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Opioids & SU

The Literature Collection contains over 11,000 references for published and grey literature on the integration of behavioral health and primary care. Learn More

Use the Search feature below to find references for your terms across the entire Literature Collection, or limit your searches by Authors, Keywords, or Titles and by Year, Type, or Topic. View your search results as displayed, or use the options to: Show more references per page; Sort references by Title or Date; and Refine your search criteria. Expand an individual reference to View Details. Full-text access to the literature may be available through a link to PubMed, a DOI, or a URL. References may also be exported for use in bibliographic software (e.g., EndNote, RefWorks, Zotero).

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11202 Results
2381
Community‐based naloxone coverage equity for the prevention of opioid overdose fatalities in racial/ethnic minority communities in Massachusetts and Rhode Island
Type: Journal Article
Authors: Shayla Nolen, Xiao Zang, Avik Chatterjee, Czarina N. Behrends, Traci C. Green, Aranshi Kumar, Benjamin P. Linas, Jake R. Morgan, Sean M. Murphy, Alexander Y. Walley, Shapei Yan, Bruce R. Schackman, Brandon D. L. Marshall
Year: 2021
Topic(s):
Healthcare Disparities See topic collection
,
Opioids & Substance Use See topic collection
2382
Community‐based naloxone coverage equity for the prevention of opioid overdose fatalities in racial/ethnic minority communities in Massachusetts and Rhode Island
Type: Journal Article
Authors: Shayla Nolen, Xiao Zang, Avik Chatterjee, Czarina N. Behrends, Traci C. Green, Aranshi Kumar, Benjamin P. Linas, Jake R. Morgan, Sean M. Murphy, Alexander Y. Walley, Shapei Yan, Bruce R. Schackman, Brandon D. L. Marshall
Year: 2022
Topic(s):
Healthcare Disparities See topic collection
,
Opioids & Substance Use See topic collection
2383
CommunityStat: A public health intervention to reduce opioid overdose deaths in Burlington, Vermont, 2017–2020
Type: Journal Article
Authors: Brandon del Pozo
Year: 2022
Topic(s):
Opioids & Substance Use See topic collection
2384
Comorbid Chronic General Health Conditions and Depression Care: A Population-Based Analysis
Type: Journal Article
Authors: J. H. Puyat, A. Kazanjian, H. Wong, E. Goldner
Year: 2017
Publication Place: United States
Abstract: OBJECTIVE: Untreated depression among persons with chronic general health conditions (chronic health conditions) affects mortality, functional disability, quality of life, and health care costs. Currently, studies of the association between depression care and chronic health conditions report inconsistent results, and studies of depression care among persons with specific health conditions are rare. This study investigated the association between chronic health conditions and the likelihood of receiving depression care among individuals with depression. METHODS: Retrospective data from physician claims, hospital separations, vital statistics, and insurance plan registries were used to identify a cohort of individuals with depression and track 12-month use of health services among those with and without a chronic health condition. Disparities were analyzed by using generalized linear models. RESULTS: Individuals with depression and a chronic health condition had higher use of psychological therapy, higher use of any depression care, greater continuity of care, and better adherence to antidepressant therapy compared with individuals with depression only. However, they were less likely, in general, to be on antidepressant therapy, and individuals with diabetes had fewer visits to general practitioners for a mental health-related reason compared with individuals without diabetes. A trend toward lower use of any depression care was observed among patients with cerebrovascular disease. CONCLUSIONS: Use of depression care was generally higher among individuals with chronic health conditions, although there were differences in patterns of use by type of health condition. Some patients with specific health conditions could be at risk of being inappropriately treated for depression.
Topic(s):
Healthcare Disparities See topic collection
2385
Comorbid mental disorders account for the role impairment of commonly occurring chronic physical disorders: results from the National Comorbidity Survey
Type: Journal Article
Authors: Ronald C. Kessler, Johan Ormel, Olga Demler, Paul E. Stang
Year: 2003
Topic(s):
General Literature See topic collection
2386
Comorbid opioid use is undertreated among forensic patients with schizophrenia
Type: Journal Article
Authors: K. Kivimies, E. Repo-Tiihonen, H. Kautiainen, J. Tiihonen
Year: 2018
Abstract:

