TY - JOUR
KW - Analgesics, Opioid/administration & dosage/adverse effects/therapeutic use
KW - Benzodiazepines
KW - Benzodiazepines/administration & dosage/adverse effects/therapeutic use
KW - Chronic Pain
KW - Chronic Pain/drug therapy
KW - Drug overdose
KW - Drug Therapy, Combination
KW - Humans
KW - Mortality
KW - Opioid analgesics
KW - Opioid-Related Disorders/etiology/prevention & control
KW - Practice Patterns, Physicians'
KW - Risk
KW - therapeutic use
AU - L. R. Webster
AU - G. M. Reisfield
AU - N. Dasgupta
A1 - 
AB - The provision of long-term opioid analgesic therapy for chronic pain requires a careful risk/benefit analysis followed by clinical safety measures to identify and reduce misuse, abuse, and addiction and their associated morbidity and mortality. Multiple data sources show that benzodiazepines, prescribed for comorbid insomnia, anxiety, and mood disorders, heighten the risk of respiratory depression and other adverse outcomes when combined with opioid therapy. Evidence is presented for hazards associated with coadministration of opioids and benzodiazepines and the need for caution when initiating opioid therapy for chronic pain. Clinical recommendations follow, as drawn from 2 previously published literature reviews, one of which proffers 8 principles for safer opioid prescribing; the other review presents risks associated with benzodiazepines, suggests alternatives for co-prescribing benzodiazepines and opioids, and outlines recommendations regarding co-prescribing if alternative therapies are ineffective.
BT - Postgraduate medicine
C5 - Opioids & Substance Use; Education & Workforce
CP - 1
CY - England
IS - 1
JF - Postgraduate medicine
N2 - The provision of long-term opioid analgesic therapy for chronic pain requires a careful risk/benefit analysis followed by clinical safety measures to identify and reduce misuse, abuse, and addiction and their associated morbidity and mortality. Multiple data sources show that benzodiazepines, prescribed for comorbid insomnia, anxiety, and mood disorders, heighten the risk of respiratory depression and other adverse outcomes when combined with opioid therapy. Evidence is presented for hazards associated with coadministration of opioids and benzodiazepines and the need for caution when initiating opioid therapy for chronic pain. Clinical recommendations follow, as drawn from 2 previously published literature reviews, one of which proffers 8 principles for safer opioid prescribing; the other review presents risks associated with benzodiazepines, suggests alternatives for co-prescribing benzodiazepines and opioids, and outlines recommendations regarding co-prescribing if alternative therapies are ineffective.
PP - England
PY - 2015
SN - 1941-9260; 0032-5481
SP - 27
EP - 32
EP - 
T1 - Eight principles for safer opioid prescribing and cautions with benzodiazepines
T2 - Postgraduate medicine
TI - Eight principles for safer opioid prescribing and cautions with benzodiazepines
U1 - Opioids & Substance Use; Education & Workforce
U2 - 25526233
VL - 127
VO - 1941-9260; 0032-5481
Y1 - 2015
ER -