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Opioids & SU

The Literature Collection contains over 10,000 references for published and grey literature on the integration of behavioral health and primary care. Learn More

Use the Search feature below to find references for your terms across the entire Literature Collection, or limit your searches by Authors, Keywords, or Titles and by Year, Type, or Topic. View your search results as displayed, or use the options to: Show more references per page; Sort references by Title or Date; and Refine your search criteria. Expand an individual reference to View Details. Full-text access to the literature may be available through a link to PubMed, a DOI, or a URL. References may also be exported for use in bibliographic software (e.g., EndNote, RefWorks, Zotero).

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221
Buprenorphine/naloxone and methadone maintenance treatment outcomes for opioid analgesic, heroin, and combined users: findings from starting treatment with agonist replacement therapies (START)
Type: Journal Article
Authors: J. S. Potter, E. N. Marino, M. P. Hillhouse, S. Nielsen, K. Wiest, C. P. Canamar, J. A. Martin, A. Ang, R. Baker, A. J. Saxon, W. Ling
Year: 2013
Publication Place: United States
Abstract: OBJECTIVE: The objective of this secondary analysis was to explore differences in baseline clinical characteristics and opioid replacement therapy treatment outcomes by type (heroin, opioid analgesic [OA], or combined [heroin and OA]) and route (injector or non-injector) of opioid use. METHOD: A total of 1,269 participants (32.2% female) were randomized to receive one of two study medications (methadone or buprenorphine/naloxone [BUP]). Of these, 731 participants completed the 24-week active medication phase. Treatment outcomes were opioid use during the final 30 days of treatment (among treatment completers) and treatment attrition. RESULTS: Non-opioid substance dependence diagnoses and injecting differentiated heroin and combined users from OA users. Non-opioid substance dependence diagnoses and greater heroin use differentiated injectors from non-injectors. Further, injectors were more likely to be using at end of treatment compared with non-injectors. OA users were more likely to complete treatment compared with heroin users and combined users. Non-injectors were more likely than injectors to complete treatment. There were no interactions between type of opioid used or injection status and treatment assignment (methadone or BUP) on either opioid use or treatment attrition. CONCLUSIONS: Findings indicate that substance use severity differentiates heroin users from OA users and injectors from non-injectors. Irrespective of medication, heroin use and injecting are associated with treatment attrition and opioid misuse during treatment. These results have particular clinical interest, as there is no evidence of superiority of BUP over methadone for treating OA users versus heroin users.
Topic(s):
Opioids & Substance Use See topic collection
222
Buprenorphine/Naloxone for Opioid Use Disorder Among Alaska Native and American Indian People
Type: Journal Article
Authors: Kate M. Lillie, Jennifer Shaw, Kelley J. Jansen, Michelle M. Garrison
Year: 2021
Publication Place: Baltimore, Maryland
Topic(s):
Education & Workforce See topic collection
,
Healthcare Disparities See topic collection
,
Opioids & Substance Use See topic collection
223
Buprenorphine/naloxone initiation and referral as a quality improvement intervention for patients who live with opioid use disorder: quantitative evaluation of provincial spread to 107 rural and urban Alberta emergency departments
Type: Journal Article
Authors: K. D. Stone, K. Scott, B. R. Holroyd, E. Lang, K. Yee, N. Taghizadeh, J. Deol, K. Dong, J. Fanaeian, M. Ghosh, K. Low, M. Ross, R. Tanguay, P. Faris, N. Day, P. McLane
Year: 2023
Topic(s):
Opioids & Substance Use See topic collection
224
Buprenorphine/naloxone treatment in primary care is associated with decreased human immunodeficiency virus risk behaviors
Type: Journal Article
Authors: Lynn E. Sullivan, Brent A. Moore, Marek C. Chawarski, Michael V. Pantalon, Declan Barry, Patrick G. O'Connor, Richard S. Schottenfeld, David A. Fiellin
Year: 2008
Topic(s):
Opioids & Substance Use See topic collection
225
Buprenorphine/naloxone versus methadone and lofexidine in community stabilisation and detoxification: A randomised controlled trial of low dose short-term opiate-dependent individuals
Type: Journal Article
Authors: F. D. Law, A. M. Diaper, J. K. Melichar, S. Coulton, D. J. Nutt, J. S. Myles