BACKGROUND: Substance use disorders are associated with poorer clinical outcomes in patients with schizophrenia. There is no specific treatment for amphetamine or cannabis use disorder, but methadone and buprenorphine are used as replacement therapy in the treatment of opioid dependence. Our aim was to study whether patients with schizophrenia have received opioid replacement therapy for their opioid use disorder. METHODS: The study sample consisted of 148 individuals diagnosed with schizophrenia who were in involuntary psychiatric treatment as forensic patients in Finland in 2012. The proportion of the study sample with comorbid opioid use disorder having received opioid replacement therapy prior to their forensic psychiatric treatment was compared to the available information of opioid dependent patients in general. The data were collected from forensic examination statements, patient files and other medical registers retrospectively. RESULTS: Of the study sample, 15.6% (23/148) had a history of opioid use disorder, of whom 8.7% (2/23) had received opioid replacement treatment (95% confidence interval (Cl): 1.1-28.0), even though opioid use disorder had been diagnosed in the treatment system. According the available information the corresponding proportion among patients with opioid use disorder and using substance use disorder services was 30.4% (565/1860, 95% Cl: 28.3-32.5). The fraction of patients receiving opioid replacement therapy was significantly lower among patients with schizophrenia (p = 0.022). CONCLUSIONS: Opioid replacement therapy was seldom used among schizophrenia patients who were later ordered to involuntary forensic psychiatric treatment. More attention should be paid to the possible use of opioids when planning treatment for patients with schizophrenia. TRIAL REGISTRATION: Our study is not a randomized controlled trial (but a register-based study); thus the trial registration is not applicable.

Topic(s):
Healthcare Disparities See topic collection
,
Opioids & Substance Use See topic collection
2387
Comorbid post-traumatic stress disorder and opioid dependence
Type: Journal Article
Authors: Rikinkumar S. Patel, Ahmed Elmaadawi, Suhayl Nasr, John Haskin
Year: 2017
Topic(s):
Healthcare Disparities See topic collection
,
Opioids & Substance Use See topic collection
2389
Comorbidity of chronic somatic diseases in patients with psychotic disorders and their influence on 4-year outcomes of integrated care treatment (ACCESS II study)
Type: Journal Article
Authors: M. Lambert, F. Ruppelt, A. K. Siem, A. C. Rohenkohl, V. Kraft, D. Luedecke, M. Sengutta, R. Schroter, A. Daubmann, C. U. Correll, J. Gallinat, A. Karow, K. Wiedemann, D. Schottle
Year: 2018
Publication Place: Netherlands
Topic(s):
Healthcare Disparities See topic collection
2390
Comorbidity of Lifetime History of Abuse and Trauma With Opioid Use Disorder: Implications for Nursing Assessment and Care
Type: Journal Article
Authors: Driscoll Powers, P. F. Cook, M. Weber, A. Techau, T. Sorrell
Year: 2022
Publication Place: United States
Abstract:

BACKGROUND: Opioid use disorder (OUD) is a public health crisis and is challenging to treat. Previous research has shown correlations between OUD, abuse/trauma, and chronic pain. AIMS: The purpose of this study was to investigate history of lifetime sexual, physical, and/or emotional abuse among participants in a medication-assisted treatment (MAT) program for OUD, and to investigate associations between abuse history and chronic pain. METHODS: This is a secondary analysis of intake data from a 2-year, nonexperimental cohort treatment program of patients with OUD in rural Colorado. De-identified data were provided by 476 adult MAT patients using the Adult Addiction Severity Index (ASI-6). The ASI-6 includes three yes/no questions about history of abuse (emotional, physical, and sexual), with separate scoring for "past 30 days" and "lifetime" abuse. RESULTS: Lifetime history among MAT program for OUD patients was 23% for sexual abuse, 43% for physical abuse, and 58% for emotional abuse. History of physical abuse was significantly associated with having a chronic pain diagnosis, χ(2) = 4.49, p = .03, and also with higher reported pain levels, t(460) = 2.71, p = .007. CONCLUSION: Lifetime history of physical abuse was associated with OUD and chronic pain, yet standard pain assessments do not assess these factors. In health care settings, the implementation of standardized trauma-informed screening tools, prompt recognition of abuse/trauma history, and adjunct psychological interventions may reduce stigma, reduce opioid use escalation, and help patients overcome OUD.

