Literature Collection

6321

Naloxone's role in the national opioid crisis-past struggles, current efforts, and future opportunities

Type: Journal Article

Authors: A. S. Bennett, L. Elliott

Year: 2021

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6322

Naltrexone (50 mg) Plus Psychotherapy in Alcohol-Dependent Patients: A Meta-Analysis of Randomized Controlled Trials

Type: Journal Article

Authors: Joanna Jarosz, Katarzyna Miernik, Maria Wachal, Jacek Walczak, Gunther Krumpl

Year: 2013

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6323

Naltrexone alters responses to social and physical warmth: Implications for social bonding

Type: Journal Article

Authors: Tristen K. Inagaki, Laura I. Hazlett, Carmen Andreescu

Year: 2019

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6324

Naltrexone at low doses upregulates a unique gene expression not seen with normal doses: Implications for its use in cancer therapy

Type: Journal Article

Authors: W. M. Liu, K. A. Scott, J. L. Dennis, E. Kaminska, A. J. Levett, A. G. Dalgleish

Year: 2016

Publication Place: Greece

Abstract: It has been reported that lower doses of the opioid antagonist naltrexone are able to reduce tumour growth by interfering with cell signalling as well as by modifying the immune system. We have evaluated the gene expression profile of a cancer cell line after treatment with low-dose naltrexone (LDN), and assessed the effect that adapting treatment schedules with LDN may have on enhancing efficacy. LDN had a selective impact on genes involved with cell cycle regulation and immune modulation. Similarly, the pro-apoptotic genes BAD and BIK1 were increased only after LDN. Continuous treatment with LDN had little effect on growth in different cell lines; however, altering the treatment schedule to include a phase of culture in the absence of drug following an initial round of LDN treatment, resulted in enhanced cell killing. Furthermore, cells pre-treated with LDN were more sensitive to the cytotoxic effects of a number of common chemotherapy agents. For example, priming HCT116 with LDN before treatment with oxaliplatin significantly increased cell killing to 49+/-7.0 vs. 14+/-2.4% in cultures where priming was not used. Interestingly, priming with NTX before oxaliplatin resulted in just 32+/-1.8% cell killing. Our data support further the idea that LDN possesses anticancer activity, which can be improved by modifying the treatment schedule.

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6325

Naltrexone Compared With Buprenorphine or Methadone in Pregnancy: A Systematic Review

Type: Journal Article

Authors: S. Atluru, A. K. Bruehlman, P. Vaughn, C. W. Schauberger, M. C. Smid

Year: 2024

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6326

Naltrexone differentially modulates the neural correlates of motor impulse control in abstinent alcohol-dependent and polysubstance-dependent individuals

Type: Journal Article

Authors: L. J. Nestor, L. M. Paterson, A. Murphy, J. McGonigle, C. Orban, L. Reed, E. Taylor, R. Flechais, D. Smith, E. T. Bullmore, K. D. Ersche, J. Suckling, R. Elliott, B. Deakin, I. Rabiner, Lingford Hughes, B. J. Sahakian, T. W. Robbins, D. J. Nutt, ICCAM Consortium

Year: 2019

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6327

Naltrexone for adolescent opioid use disorder: A bridge in the treatment gap?

Type: Journal Article

Authors: Matthew LaCasse, Joanna Quigley

Year: 2022

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6328

Naltrexone treatment for opioid dependence: does its effectiveness depend on testing the blockade?

Type: Journal Article

Authors: M. A. Sullivan, A. Bisaga, J. J. Mariani, A. Glass, F. R. Levin, S. D. Comer, E. V. Nunes

Year: 2013

Publication Place: Ireland

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6329

Naltrexone Treatment for Opioid Use Disorder: Training for Clinicians (Part 1)

Type: Web Resource

Authors: Adam Bisaga

Year: 2017

Topic(s):

, ,

Disclaimer:

This grey literature reference is included in the Academy's Literature Collection in keeping with our mission to gather all sources of information on integration. Grey literature is comprised of materials that are not made available through traditional publishing avenues. Often, the information from unpublished resources can be limited and the risk of bias cannot be determined.

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6330

Naltrexone: A Pan-Addiction Treatment?

Type: Journal Article

Authors: E. Aboujaoude, W. O. Salame

Year: 2016

Abstract: Addiction is a major public health problem with few efficacious and safe treatments. The goal of this review is to provide an evidence-based assessment of the therapeutic role of the opioid antagonist naltrexone across the addiction spectrum-substance-based and behavioral. The PubMed database was searched for randomized, placebo-controlled clinical trials that investigated the oral or intramuscular long-acting formulation of naltrexone in substance use disorders or behavioral addictions such as pathological gambling, kleptomania, and trichotillomania. Thirty-nine efficacy studies were retrieved, covering alcohol use disorder (n = 22), opioid use disorder (n = 6), nicotine use disorder (n = 5), stimulant use disorder (n = 2), gambling disorder (n = 2), trichotillomania (n = 1), and kleptomania (n = 1). Despite the very different presentations within and between both addiction categories, the data, as a whole, show consistency in favor of naltrexone's relative efficacy and safety. Given the potential benefit and good tolerability revealed in the studies, the high morbidity associated with addiction, and the dearth of alternate treatments, naltrexone would seem like an underutilized treatment option. Further, naltrexone's seemingly broad anti-addiction efficacy supports a shared role for brain opioid pathways in the pathophysiology of addiction, broadly defined. More studies investigating the efficacy and tolerability of naltrexone and other opioid modulators are warranted. Studies should also further examine the effect of combining psychotherapy with naltrexone, as well as the potential role of naltrexone in treating comorbid addictions.

