TY - JOUR
KW - Adult
KW - Age Factors
KW - Analgesics, Opioid/adverse effects
KW - Blood Glucose/analysis
KW - Confidence Intervals
KW - Diabetes Mellitus/etiology/virology
KW - Female
KW - Hepatitis C/complications
KW - HIV Infections/complications
KW - Humans
KW - Incidence
KW - Logistic Models
KW - Middle Aged
KW - Odds Ratio
KW - Opioid-Related Disorders/complications
KW - Prevalence
KW - Proportional Hazards Models
KW - Prospective Studies
KW - Risk Factors
AU - A. A. Howard
AU - D. R. Hoover
AU - K. Anastos
AU - X. Wu
AU - Q. Shi
AU - H. D. Strickler
AU - S. R. Cole
AU - M. H. Cohen
AU - A. Kovacs
AU - M. Augenbraun
AU - P. S. Latham
AU - P. C. Tien
A1 - 
AB - BACKGROUND: Opiate use is common in HIV-infected and hepatitis C virus (HCV)-infected individuals, however, its contribution to the risk of diabetes mellitus is not well understood. METHODS: Prospective study of 1713 HIV-infected and 652 HIV-uninfected participants from the Women's Interagency HIV Study between October 2000 and March 2006. Diabetes defined as fasting glucose > or =126 mg/dL, self report of diabetes medication use, or confirmed diabetes diagnosis. Opiate use determined using an interviewer-administered questionnaire. Detectable plasma HCV RNA confirmed HCV infection. RESULTS: Current opiate users had a higher prevalence of diabetes (15%) than nonusers (10%, P = 0.03), and a higher risk of incident diabetes (adjusted relative hazard: 1.58, 95% confidence interval: 1.01 to 2.46), after controlling for HCV infection, HIV/antiretroviral therapy status, and diabetes risk factors including age, race/ethnicity, family history of diabetes, and body mass index. HCV infection was also an independent risk factor for diabetes (adjusted relative hazard: 1.61, 95% confidence interval: 1.02 to 2.52). HCV-infected women reporting current opiate use had the highest diabetes incidence (4.83 cases per 100 person-years). CONCLUSIONS: Among women with or at-risk for HIV, opiate use is associated with increased diabetes risk independently of HCV infection. Diabetic screening should be part of care for opiate users and those infected with HCV.
BT - Journal of acquired immune deficiency syndromes (1999)
C5 - Opioids & Substance Use
CP - 2
CY - United States
DO - 10.1097/QAI.0b013e3181d0c911
IS - 2
JF - Journal of acquired immune deficiency syndromes (1999)
N2 - BACKGROUND: Opiate use is common in HIV-infected and hepatitis C virus (HCV)-infected individuals, however, its contribution to the risk of diabetes mellitus is not well understood. METHODS: Prospective study of 1713 HIV-infected and 652 HIV-uninfected participants from the Women's Interagency HIV Study between October 2000 and March 2006. Diabetes defined as fasting glucose > or =126 mg/dL, self report of diabetes medication use, or confirmed diabetes diagnosis. Opiate use determined using an interviewer-administered questionnaire. Detectable plasma HCV RNA confirmed HCV infection. RESULTS: Current opiate users had a higher prevalence of diabetes (15%) than nonusers (10%, P = 0.03), and a higher risk of incident diabetes (adjusted relative hazard: 1.58, 95% confidence interval: 1.01 to 2.46), after controlling for HCV infection, HIV/antiretroviral therapy status, and diabetes risk factors including age, race/ethnicity, family history of diabetes, and body mass index. HCV infection was also an independent risk factor for diabetes (adjusted relative hazard: 1.61, 95% confidence interval: 1.02 to 2.52). HCV-infected women reporting current opiate use had the highest diabetes incidence (4.83 cases per 100 person-years). CONCLUSIONS: Among women with or at-risk for HIV, opiate use is associated with increased diabetes risk independently of HCV infection. Diabetic screening should be part of care for opiate users and those infected with HCV.
PP - United States
PY - 2010
SN - 1944-7884; 1525-4135
SP - 152
EP - 159
EP - 
T1 - The effects of opiate use and hepatitis C virus infection on risk of diabetes mellitus in the Women's Interagency HIV Study
T2 - Journal of acquired immune deficiency syndromes (1999)
TI - The effects of opiate use and hepatitis C virus infection on risk of diabetes mellitus in the Women's Interagency HIV Study
U1 - Opioids & Substance Use
U2 - 20190642
U3 - 10.1097/QAI.0b013e3181d0c911
VL - 54
VO - 1944-7884; 1525-4135
Y1 - 2010
ER -