Year: 2017
Publication Place: United States
Abstract: Buprenorphine/naloxone, methadone and lofexidine are medications with utility in the treatment of opiate withdrawal. We report the first randomised controlled trial to compare the effects of these two medications on withdrawal symptoms and outcome during opiate induction/stabilisation and detoxification. A double-blind randomised controlled trial was conducted in an outpatient satellite clinic of a specialist drug service. Eighty opiate dependent individuals meeting DSM-IV criteria for opiate dependence, using (1/2) g heroin smoked/chased or (1/4) g heroin injected or 30mg methadone, with 3 years of opioid dependency, underwent a short-term opiate treatment programme involving induction/stabilisation on methadone 30mg or buprenorphine/naloxone 4mg/1mg, followed by detoxification (where the methadone group was assisted by lofexidine). The main outcome measures were urine drug screens for opiates and withdrawal and craving questionnaires. There were no overall differences in positive urine drug screens and drop-outs during any phase of the study. During induction/stabilisation, withdrawal symptoms subsided more slowly for buprenorphine/naloxone than for methadone, and craving was significantly higher in the buprenorphine/naloxone group ( p<0.05, 95% confidence interval -3.5, -0.38). During detoxification, withdrawal symptoms were significantly greater and the peak of withdrawal was earlier for the methadone/lofexidine group than the buprenorphine/naloxone group ( p<0.01, 95% confidence interval 3.0, 8.3). Methadone/lofexidine and buprenorphine/naloxone had comparable outcomes during rapid outpatient stabilisation and detoxification in low dose opiate users.
Topic(s):
Opioids & Substance Use See topic collection
226
Buprenorphine/naloxone versus methadone and lofexidine in community stabilisation and detoxification: A randomised controlled trial of low dose short-term opiate-dependent individuals
Type: Journal Article
Authors: F. D. Law, A. M. Diaper, J. K. Melichar, S. Coulton, D. J. Nutt, J. S. Myles
Year: 2017
Publication Place: United States
Abstract: Buprenorphine/naloxone, methadone and lofexidine are medications with utility in the treatment of opiate withdrawal. We report the first randomised controlled trial to compare the effects of these two medications on withdrawal symptoms and outcome during opiate induction/stabilisation and detoxification. A double-blind randomised controlled trial was conducted in an outpatient satellite clinic of a specialist drug service. Eighty opiate dependent individuals meeting DSM-IV criteria for opiate dependence, using (1/2) g heroin smoked/chased or (1/4) g heroin injected or 30mg methadone, with 3 years of opioid dependency, underwent a short-term opiate treatment programme involving induction/stabilisation on methadone 30mg or buprenorphine/naloxone 4mg/1mg, followed by detoxification (where the methadone group was assisted by lofexidine). The main outcome measures were urine drug screens for opiates and withdrawal and craving questionnaires. There were no overall differences in positive urine drug screens and drop-outs during any phase of the study. During induction/stabilisation, withdrawal symptoms subsided more slowly for buprenorphine/naloxone than for methadone, and craving was significantly higher in the buprenorphine/naloxone group ( p<0.05, 95% confidence interval -3.5, -0.38). During detoxification, withdrawal symptoms were significantly greater and the peak of withdrawal was earlier for the methadone/lofexidine group than the buprenorphine/naloxone group ( p<0.01, 95% confidence interval 3.0, 8.3). Methadone/lofexidine and buprenorphine/naloxone had comparable outcomes during rapid outpatient stabilisation and detoxification in low dose opiate users.
Topic(s):
Opioids & Substance Use See topic collection
227
CA Bridge Study Finds Emergency Department Buprenorphine Linked to Sustained Opioid Use Disorder Treatment
Type: Report
Authors: CA Bridge
Year: 2024
Publication Place: Oakland, CA
Topic(s):
Opioids & Substance Use See topic collection
,
Grey Literature See topic collection
Disclaimer:

This grey literature reference is included in the Academy's Literature Collection in keeping with our mission to gather all sources of information on integration. Grey literature is comprised of materials that are not made available through traditional publishing avenues. Often, the information from unpublished resources can be limited and the risk of bias cannot be determined.