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6331

NAMI: Primary care doctors critical to detecting mental illness

Type: Journal Article

Year: 2011

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6332

Narcotics Anonymous members in recovery from methamphetamine use disorder

Type: Journal Article

Authors: M. Galanter, W. L. White, B. Hunter

Year: 2023

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6333

Narrative Review of Provider Behavior in Primary Care Behavioral Health: How Process Data Can Inform Quality Improvement

Type: Journal Article

Authors: G. P. Beehler, K. R. Lilienthal, K. Possemato, E. M. Johnson, P. R. King, R. L. Shepardson, C. L. Vair, J. Reyner, J. S. Funderburk, S. A. Maisto, L. O. Wray

Year: 2017

Publication Place: United States

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6334

Narrative review: Buprenorphine for opioid-dependent patients in office practice

Type: Journal Article

Authors: L. E. Sullivan, D. A. Fiellin

Year: 2008

Publication Place: United States

Abstract: The profile of opioid dependence in the United States is changing. Abuse of prescription opioids is more common than that of illicit opioids: Recent data indicate that approximately 1.6 million persons abuse or are dependent on prescription opioids, whereas 323,000 abuse or are dependent on heroin. Despite this prevalence, nearly 80% of opioid-dependent persons remain untreated. One option for expanding treatment is the use of buprenorphine and the buprenorphine-naloxone combination. Buprenorphine is a partial opioid agonist that can be prescribed by trained physicians and dispensed at pharmacies. This article addresses the clinical presentation of a patient with opioid dependence and describes the relatively new practice of office-based treatment with buprenorphine-naloxone. The different components of treatment; the role of the physician who provides this treatment; and the logistics of treating this growing, multifaceted patient population are also examined.

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6335

Narrative-informed medical family therapy: Using narrative therapy practices in brief medical encounters.

Type: Journal Article

Authors: Jacqueline Williams-Reade, Cassidy Freitas, Lindsey Lawson

Year: 2014

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6336

Narratives of somatizing and non-somatizing patients in a primary care setting

Type: Journal Article

Authors: V. Elderkin-Thompson, R. C. Silver, H. Waitzkin

Year: 1998

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6337

NASN position statement: the role of the school nurse and school-based health centers

Type: Journal Article

Authors: A. Bannister, S. Kelts

Year: 2011

Publication Place: United States

Abstract: The National Association of School Nurses holds the position that a combination of school nursing services and school-based health centers (SBHCs) can facilitate positive health outcomes for students. SBHC services complement the work of the school nurses, who are responsible for the entire population of students, by providing a referral site for students without another medical home. SBHCs may provide primary nursing, medical, dental, mental health and other services to those students enrolled in the SBHC program. When available, SBHCs should be integrated with school nursing services to provide a continuum of health services to keep students healthy, in school, and ready to learn. Funding for SBHCs and school nurses typically comes from different sources, so the relationship should by complementary and not competitive.

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6338

National and State Treatment Need and Capacity for Opioid Agonist Medication-Assisted Treatment

Type: Journal Article

Authors: C. M. Jones, M. Campopiano, G. Baldwin, E. McCance-Katz

Year: 2015

Publication Place: United States

Abstract: OBJECTIVES: We estimated national and state trends in opioid agonist medication-assisted treatment (OA-MAT) need and capacity to identify gaps and inform policy decisions. METHODS: We generated national and state rates of past-year opioid abuse or dependence, maximum potential buprenorphine treatment capacity, number of patients receiving methadone from opioid treatment programs (OTPs), and the percentage of OTPs operating at 80% capacity or more using Substance Abuse and Mental Health Services Administration data. RESULTS: Nationally, in 2012, the rate of opioid abuse or dependence was 891.8 per 100 000 people aged 12 years or older compared with national rates of maximum potential buprenorphine treatment capacity and patients receiving methadone in OTPs of, respectively, 420.3 and 119.9. Among states and the District of Columbia, 96% had opioid abuse or dependence rates higher than their buprenorphine treatment capacity rates; 37% had a gap of at least 5 per 1000 people. Thirty-eight states (77.6%) reported at least 75% of their OTPs were operating at 80% capacity or more. CONCLUSIONS: Significant gaps between treatment need and capacity exist at the state and national levels. Strategies to increase the number of OA-MAT providers are needed.

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6339

National Association of Social Workers (NASW)

Type: Web Resource

Authors: National Association of Social Workers

Year: 2013

Publication Place: Washington, D.C.

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This grey literature reference is included in the Academy's Literature Collection in keeping with our mission to gather all sources of information on integration. Grey literature is comprised of materials that are not made available through traditional publishing avenues. Often, the information from unpublished resources can be limited and the risk of bias cannot be determined.

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6340

National Council awarded grant to establish training center

Type: Journal Article

Year: 2010

Publication Place: URL

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