R. Scheer, Amy L. Stone

Year: 2023

Topic(s):

,

Access Resource

Reference Links: Access Resource

Export Citation: RIS

View details