228
Canadian guideline for safe and effective use of opioids for chronic noncancer pain: clinical summary for family physicians. Part 2: special populations
Type: Journal Article
Authors: M. Kahan, L. Wilson, A. Mailis-Gagnon, A. Srivastava, National Opioid Use Guideline Group
Year: 2011
Publication Place: Canada
Abstract: OBJECTIVE: To provide family physicians with a practical clinical summary of opioid prescribing for specific populations based on recommendations from the Canadian Guideline for Safe and Effective Use of Opioids for Chronic Non-Cancer Pain. QUALITY OF EVIDENCE: Researchers for the guideline conducted a systematic review of the literature, focusing on reviews of the effectiveness and safety of opioids in specific populations. MAIN MESSAGE: Family physicians can minimize the risks of overdose, sedation, misuse, and addiction through the use of strategies tailored to the age and health status of patients. For patients at high risk of addiction, opioids should be reserved for well-defined nociceptive or neuropathic pain conditions that have not responded to first-line treatments. Opioids should be titrated slowly, with frequent dispensing and close monitoring for signs of misuse. Suspected opioid addiction is managed with structured opioid therapy, methadone or buprenorphine treatment, or abstinence-based treatment. Patients with mood and anxiety disorders tend to have a blunted analgesic response to opioids, are at higher risk of misuse, and are often taking sedating drugs that interact adversely with opioids. Precautions similar to those for other high-risk patients should be employed. The opioid should be tapered if the patient's pain remains severe despite an adequate trial of opioid therapy. In the elderly, sedation, falls, and overdose can be minimized through lower initial doses, slower titration, benzodiazepine tapering, and careful patient education. For pregnant women taking daily opioid therapy, the opioids should be slowly tapered and discontinued. If this is not possible, they should be tapered to the lowest effective dose. Opioid-dependent pregnant women should receive methadone treatment. Adolescents are at high risk of opioid overdose, misuse, and addiction. Patients with adolescents living at home should store their opioid medication safely. Adolescents rarely require long-term opioid therapy. CONCLUSION: Family physicians must take into consideration the patient's age, psychiatric status, level of risk of addiction, and other factors when prescribing opioids for chronic pain.
Topic(s):
Opioids & Substance Use See topic collection
,
Education & Workforce See topic collection
229
Care Practices of Mental Health Clinical Pharmacist Practitioners Within an Interdisciplinary Primary Care Model for Patients With Substance Use Disorders
Type: Journal Article
Authors: A. Percy, A. T. Kelley, N. Valentino, A. Butz, J. D. Baylis, Y. Suo, A. J. Gordon, A. L. Jones
Year: 2023
Abstract:

BACKGROUND: Clinical pharmacist practitioners (CPPs) play an increasingly important role in interdisciplinary care for patients with substance use disorders (SUDs). However, CPPs' scope of practice varies substantially across clinics and settings. OBJECTIVES: We sought to describe CPP practices and activities within an interdisciplinary, team-based primary care clinic dedicated to treat Veterans with histories of substance use disorders, experience of homelessness, high medical complexity, and other vulnerabilities. METHODS: We conducted a retrospective cohort study of CPP activities using Department of Veterans Affairs (VA) administrative data in 2019. RESULTS: CPPs provided care for 228 patients, including 766 in-clinic visits, 341 telephone visits, and 626 chart reviews, with an average of 2.5 hours spent per patient per year. Patients seen by CPPs frequently experience mental health conditions and SUDs, including depression (66%), post-traumatic stress disorder (52%), opioid use disorder (OUD) (45%), and alcohol use disorder (44%). CPPs managed buprenorphine medications for OUD or chronic pain in 76 patients (33%). Most CPP interventions (3330 total) were for SUDs (33%), mental health conditions (24%), and pain management (24%), with SUD interventions including medication initiation, dose changes, discontinuations and monitoring. As part of opioid risk mitigation efforts, CPPs queried the state's prescription drug monitoring program 769 times and ordered 59 naloxone kits and 661 lab panels for empaneled patients. CONCLUSION: CPPs managed a high volume of vulnerable patients and provided complex care within an interdisciplinary primary care team. Similar CPP roles could be implemented in other primary care settings to increase access to SUD treatment.

