Operationalizing a Definition of Precipitated Withdrawal and the Absorption, Distribution, Metabolism, and Elimination of Illicitly Manufactured Fentanyl

This seven-hour webinar series from the Opioid Response Network (OPN) and American Osteopathic Academy of Addiction Medicine (AOAAM) will explore issues related to fentanyl use, including overdoses, xylazine, precipitated withdrawal, and the treatment of opioid use disorder using buprenorphine. Additionally, a new diagnostic and therapeutic approach regarding the treatment of methamphetamine use disorder will be discussed. This session is the third of seven webinars in the series.

Description:

This webinar will discuss challenges of illicit fentanyl consumption. The data presented will discuss a recent operational definition of precipitated opioid withdrawal, drawn from an empirical study, and will introduce how the unique absorption, distribution, metabolization, and excretion of fentanyl may be contributing to fentanyl's unique profile of effects in patients.

Learning Objectives:

At the conclusion of the seminar learners will be able to:

1. Learn about the peripheral distribution and excretion patterns of fentanyl
2. Understand how fentanyl may be interacting in unique ways with buprenorphine 
3. Learn the operational definition for differentiating precipitated from spontaneous opioid withdrawal