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Opioids & SU

The Literature Collection contains over 11,000 references for published and grey literature on the integration of behavioral health and primary care. Learn More

Use the Search feature below to find references for your terms across the entire Literature Collection, or limit your searches by Authors, Keywords, or Titles and by Year, Type, or Topic. View your search results as displayed, or use the options to: Show more references per page; Sort references by Title or Date; and Refine your search criteria. Expand an individual reference to View Details. Full-text access to the literature may be available through a link to PubMed, a DOI, or a URL. References may also be exported for use in bibliographic software (e.g., EndNote, RefWorks, Zotero).

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12255 Results
2301
Clinic-wide depression screening in the waiting room using electronic health record integrated patient health questionnaire surveys: Implementation science outcomes for reach, inequitable reach and perceptions of barriers
Type: Journal Article
Authors: A. M. Stover, S. Pathak, C. M. Belden, R. Kurtzman, C. Ikemeh, C. Canter, A. B. Smith, A. E. Chung
Year: 2025
Topic(s):
HIT & Telehealth See topic collection
,
Healthcare Disparities See topic collection
2303
Clinical and cost effectiveness of mobile phone supported self monitoring of asthma: multicentre randomised controlled trial
Type: Journal Article
Authors: D. Ryan, D. Price, S. D. Musgrave, S. Malhotra, A. J. Lee, D. Ayansina, A. Sheikh, L. Tarassenko, C. Pagliari, H. Pinnock
Year: 2012
Publication Place: England
Abstract: OBJECTIVE: To determine whether mobile phone based monitoring improves asthma control compared with standard paper based monitoring strategies. DESIGN: Multicentre randomised controlled trial with cost effectiveness analysis. SETTING: UK primary care. PARTICIPANTS: 288 adolescents and adults with poorly controlled asthma (asthma control questionnaire (ACQ) score >/= 1.5) from 32 practices. INTERVENTION: Participants were centrally randomised to twice daily recording and mobile phone based transmission of symptoms, drug use, and peak flow with immediate feedback prompting action according to an agreed plan or paper based monitoring. MAIN OUTCOME MEASURES: Changes in scores on asthma control questionnaire and self efficacy (knowledge, attitude, and self efficacy asthma questionnaire (KASE-AQ)) at six months after randomisation. Assessment of outcomes was blinded. Analysis was on an intention to treat basis. RESULTS: There was no significant difference in the change in asthma control or self efficacy between the two groups (ACQ: mean change 0.75 in mobile group v 0.73 in paper group, mean difference in change -0.02 (95% confidence interval -0.23 to 0.19); KASE-AQ score: mean change -4.4 v -2.4, mean difference 2.0 (-0.3 to 4.2)). The numbers of patients who had acute exacerbations, steroid courses, and unscheduled consultations were similar in both groups, with similar healthcare costs. Overall, the mobile phone service was more expensive because of the expenses of telemonitoring. CONCLUSIONS: Mobile technology does not improve asthma control or increase self efficacy compared with paper based monitoring when both groups received clinical care to guidelines standards. The mobile technology was not cost effective. TRIAL REGISTRATION: Clinical Trials NCT00512837.
Topic(s):
HIT & Telehealth See topic collection
2304
Clinical care quality among veterans health administration patients with mental illness following medical home implementation
Type: Journal Article
Authors: Kendall C. Browne, Katherine D. Hoerster, Rebecca Piegari, John C. Fortney, Karin N. Nelson, Edward P. Post, Stephan D. Fihn, Alaina M. Mori, Ranak B. Trivedi
Year: 2019
Topic(s):
Healthcare Disparities See topic collection
,
Medical Home See topic collection
,
Opioids & Substance Use See topic collection
2305
Clinical case conference: Unobserved "home" induction onto buprenorphine.
Type: Journal Article
Authors: Joshua D. Lee, Jennifer McNeely, Ellie Grossman, Frank Vocci, David A. Fiellin
Year: 2014
Topic(s):
Opioids & Substance Use See topic collection
2306
Clinical challenges in managing buprenorphine diversion
Type: Journal Article
Authors: Michelle R. Lofwall, Sharon L. Walsh
Year: 2010
Topic(s):
Opioids & Substance Use See topic collection
,
Education & Workforce See topic collection
2307
Clinical community health workers: linchpin of the medical home
Type: Journal Article
Authors: K. Volkmann, T. Castanares
Year: 2011
Publication Place: United States
Abstract: The emerging clinical community health worker model integrates community health workers as integral members of primary care teams inside a medical home. This evaluation documents the case management services provided by 2 clinical community health worker programs at La Clinica del Carino in Hood River, Oregon, and how they affected the care team's ability to deliver efficient, effective primary care. Clinical community health workers have the potential to make a significant impact on clinical efficiency and effectiveness as ambulatory primary care clinics strive to transform into high-quality, patient-centered medical homes and become linchpins in accountable care organizations.
Topic(s):
Education & Workforce See topic collection
,
Medical Home See topic collection
2308
Clinical computing: electronic sign-out using a personal digital assistant
Type: Journal Article
Authors: J. Luo, R. Hales, D. Hilty, C. Brennan
Year: 2001
Publication Place: United States
Topic(s):
HIT & Telehealth See topic collection
2310
Clinical coordination in accountable care organizations: A qualitative study
Type: Journal Article
Authors: Valerie A. Lewis, Karen Schoenherr, Taressa Fraze, Aleen Cunningham
Year: 2019
Publication Place: United States
Abstract:

BACKGROUND: Accountable care organizations (ACOs) are becoming a common payment and delivery model. Despite widespread interest, little empirical research has examined what efforts or strategies ACOs are using to change care and reduce costs. Knowledge of ACOs' clinical efforts can provide important context for understanding ACO performance, particularly to distinguish arenas where ACOs have and have not attempted care transformation. PURPOSE: The aim of the study was to understand ACOs' efforts to change clinical care during the first 18 months of ACO contracts. METHODS: We conducted semistructured interviews between July and December 2013. Our sample includes ACOs that began performance contracts in 2012, including Medicare Shared Savings Program and Pioneer participants, stratified across key factors. In total, we conducted interviews with executives from 30 ACOs. Iterative qualitative analysis identified common patterns and themes. RESULTS: ACOs in the first year of performance contracts are commonly focusing on four areas: first, transforming primary care through increased access and team-based care; second, reducing avoidable emergency department use; third, strengthening practice-based care management; and fourth, developing new boundary spanner roles and activities. ACOs were doing little around transforming specialty care, acute and postacute care, or standardizing care across practices during the first 18 months of ACO performance contracts. PRACTICE IMPLICATIONS: Results suggest that cost reductions associated with ACOs in the first years of contracts may be related to primary care. Although in the long term many hope ACOs will achieve coordination across a wide array of care settings and providers, in the short term providers under ACO contracts are focused largely on primary care-related strategies. Our work provides a template of the common areas of clinical activity in the first years of ACO contracts, which may be informative to providers considering becoming an ACO. Further research will be needed to understand how these strategies are associated with performance.

Topic(s):
Education & Workforce See topic collection
,
Financing & Sustainability See topic collection
2311
Clinical correlates of health-related quality of life among opioid-dependent patients
Type: Journal Article
Authors: K. C. Heslin, J. A. Stein, K. G. Heinzerling, D. Pan, C. Magladry, R. D. Hays
Year: 2011
Publication Place: Netherlands
Abstract: PURPOSE: Previous work suggests that opioid users have lower health-related quality of life (HRQOL) than patients with more prevalent chronic illnesses such as hypertension or diabetes. Although comparisons with population norms are informative, studies of the correlates of HRQOL for opioid users are needed to plan clinical services. METHODS: We tested a conceptual model of the pathways between physiologic factors and symptoms in relation to HRQOL among 344 opioid users in a clinical trial. Physical and mental HRQOL were measured by the Short-Form (SF)-36; withdrawal signs, symptoms, and functioning were also measured with validated instruments. Using structural equation modeling, we tested hypotheses that medical history directly predicts withdrawal signs and symptoms, and that medical history, withdrawal signs and symptoms, and functioning predict the physical and mental HRQOL latent variables of the SF-36. RESULTS: Most hypothesized relationships were significant, and model fit was good. The model explained 36% of the variance in mental HRQOL and 34% of the variance in physical HRQOL. CONCLUSIONS: The conceptual framework appears valid for explaining variation in the physical and mental HRQOL of opioid users undergoing medically managed withdrawal. Analysis of longitudinal data would help to evaluate more rigorously the adequacy of the model for explaining HRQOL in opioid withdrawal.
Topic(s):
Opioids & Substance Use See topic collection
2312
Clinical cues for detection of people with undiscovered depression in primary health care: A case-control study.
Type: Journal Article
Authors: Lena Flyckt, Ejda Hassler, Louise Lotfi, Ingvar Krakau, Gunnar H. Nilsson
Year: 2014
Topic(s):
General Literature See topic collection
2313
Clinical decision support as an implementation strategy to expand identification and administration of treatment of opioid use disorder in the emergency department
Type: Journal Article
Authors: J. A. Lebin, S. Sommers, Z. Lun, C. Hensen, J. A. Hoppe
Year: 2025
Abstract:

INTRODUCTION: US opioid overdoses and deaths continue to increase, despite historic national investment to mitigate risk and improve access to evidence-based treatment. Unfortunately, implementation of emergency department (ED) buprenorphine - an effective medical treatment for opioid use disorder (OUD) - has been limited. Our objective was to assess the effectiveness of an electronic health record (EHR)-integrated, interruptive clinical decision support (CDS) tool to improve rates of ED initiated OUD treatment. METHODS: This is an observational, pre-post study of a CDS tool designed to identify and facilitate treatment of patients with OUD using electronic health record data. Patients were included if treated at our urban, academic ED between May 1, 2022, and November 8, 2023. The CDS triggered based on a rules-based algorithm using routinely collected EHR data which were identified from a previously validated EHR OUD phenotype. Outcomes are organized under a modified RE-AIM framework, with the primary outcome, Effectiveness, measured by the proportion of OUD patients receiving buprenorphine (administered/prescribed; filled prescriptions). Secondary outcomes include patient Reach, clinician Adoption, and fidelity to Implementation. Chi Square tests and Bayesian structural time-series models evaluate differences in outcomes before and after CDS implementation (CausalImpact package v1.3.0 in R v4.4.0). RESULTS: There were 171,221 total ED visits during the study period. Patient characteristics before and after CDS implementation were similar. CDS triggered in 4.7 % (2754/58,173) of encounters after initiation of intervention, reaching 116 unique emergency medicine providers and 2566 ED patients. Clinicians adopted the CDS, accessing the OUD treatment pathway link or ordering a social work consult for substance use, in 27 % (1266/4746) of CDS alerts. When compared to the pre-implementation period, CDS implementation was associated with increased buprenorphine administration in the ED by 31 % (95 % CI: 16-47 %, p = 0.001), buprenorphine prescribing from the ED by 20 % (95 % CI: 5-38 %, p = 0.007), and the buprenorphine fill rate at an affiliated ED pharmacy by 17 % (95 % CI: 1-36 %, p = 0.017). CONCLUSIONS: Implementation of an EHR-integrated, CDS was associated with increased ED buprenorphine administration, prescribing, and prescription fills among ED patients with OUD. Further efforts are needed to assess maintenance strategies that improve adoption, minimize interruptiveness, and optimize workflow congruence.

Topic(s):
Opioids & Substance Use See topic collection
,
HIT & Telehealth See topic collection
2314
Clinical decision support system in dementia care
Type: Journal Article
Authors: H. Lindgren, P. Eklund, S. Eriksson
Year: 2002
Publication Place: Netherlands
Abstract: In this paper we present a prototype system as a tool for clinical decision support in the domain of cognitive diseases. The number of patients is increasing while the number of patients that the general practitioner (GP) meets in primary care still is too low to make the GP well trained in diagnostics and management of patients in the area of cognitive diseases. In addition, new treatment strategies are established in clinical routine directed towards cognitive deficiencies with behavioural and psychological symptoms in the presence of dementia (BPSD).
Topic(s):
Education & Workforce See topic collection
,
HIT & Telehealth See topic collection
2315
Clinical differences between opioid abuse classes ameliorated after 1 year of buprenorphine-medication assisted treatment
Type: Journal Article
Authors: J. Tkacz, J. Severt, C. Kassed, C. Ruetsch
Year: 2012
Publication Place: England
Abstract: This study compared the clinical and demographic profiles of three opioid-dependent user groups, and measured their response to 1 year of buprenorphine-medication assisted treatment. Opioid prescription, street, and combination (street + prescription) users completed the Addiction Severity Index multiple times over the course of one treatment year. Although groups differed on all measured demographics (P values <.05) and on six of seven Addiction Severity Index composite scores at induction (P values <.05), differences were ameliorated after 1 year. Findings highlight the disparities between the various opioid-dependent patient subpopulations and suggest that buprenorphine-medication assisted treatment is an effective treatment across user subtypes.
Topic(s):
Opioids & Substance Use See topic collection
2316
Clinical Drug Testing in Primary Care.Technical Assistance Publication Series (TAP) 32
Type: Government Report
Authors: Substance Abuse and Mental Health Services Administration
Year: 2012
Publication Place: Rockville, MD
Topic(s):
Key & Foundational See topic collection
,
Grey Literature See topic collection
Disclaimer:

This grey literature reference is included in the Academy's Literature Collection in keeping with our mission to gather all sources of information on integration. Grey literature is comprised of materials that are not made available through traditional publishing avenues. Often, the information from unpublished resources can be limited and the risk of bias cannot be determined.

2318
Clinical effectiveness and cost-effectiveness of collaborative care for depression in UK primary care (CADET): a cluster randomised controlled trial
Type: Journal Article
Authors: D. A. Richards, P. Bower, C. Chew-Graham, L. Gask, K. Lovell, J. Cape, S. Pilling, R. Araya, D. Kessler, M. Barkham, J. M. Bland, S. Gilbody, C. Green, G. Lewis, C. Manning, E. Kontopantelis, J. J. Hill, A. Hughes-Morley, A. Russell
Year: 2016
Publication Place: England
Abstract: BACKGROUND: Collaborative care is effective for depression management in the USA. There is little UK evidence on its clinical effectiveness and cost-effectiveness. OBJECTIVE: To determine the clinical effectiveness and cost-effectiveness of collaborative care compared with usual care in the management of patients with moderate to severe depression. DESIGN: Cluster randomised controlled trial. SETTING: UK primary care practices (n = 51) in three UK primary care districts. PARTICIPANTS: A total of 581 adults aged >/= 18 years in general practice with a current International Classification of Diseases, Tenth Edition depressive episode, excluding acutely suicidal people, those with psychosis, bipolar disorder or low mood associated with bereavement, those whose primary presentation was substance abuse and those receiving psychological treatment. INTERVENTIONS: Collaborative care: 14 weeks of 6-12 telephone contacts by care managers; mental health specialist supervision, including depression education, medication management, behavioural activation, relapse prevention and primary care liaison. Usual care was general practitioner standard practice. MAIN OUTCOME MEASURES: Blinded researchers collected depression [Patient Health Questionnaire-9 (PHQ-9)], anxiety (General Anxiety Disorder-7) and quality of life (European Quality of Life-5 Dimensions three-level version), Short Form questionnaire-36 items) outcomes at 4, 12 and 36 months, satisfaction (Client Satisfaction Questionnaire-8) outcomes at 4 months and treatment and service use costs at 12 months. RESULTS: In total, 276 and 305 participants were randomised to collaborative care and usual care respectively. Collaborative care participants had a mean depression score that was 1.33 PHQ-9 points lower [n = 230; 95% confidence interval (CI) 0.35 to 2.31; p = 0.009] than that of participants in usual care at 4 months and 1.36 PHQ-9 points lower (n = 275; 95% CI 0.07 to 2.64; p = 0.04) at 12 months after adjustment for baseline depression (effect size 0.28, 95% CI 0.01 to 0.52; odds ratio for recovery 1.88, 95% CI 1.28 to 2.75; number needed to treat 6.5). Quality of mental health but not physical health was significantly better for collaborative care at 4 months but not at 12 months. There was no difference for anxiety. Participants receiving collaborative care were significantly more satisfied with treatment. Differences between groups had disappeared at 36 months. Collaborative care had a mean cost of pound272.50 per participant with similar health and social care service use between collaborative care and usual care. Collaborative care offered a mean incremental gain of 0.02 (95% CI -0.02 to 0.06) quality-adjusted life-years (QALYs) over 12 months at a mean incremental cost of pound270.72 (95% CI - pound202.98 to pound886.04) and had an estimated mean cost per QALY of pound14,248, which is below current UK willingness-to-pay thresholds. Sensitivity analyses including informal care costs indicated that collaborative care is expected to be less costly and more effective. The amount of participant behavioural activation was the only effect mediator. CONCLUSIONS: Collaborative care improves depression up to 12 months after initiation of the intervention, is preferred by patients over usual care, offers health gains at a relatively low cost, is cost-effective compared with usual care and is mediated by patient activation. Supervision was by expert clinicians and of short duration and more intensive therapy may have improved outcomes. In addition, one participant requiring inpatient treatment incurred very significant costs and substantially inflated our cost per QALY estimate. Future work should test enhanced intervention content not collaborative care per se. TRIAL REGISTRATION: Current Controlled Trials ISRCTN32829227. FUNDING: This project was funded by the Medical Research Council (MRC) (G0701013) and managed by the National Institute for Health Research (NIHR) on behalf of the MRC-NIHR partnership.
Topic(s):
Education & Workforce See topic collection
,
Financing & Sustainability See topic collection
2319
Clinical effects of unintentional pediatric buprenorphine exposures: experience at a single tertiary care center
Type: Journal Article
Authors: Michael S. Toce, Michele M. Burns, Katherine A. O'Donnell
Year: 2017
Publication Place: England
Abstract:

CONTEXT: Exploratory buprenorphine ingestions in young children have been associated with clinically significant toxicity. However, detailed data on the clinical presentation and management of these patients are lacking. In an attempt to obtain more comprehensive data, we sought to examine a single center cohort of patients with report of buprenorphine exposure and provide descriptive analysis of rates of respiratory depression, time to respiratory depression, interventions, disposition, and outcomes. STUDY DESIGN: We performed a retrospective cohort study at a single pediatric tertiary care center of children between the age of 6 months and 7 years of age hospitalized between 1 January 2006 and 1 September 2014 with report of buprenorphine or buprenorphine/naloxone exposure. Patients with possible exposure to more than one agent were excluded. We extracted clinical findings, including time to respiratory depression, interventions, and disposition from the medical record. RESULTS: Eighty-eight patients met the inclusion criteria. Seven patients were excluded. The median age was 24 months [IQR 18-30]. 20 patients (23%) received activated charcoal while 48 (55%) were treated with naloxone. 36 (41%) patients were admitted to the ICU. Observed clinical effects included respiratory depression (83%), oxygen saturation by pulse oximetry (SpO2) < 93% (28%), depressed mental status (80%), miosis (77%), and emesis (45%). Median time from exposure to respiratory depression was 263 min [IQR 105-486]. The median hospital length of stay was 22 h [IQR 20-26] and was positively associated with estimated exposure dose (p = 0.002). CONCLUSION: Pediatric patients exposed to buprenorphine are likely to exhibit signs and symptoms of opioid toxicity, including respiratory depression, altered mental status and miosis. Although the majority of patients developed signs of clinical toxicity within 8 h of reported exposure, the optimum duration of monitoring remains unclear.

Topic(s):
Healthcare Disparities See topic collection
,
Opioids & Substance Use See topic collection
2320
Clinical efficacy of computerised cognitive-behavioural therapy for anxiety and depression in primary care: randomised controlled trial
Type: Journal Article
Authors: Brian Everitt, David Goldberg, Jeffrey A. Gray, Anthony Mann, Isaac Marks, Judith Proudfoot, Clash Ryden, David A. Shapiro, Andre Tylee
Year: 2004
Abstract: Background: Preliminary results have demonstrated the clinical efficacy of computerised cognitive-behavioural therapy (CBT) in the treatment of anxiety and depression in primary care. Aims: To determine, in an expanded sample, the dependence of the efficacy of this therapy upon clinical and demographic variables. Method: A sample of 274 patients with anxiety and/or depression were randomly allocated to receive, with or without medication, computerised CBT or treatment as usual, with follow-up assessment at 6 months. Results: The computerised therapy improved depression, negative attributional style, work and social adjustment, without interaction with drug treatment, duration of preexisting illness or severity of existing illness. For anxiety and positive attributional style, treatment interacted with severity such that computerised therapy did better than usual treatment for more disturbed patients. Computerised therapy also led to greater satisfaction with treatment. Conclusions: Computer-delivered CBT is a widely applicable treatment for anxiety and/or depression in general practice. Declaration of interest: J.P. and J.A.G. are minority partners in the commercial exploitation of Beating the Blues, and D.G. and D.A.S. are occasional consultants to Ultrasis plc. (Original abstract)
Topic(s):
HIT & Telehealth See topic collection