Topic(s):
Opioids & Substance Use See topic collection
,
Education & Workforce See topic collection
,
Healthcare Disparities See topic collection
230
Care Practices of Mental Health Clinical Pharmacist Practitioners Within an Interdisciplinary Primary Care Model for Patients With Substance Use Disorders
Type: Journal Article
Authors: A. Percy, A. T. Kelley, N. Valentino, A. Butz, J. D. Baylis, Y. Suo, A. J. Gordon, A. L. Jones
Year: 2023
Abstract:

BACKGROUND: Clinical pharmacist practitioners (CPPs) play an increasingly important role in interdisciplinary care for patients with substance use disorders (SUDs). However, CPPs' scope of practice varies substantially across clinics and settings. OBJECTIVES: We sought to describe CPP practices and activities within an interdisciplinary, team-based primary care clinic dedicated to treat Veterans with histories of substance use disorders, experience of homelessness, high medical complexity, and other vulnerabilities. METHODS: We conducted a retrospective cohort study of CPP activities using Department of Veterans Affairs (VA) administrative data in 2019. RESULTS: CPPs provided care for 228 patients, including 766 in-clinic visits, 341 telephone visits, and 626 chart reviews, with an average of 2.5 hours spent per patient per year. Patients seen by CPPs frequently experience mental health conditions and SUDs, including depression (66%), post-traumatic stress disorder (52%), opioid use disorder (OUD) (45%), and alcohol use disorder (44%). CPPs managed buprenorphine medications for OUD or chronic pain in 76 patients (33%). Most CPP interventions (3330 total) were for SUDs (33%), mental health conditions (24%), and pain management (24%), with SUD interventions including medication initiation, dose changes, discontinuations and monitoring. As part of opioid risk mitigation efforts, CPPs queried the state's prescription drug monitoring program 769 times and ordered 59 naloxone kits and 661 lab panels for empaneled patients. CONCLUSION: CPPs managed a high volume of vulnerable patients and provided complex care within an interdisciplinary primary care team. Similar CPP roles could be implemented in other primary care settings to increase access to SUD treatment.