Topic(s):
Education & Workforce See topic collection
,
Healthcare Disparities See topic collection
,
Measures See topic collection
,
Opioids & Substance Use See topic collection
2391
Comorbidity profile and healthcare utilization in elderly patients with serious mental illnesses
Type: Journal Article
Authors: H. C. Hendrie, D. Lindgren, D. P. Hay, K. A. Lane, S. Gao, C. Purnell, S. Munger, F. Smith, J. Dickens, M. A. Boustani, C. M. Callahan
Year: 2013
Publication Place: England
Topic(s):
Healthcare Disparities See topic collection
2392
Comorbidity: Substance Use Disorders and Other Mental Illnesses
Type: Government Report
Authors: National Institute on Drug Abuse
Year: 2018
Topic(s):
Grey Literature See topic collection
,
Opioids & Substance Use See topic collection
Disclaimer:

This grey literature reference is included in the Academy's Literature Collection in keeping with our mission to gather all sources of information on integration. Grey literature is comprised of materials that are not made available through traditional publishing avenues. Often, the information from unpublished resources can be limited and the risk of bias cannot be determined.

2393
Companion to primary care mental health
Type: Book
Authors: Gabriel Ivbijaro
Year: 2012
Publication Place: London
Topic(s):
Grey Literature See topic collection
Disclaimer:

This grey literature reference is included in the Academy's Literature Collection in keeping with our mission to gather all sources of information on integration. Grey literature is comprised of materials that are not made available through traditional publishing avenues. Often, the information from unpublished resources can be limited and the risk of bias cannot be determined.

2394
Comparable analgesic efficacy of transdermal buprenorphine in patients over and under 65 years of age.
Type: Journal Article
Authors: Rudolf Likar, Eva-Maria Vadlau, Christian Breschan, Ingo Kager, Maria Korak-Leiter, Gerda Ziervogel
Year: 2008
Topic(s):
Opioids & Substance Use See topic collection
,
Healthcare Disparities See topic collection
2395
Comparative case studies in integrated care implementation from across the globe: a quest for action
Type: Journal Article
Authors: N. A. Stadnick, E. Sadler, J. Sandall, C. F. Turienzo, I. M. Bennett, J. Borkan, B. Oladeji, O. Gureje, G. A. Aarons, M. Sklar
Year: 2019
Publication Place: England
Abstract:

BACKGROUND: Integrated care is the coordination of general and behavioral health and is a highly promising and practical approach to improving healthcare delivery and patient outcomes. While there is growing interest and investment in integrated care implementation internationally, there are no formal guidelines for integrated care implementation applicable to diverse healthcare systems. Furthermore, there is a complex interplay of factors at multiple levels of influence that are necessary for successful implementation of integrated care in health systems. METHODS: Guided by the Exploration, Preparation, Implementation, Sustainment (EPIS) framework (Aarons et al., 2011), a multiple case study design was used to address two research objectives: 1) To highlight current integrated care implementation efforts through seven international case studies that target a range of healthcare systems, patient populations and implementation strategies and outcomes, and 2) To synthesize the shared and unique challenges and successes across studies using the EPIS framework. RESULTS: The seven reported case studies represent integrated care implementation efforts from five countries and continents (United States, United Kingdom, Vietnam, Israel, and Nigeria), target a range of clinical populations and care settings, and span all phases of the EPIS framework. Qualitative synthesis of these case studies illuminated common outer context, inner context, bridging and innovation factors that were key drivers of implementation. CONCLUSIONS: We propose an agenda that outlines priority goals and related strategies to advance integrated care implementation research. These goals relate to: 1) the role of funding at multiple levels of implementation, 2) meaningful collaboration with stakeholders across phases of implementation and 3) clear communication to stakeholders about integrated care implementation. TRIAL REGISTRATION: Not applicable.

