The Agency for Healthcare Research and Quality (AHRQ) intends to publish a Request for Applications (RFA) to improve the management of opioids and opioid use disorder in older adults. AHRQ’s research has shown that hospitalizations and emergency department visits related to opioids are rapidly increasing among older adults. It is known that older adults may be uniquely at risk of adverse outcomes due to polypharmacy, comorbidities, other age-related conditions, and social stigma and expectations. However, relatively little guidance is available to help clinicians and health systems optimize outcomes related to pain, function, and substance use in this population. Applicants will be expected to develop a comprehensive model that uses evidence-based interventions and quality improvement strategies designed to improve the management of pain, opioid use, and opioid use disorder for older adults in primary care.