Topic(s):
Education & Workforce See topic collection
,
Opioids & Substance Use See topic collection
231
CareConnect: Adapting a Virtual Urgent Care Model to Provide Buprenorphine Transitional Care
Type: Journal Article
Authors: Margaret Lowenstein, Nicole O'Donnell, Jasmine Barnes, Kathryn Gallagher, Gilly Gehri, Jon K. Pomeroy, Shoshana Aronowitz, Krisda Chaiyachati, Emily Cubbage, Rachel French, Susan McGinley, Brittany Salerno, Jeanmarie Perrone
Year: 2022
Topic(s):
Opioids & Substance Use See topic collection
,
HIT & Telehealth See topic collection
,
Education & Workforce See topic collection
232
Cascade of care for office-based buprenorphine treatment in Bronx community clinics
Type: Journal Article
Authors: L. Khalid, C. O. Cunningham, Y. Deng, M. Masyukova, J. Bumol, A. Valle, C. Zhang, T. Lu
Year: 2022
Publication Place: United States
Topic(s):
Education & Workforce See topic collection
,
Healthcare Disparities See topic collection
,
Opioids & Substance Use See topic collection
233
Case management: ongoing evaluation of patients' needs in an opioid treatment program
Type: Journal Article
Authors: P. J. Abbott
Year: 2010
Publication Place: United States
Abstract: PURPOSE/OBJECTIVE: Case management has been widely used in mental health and substance abuse services. There have been only a few studies that have examined the use of case management in opioid-treatment programs. In a project funded by the Centers of Substance Abuse Treatment, we looked at the use of case managers and specifically at the treatment needs of this unique population. Our case managers, with the aid of research assistants, surveyed the treatment needs of 189 patients entering an opioid-treatment program over a 3-year period. Patients completed the Needs Assessment Instrument at intake, 6 months, and 12 months. PRIMARY PRACTICE SETTING(S): The use of case managers to assess the needs of opioid-dependent patients is applicable to substance abuse treatment setting especially in opioid-treatment programs that provide methadone or buprenorphine maintenance. FINDINGS/CONCLUSIONS: The critical services most requested were vocational, employment, transportation, dental, emotional, and smoking cessation. There were changes over the 12-month follow-up period in the types and priority of services requested. IMPLICATION FOR CASE MANAGEMENT PRACTICE: The Needs Assessment Instrument is a useful tool for case mangers to assess treatment needs of patients and the overall clinic population. Once sufficient patients have been surveyed, the opioid-treatment program can plan needed services for the clinic. Specific social agencies can be contacted to provide key services. Service needs are not static and as patients improve they may need a different mix of services to support their continued abstinence.
Topic(s):
Opioids & Substance Use See topic collection
,
Education & Workforce See topic collection
234
CDC Guideline for Prescribing Opioids for Chronic Pain--United States, 2016
Type: Journal Article
Authors: D. Dowell, T. M. Haegerich, R. Chou
Year: 2016
Publication Place: United States
Abstract: IMPORTANCE: Primary care clinicians find managing chronic pain challenging. Evidence of long-term efficacy of opioids for chronic pain is limited. Opioid use is associated with serious risks, including opioid use disorder and overdose. OBJECTIVE: To provide recommendations about opioid prescribing for primary care clinicians treating adult patients with chronic pain outside of active cancer treatment, palliative care, and end-of-life care. PROCESS: The Centers for Disease Control and Prevention (CDC) updated a 2014 systematic review on effectiveness and risks of opioids and conducted a supplemental review on benefits and harms, values and preferences, and costs. CDC used the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) framework to assess evidence type and determine the recommendation category. EVIDENCE SYNTHESIS: Evidence consisted of observational studies or randomized clinical trials with notable limitations, characterized as low quality using GRADE methodology. Meta-analysis was not attempted due to the limited number of studies, variability in study designs and clinical heterogeneity, and methodological shortcomings of studies. No study evaluated long-term (>/=1 year) benefit of opioids for chronic pain. Opioids were associated with increased risks, including opioid use disorder, overdose, and death, with dose-dependent effects. RECOMMENDATIONS: There are 12 recommendations. Of primary importance, nonopioid therapy is preferred for treatment of chronic pain. Opioids should be used only when benefits for pain and function are expected to outweigh risks. Before starting opioids, clinicians should establish treatment goals with patients and consider how opioids will be discontinued if benefits do not outweigh risks. When opioids are used, clinicians should prescribe the lowest effective dosage, carefully reassess benefits and risks when considering increasing dosage to 50 morphine milligram equivalents or more per day, and avoid concurrent opioids and benzodiazepines whenever possible. Clinicians should evaluate benefits and harms of continued opioid therapy with patients every 3 months or more frequently and review prescription drug monitoring program data, when available, for high-risk combinations or dosages. For patients with opioid use disorder, clinicians should offer or arrange evidence-based treatment, such as medication-assisted treatment with buprenorphine or methadone. CONCLUSIONS AND RELEVANCE: The guideline is intended to improve communication about benefits and risks of opioids for chronic pain, improve safety and effectiveness of pain treatment, and reduce risks associated with long-term opioid therapy.
Topic(s):
Opioids & Substance Use See topic collection
,
Healthcare Policy See topic collection
,
Education & Workforce See topic collection
235
Challenges and Opportunities for the Use of Medications to Treat Opioid Addiction in the United States and Other Nations of the World
Type: Journal Article
Authors: M. W. Parrino, A. G. Maremmani, P. N. Samuels, I. Maremmani
Year: 2015
Publication Place: England
Abstract: There has been a well documented increase in the use and abuse of prescription opioids and heroin in the United States and other parts of the world. There has also been an increasing focus to increase access to the use of medications (methadone, buprenorphine, Naltrexone/Vivitrol) for opioid addicted individuals under legal supervision. As policymakers engage in strategic initiatives to better prevent and effectively treat chronic opioid addiction, both in the United States and other countries, there are a number of unintended consequences, complicating how best to increase access to effective treatment.
Topic(s):
Opioids & Substance Use See topic collection
236
Challenges on the road to recovery: Exploring attitudes and experiences of clients in a community-based buprenorphine program in Baltimore City
Type: Journal Article
Authors: C. Truong, N. Krawczyk, M. Dejman, S. Marshall-Shah, K. Tormohlen, D. Agus, J. Bass
Year: 2019
Topic(s):
Education & Workforce See topic collection
,
Healthcare Disparities See topic collection
,
Opioids & Substance Use See topic collection
237
Change in opioid and buprenorphine prescribers and prescriptions by specialty, 2016–2021
Type: Journal Article
Authors: Marc R. Larochelle, Christopher M. Jones, Kun Zhang
Year: 2023
Topic(s):
Opioids & Substance Use See topic collection
,
Education & Workforce See topic collection
238
Changes in buprenorphine visits in frontier and remote locations: Effects of the SARS-CoV-2 pandemic
Type: Journal Article
Authors: L. M. McFadden
Year: 2023
Topic(s):
Opioids & Substance Use See topic collection
,
Healthcare Disparities See topic collection
239
Changes in buprenorphine waivered provider supply after Virginia Medicaid implements the addiction and recovery treatment services program and Medicaid expansion
Type: Journal Article
Authors: A. F. Urmi, E. Britton, H. Saunders, A. Harrell, C. Bachireddy, J. Lowe, A. J. Barnes, P. Cunningham
Year: 2024
Topic(s):
Opioids & Substance Use See topic collection
,
Financing & Sustainability See topic collection
,
Healthcare Policy See topic collection
240
Changes in For-Profit Medication-Assisted Therapy Clinics in an Appalachian City
Type: Journal Article
Authors: H. D. Holt, M. Olsen
Year: 2021
Publication Place: United States
Abstract:

OBJECTIVES: This study is a follow-up to previous research regarding buprenorphine medication-assisted therapy (MAT) in Johnson City, Tennessee. For-profit MAT clinics were surveyed to determine changes in tapering practice patterns and insurance coverage during the last 3 years. METHODS: Johnson City for-profit MAT clinics; also called office based opioid treatment centers, were surveyed by telephone. Clinic representatives were asked questions regarding patient costs for therapy, insurance coverage, counseling offered onsite, and opportunities for tapering while pregnant. RESULTS: All of the MAT clinics representatives indicated that tapering in pregnancy could be considered even though tapering in pregnancy is contrary to current national guidelines. Forty-three percent of the clinics now accept insurance as compared with 0% in the 2016 study. The average weekly cost per visit remained consistent. CONCLUSIONS: The concept of tapering buprenorphine during pregnancy appears to have become a standard of care for this community, as representatives state it is offered at all of the clinics that were contacted. Representatives from three clinics stated the clinics require tapering, even though national organizations such as the American College of Obstetricians and Gynecologists and the American Society of Addiction Medicine do not recommend this approach. Although patients who have government or other insurance are now able to obtain buprenorphine with no expense at numerous clinics, the high cost for uninsured patients continues to create an environment conducive to buprenorphine diversion.

Topic(s):
Education & Workforce See topic collection
,
Financing & Sustainability See topic collection
,
Healthcare Disparities See topic collection
,
Opioids & Substance Use See topic collection