Polysubstance Use

This guide provides considerations and strategies for clinicians and organizations implementing evidence-based practices. Approaches presented will assist clinicians, behavioral health organizations, primary care providers, insurers, and policy makers in understanding, selecting, and implementing evidence-based interventions that support adults with concurrent substance use and/or concurrent substance use disorders, including alcohol.

A comprehensive household interview survey of substance use, substance use disorders, mental health, and the receipt of treatment services for these disorders in the United States.

A fact sheet outlining the definition and effects of Polydrug use.

This brief describes research documenting the added challenges stimulant use contributes to those who use opioids and patient-centered approaches for working with people who use stimulants that are enrolled in medication treatment for opioid use disorder.

This brief reviews opioid and stimulant trends in availability, use, and impacts; compares opioids and stimulants in terms of drug effects and motivations for use; and examines the factors that drive co-use.

This guide describes relevant research findings, examines best practices, identifies knowledge gaps and implementation challenges, and offers useful resources for treating stimulant use disorders.