TY - JOUR
KW - Adverse Drug Reaction Reporting Systems
KW - Aged
KW - Drug Prescriptions/standards
KW - Drug Therapy/adverse effects
KW - Drug Toxicity/epidemiology
KW - Drug Utilization/standards
KW - Hospitalization/statistics & numerical data
KW - Hospitals, University/utilization
KW - Humans
KW - internal medicine
KW - Medical Records Systems, Computerized
KW - Middle Aged
KW - Pharmacoepidemiology/methods
KW - Pilot Projects
KW - Sweden/epidemiology
AU - M. von Euler
AU - E. Eliasson
AU - G. Ohlen
AU - U. Bergman
A1 - 
AB - PURPOSE: To use computerized medical records to study the frequency of adverse drug reactions (ADR) as a cause for acute admission to a university hospital. METHODS: Computerized medical records in 168 consecutively acutely admitted cases to a short-term internal medicine ward at a university hospital were retrospectively evaluated to see if an ADR could have caused the admission. RESULTS: In 18 cases (11%), an ADR was judged to be the reason for acute admission to the hospital. Augmented pharmacological effects (type A reactions) accounted for 89% of the cases. An additional eight cases (5%) were intentional intoxications with prescription drugs. ADR-associated hospital admissions were age-related (average age 72 compared to 65 in patients admitted for other reasons) and also associated with poly-pharmacy (8.3 drugs compared to 5.2). The ADR was considered to arise from a drug-drug interaction in four cases (22%). Although all ADRs fulfilled the criteria for mandatory reporting, none of them were reported to the Swedish Adverse Drug Reactions Advisory Committee (SADRAC). CONCLUSIONS: The observed frequency of ADR-related acute hospital admissions in this pilot study is similar to earlier reported data from Sweden and abroad. Almost all of these reactions were known pharmacological (type A) reactions and many therefore theoretically preventable. In contrast to many prospective and costly studies, this retrospective analysis of computerized medical records offered a simple method that can be used in routine health care and also serve as an indicator of the quality of drug use.
BT - Pharmacoepidemiology and drug safety
C5 - HIT & Telehealth
CP - 3
CY - England
DO - 10.1002/pds.1154
IS - 3
JF - Pharmacoepidemiology and drug safety
N2 - PURPOSE: To use computerized medical records to study the frequency of adverse drug reactions (ADR) as a cause for acute admission to a university hospital. METHODS: Computerized medical records in 168 consecutively acutely admitted cases to a short-term internal medicine ward at a university hospital were retrospectively evaluated to see if an ADR could have caused the admission. RESULTS: In 18 cases (11%), an ADR was judged to be the reason for acute admission to the hospital. Augmented pharmacological effects (type A reactions) accounted for 89% of the cases. An additional eight cases (5%) were intentional intoxications with prescription drugs. ADR-associated hospital admissions were age-related (average age 72 compared to 65 in patients admitted for other reasons) and also associated with poly-pharmacy (8.3 drugs compared to 5.2). The ADR was considered to arise from a drug-drug interaction in four cases (22%). Although all ADRs fulfilled the criteria for mandatory reporting, none of them were reported to the Swedish Adverse Drug Reactions Advisory Committee (SADRAC). CONCLUSIONS: The observed frequency of ADR-related acute hospital admissions in this pilot study is similar to earlier reported data from Sweden and abroad. Almost all of these reactions were known pharmacological (type A) reactions and many therefore theoretically preventable. In contrast to many prospective and costly studies, this retrospective analysis of computerized medical records offered a simple method that can be used in routine health care and also serve as an indicator of the quality of drug use.
PP - England
PY - 2006
SN - 1053-8569; 1053-8569
SP - 179
EP - 184
EP - 
T1 - Adverse drug reactions causing hospitalization can be monitored from computerized medical records and thereby indicate the quality of drug utilization
T2 - Pharmacoepidemiology and drug safety
TI - Adverse drug reactions causing hospitalization can be monitored from computerized medical records and thereby indicate the quality of drug utilization
U1 - HIT & Telehealth
U3 - 10.1002/pds.1154
VL - 15
VO - 1053-8569; 1053-8569
Y1 - 2006
ER -