Topic(s):
Education & Workforce See topic collection
2397
Comparative effectiveness of collaborative chronic care models for mental health conditions across primary, specialty, and behavioral health care settings: systematic review and meta-analysis
Type: Journal Article
Authors: E. Woltmann, A. Grogan-Kaylor, B. Perron, H. Georges, A. M. Kilbourne, M. S. Bauer
Year: 2012
Publication Place: United States
Abstract: OBJECTIVE: Collaborative chronic care models (CCMs) improve outcome in chronic medical illnesses and depression treated in primary care settings. The effect of such models across other treatment settings and mental health conditions has not been comprehensively assessed. The authors performed a systematic review and meta-analysis to assess the comparative effectiveness of CCMs for mental health conditions across disorders and treatment settings. METHOD: Randomized controlled trials comparing CCMs with other care conditions, published or in press by August 15, 2011, were identified in a literature search and through contact with investigators. CCMs were defined a priori as interventions with at least three of the six components of the Improving Chronic Illness Care initiative (patient self-management support, clinical information systems, delivery system redesign, decision support, organizational support, and community resource linkages). Articles were included if the CCM effect on mental health symptoms or mental quality of life was reported. Data extraction included analyses of these outcomes plus social role function, physical and overall quality of life, and costs. Meta-analyses included comparisons using unadjusted continuous measures. RESULTS: Seventy-eight articles yielded 161 analyses from 57 trials (depression, N=40; bipolar disorder, N=4; anxiety disorders, N=3; multiple/other disorders, N=10). The meta-analysis indicated significant effects across disorders and care settings for depression as well as for mental and physical quality of life and social role function (Cohen's d values, 0.20-0.33). Total health care costs did not differ between CCMs and comparison models. A systematic review largely confirmed and extended these findings across conditions and outcome domains. CONCLUSIONS: CCMs can improve mental and physical outcomes for individuals with mental disorders across a wide variety of care settings, and they provide a robust clinical and policy framework for care integration.
Topic(s):
Healthcare Policy See topic collection
2398
Comparative effectiveness of extended-release naltrexone versus buprenorphine-naloxone for opioid relapse prevention (X:BOT): a multicentre, open-label, randomised controlled trial
Type: Journal Article
Authors: Joshua D. Lee, Edward V. Nunes, Patricia Novo, Ken Bachrach, Genie L. Bailey, Snehal Bhatt, Sarah Farkas, Marc Fishman, Phoebe Gauthier, Candace C. Hodgkins, Jacquie King, Robert Lindblad, David Liu, Abigail G. Matthews, Abigail G. Matthews, Jeanine May, Michelle Peavy, Stephen Ross, Dagmar Salazar, Paul Schkolnik, Dikla Shmueli-Blumberg, Don Stablein, Geetha Subramaniam, John Rotrosen
Year: 2018
Abstract: Background: Extended-release naltrexone (XR-NTX), an opioid antagonist, and sublingual buprenorphine-naloxone (BUP-NX), a partial opioid agonist, are pharmacologically and conceptually distinct interventions to prevent opioid relapse. We aimed to estimate the difference in opioid relapse-free survival between XR-NTX and BUP-NX. Methods: We initiated this 24 week, open-label, randomised controlled, comparative effectiveness trial at eight US community-based inpatient services and followed up participants as outpatients. Participants were 18 years or older, had Diagnostic and Statistical Manual of Mental Disorders-5 opioid use disorder, and had used non-prescribed opioids in the past 30 days. We stratified participants by treatment site and opioid use severity and used a web-based permuted block design with random equally weighted block sizes of four and six for randomisation (1:1) to receive XR-NTX or BUP-NX. XR-NTX was monthly intramuscular injections (Vivitrol; Alkermes) and BUP-NX was daily self-administered buprenorphine-naloxone sublingual film (Suboxone; Indivior). The primary outcome was opioid relapse-free survival during 24 weeks of outpatient treatment. Relapse was 4 consecutive weeks of any non-study opioid use by urine toxicology or self-report, or 7 consecutive days of self-reported use. This trial is registered with ClinicalTrials.gov, NCT02032433. Findings: Between Jan 30, 2014, and May 25, 2016, we randomly assigned 570 participants to receive XR-NTX (n=283) or BUP-NX (n=287). The last follow-up visit was Jan 31, 2017. As expected, XR-NTX had a substantial induction hurdle: fewer participants successfully initiated XR-NTX (204 [72%] of 283) than BUP-NX (270 [94%] of 287; p<0·0001). Among all participants who were randomly assigned (intention-to-treat population, n=570) 24 week relapse events were greater for XR-NTX (185 [65%] of 283) than for BUP-NX (163 [57%] of 287; hazard ratio [HR] 1·36, 95% CI 1·10–1·68), most or all of this difference accounted for by early relapse in nearly all (70 [89%] of 79) XR-NTX induction failures. Among participants successfully inducted (per-protocol population, n=474), 24 week relapse events were similar across study groups (p=0·44). Opioid-negative urine samples (p<0·0001) and opioid-abstinent days (p<0·0001) favoured BUP-NX compared with XR-NTX among the intention-to-treat population, but were similar across study groups among the per-protocol population. Self-reported opioid craving was initially less with XR-NTX than with BUP-NX (p=0·0012), then converged by week 24 (p=0·20). With the exception of mild-to-moderate XR-NTX injection site reactions, treatment-emergent adverse events including overdose did not differ between treatment groups. Five fatal overdoses occurred (two in the XR-NTX group and three in the BUP-NX group). Interpretation: In this population it is more difficult to initiate patients to XR-NTX than BUP-NX, and this negatively affected overall relapse. However, once initiated, both medications were equally safe and effective. Future work should focus on facilitating induction to XR-NTX and on improving treatment retention for both medications.
