TY - JOUR
KW - Analgesics, Opioid/therapeutic use
KW - Humans
KW - Opiate Substitution Treatment
KW - Opioid-Related Disorders/drug therapy
KW - Patient Discharge
KW - Treatment Outcome
KW - Care continuity
KW - Detoxification
KW - opioid use disorder
KW - Treatment engagement
AU - V. Ameral
AU - E. Hocking
AU - X. Leviyah
AU - N. G. Newberger
AU - C. Timko
AU - N. Livingston
A1 - 
AB - BACKGROUND: Inpatient detoxification is a common health care entry point for people with Opioid Use Disorder (OUD). However, many patients return to opioid use after discharge and also do not access OUD treatment. This systematic review reports on the features and findings of research on interventions developed specifically to improve substance use outcomes and treatment linkage after inpatient detoxification for OUD. METHODS: Of 6419 articles, 64 met inclusion criteria for the current review. Articles were coded on key domains including sample characteristics, study methods and outcome measures, bias indicators, intervention type, and findings. RESULTS: Many studies did not report sample characteristics, including demographics and co-occurring psychiatric and substance use disorders, which may impact postdetoxification OUD treatment outcomes and the generalizability of interventions. Slightly more than half of studies examined interventions that were primarily medical in nature, though only a third focused on initiating medication treatment beyond detoxification. Medical and combination interventions that focused on initiating medications for OUD generally performed well, as did psychological interventions with one or more reinforcement-based components. CONCLUSIONS: Research efforts to improve post-detoxification outcomes would benefit from clearer reporting of sample characteristics that are associated with treatment and recovery outcomes, including diagnostic comorbidities. Findings also support the need to identify ways to introduce medication for opioid use disorder (MOUD) and other effective treatments including reinforcement-based interventions during detoxification or soon after.
AD - VISN 1 Mental Illness Research, Education, and Clinical Center, VA Bedford Healthcare System, Bedford, MA, USA; Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA, USA. Electronic address: Victoria.Ameral@va.gov.; VA Boston Healthcare System, Boston, MA, USA.; National Center for PTSD, Behavioral Science Division, VA Boston Healthcare System, Boston, MA, USA.; National Center for PTSD, Behavioral Science Division, VA Boston Healthcare System, Boston, MA, USA.; VA Palo Alto Health Care System, Palo Alto, CA, USA; Stanford University School of Medicine, Stanford, CA, USA.; VA Boston Healthcare System, Boston, MA, USA; National Center for PTSD, Behavioral Science Division, VA Boston Healthcare System, Boston, MA, USA; Department of Psychiatry, Boston University School of Medicine, Boston, MA, USA.
BT - Drug and alcohol dependence
C5 - Opioids & Substance Use
CY - Ireland
DO - 10.1016/j.drugalcdep.2022.109379
JF - Drug and alcohol dependence
LA - eng
M1 - Journal Article
N2 - BACKGROUND: Inpatient detoxification is a common health care entry point for people with Opioid Use Disorder (OUD). However, many patients return to opioid use after discharge and also do not access OUD treatment. This systematic review reports on the features and findings of research on interventions developed specifically to improve substance use outcomes and treatment linkage after inpatient detoxification for OUD. METHODS: Of 6419 articles, 64 met inclusion criteria for the current review. Articles were coded on key domains including sample characteristics, study methods and outcome measures, bias indicators, intervention type, and findings. RESULTS: Many studies did not report sample characteristics, including demographics and co-occurring psychiatric and substance use disorders, which may impact postdetoxification OUD treatment outcomes and the generalizability of interventions. Slightly more than half of studies examined interventions that were primarily medical in nature, though only a third focused on initiating medication treatment beyond detoxification. Medical and combination interventions that focused on initiating medications for OUD generally performed well, as did psychological interventions with one or more reinforcement-based components. CONCLUSIONS: Research efforts to improve post-detoxification outcomes would benefit from clearer reporting of sample characteristics that are associated with treatment and recovery outcomes, including diagnostic comorbidities. Findings also support the need to identify ways to introduce medication for opioid use disorder (MOUD) and other effective treatments including reinforcement-based interventions during detoxification or soon after.
PP - Ireland
PY - 2022
SN - 1879-0046; 0376-8716
SP - 109379
T1 - Innovating for real-world care: A systematic review of interventions to improve post-detoxification outcomes for opioid use disorder
T2 - Drug and alcohol dependence
TI - Innovating for real-world care: A systematic review of interventions to improve post-detoxification outcomes for opioid use disorder
U1 - Opioids & Substance Use
U2 - 35255353
U3 - 10.1016/j.drugalcdep.2022.109379
VL - 233
VO - 1879-0046; 0376-8716
Y1 - 2022
Y2 - Apr 1
ER -