Topic(s):
Opioids & Substance Use See topic collection
2399
Comparative Effectiveness of Standard versus Patient-Centered Collaborative Care Interventions for Depression among African Americans in Primary Care Settings: The BRIDGE Study
Type: Journal Article
Authors: Lisa A. Cooper, Bri K. Ghods Dinoso, Daniel E. Ford, Debra L. Roter, Annelle B. Primm, Susan M. Larson, James M. Gill, Gary J. Noronha, Elias K. Shaya, Nae-Yuh Wang
Year: 2013
Publication Place: United Kingdom
Topic(s):
Healthcare Disparities See topic collection
2400
Comparative efficacy and acceptability of psychosocial interventions for individuals with cocaine and amphetamine addiction: A systematic review and network meta-analysis
Type: Journal Article
Authors: F. De Crescenzo, M. Ciabattini, G. L. D'Alò, R. De Giorgi, C. Del Giovane, C. Cassar, L. Janiri, N. Clark, M. J. Ostacher, A. Cipriani
Year: 2018
Abstract: BACKGROUND: Clinical guidelines recommend psychosocial interventions for cocaine and/or amphetamine addiction as first-line treatment, but it is still unclear which intervention, if any, should be offered first. We aimed to estimate the comparative effectiveness of all available psychosocial interventions (alone or in combination) for the short- and long-term treatment of people with cocaine and/or amphetamine addiction. METHODS AND FINDINGS: We searched published and unpublished randomised controlled trials (RCTs) comparing any structured psychosocial intervention against an active control or treatment as usual (TAU) for the treatment of cocaine and/or amphetamine addiction in adults. Primary outcome measures were efficacy (proportion of patients in abstinence, assessed by urinalysis) and acceptability (proportion of patients who dropped out due to any cause) at the end of treatment, but we also measured the acute (12 weeks) and long-term (longest duration of study follow-up) effects of the interventions and the longest duration of abstinence. Odds ratios (ORs) and standardised mean differences were estimated using pairwise and network meta-analysis with random effects. The risk of bias of the included studies was assessed with the Cochrane tool, and the strength of evidence with the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. We followed the PRISMA for Network Meta-Analyses (PRISMA-NMA) guidelines, and the protocol was registered in PROSPERO (CRD 42017042900). We included 50 RCTs evaluating 12 psychosocial interventions or TAU in 6,942 participants. The strength of evidence ranged from high to very low. Compared to TAU, contingency management (CM) plus community reinforcement approach was the only intervention that increased the number of abstinent patients at the end of treatment (OR 2.84, 95% CI 1.24-6.51, P = 0.013), and also at 12 weeks (OR 7.60, 95% CI 2.03-28.37, P = 0.002) and at longest follow-up (OR 3.08, 95% CI 1.33-7.17, P = 0.008). At the end of treatment, CM plus community reinforcement approach had the highest number of statistically significant results in head-to-head comparisons, being more efficacious than cognitive behavioural therapy (CBT) (OR 2.44, 95% CI 1.02-5.88, P = 0.045), non-contingent rewards (OR 3.31, 95% CI 1.32-8.28, P = 0.010), and 12-step programme plus non-contingent rewards (OR 4.07, 95% CI 1.13-14.69, P = 0.031). CM plus community reinforcement approach was also associated with fewer dropouts than TAU, both at 12 weeks and the end of treatment (OR 3.92, P < 0.001, and 3.63, P < 0.001, respectively). At the longest follow-up, community reinforcement approach was more effective than non-contingent rewards, supportive-expressive psychodynamic therapy, TAU, and 12-step programme (OR ranging between 2.71, P = 0.026, and 4.58, P = 0.001), but the combination of community reinforcement approach with CM was superior also to CBT alone, CM alone, CM plus CBT, and 12-step programme plus non-contingent rewards (ORs between 2.50, P = 0.039, and 5.22, P < 0.001). The main limitations of our study were the quality of included studies and the lack of blinding, which may have increased the risk of performance bias. However, our analyses were based on objective outcomes, which are less likely to be biased. CONCLUSIONS: To our knowledge, this network meta-analysis is the most comprehensive synthesis of data for psychosocial interventions in individuals with cocaine and/or amphetamine addiction. Our findings provide the best evidence base currently available to guide decision-making about psychosocial interventions for individuals with cocaine and/or amphetamine addiction and should inform patients, clinicians, and policy-makers.
Topic(s):
Opioids & Substance Use See topic collection