TY - JOUR AU - A. I. Roche AU - B. L. Straub AU - E. B. K. Thomas AU - H. M. Eadeh AU - K. A. Schofield AU - A. M. Chamberlain AU - R. M. Jacobson AU - A. N. Lass AU - J. Bailey AU - K. Vickers AU - R. M. Merwin AU - C. N. Sawchuk A1 - AB - BACKGROUND: Single-session interventions offer a novel approach to improving access to evidence-based mental health services using a population-based framework for delivery. The current single-arm pilot study aimed to assess the feasibility, acceptability, and preliminary effectiveness of a single-session intervention in Mayo Clinic's primary care Integrated Behavioral Health program.. METHODS: Participants were recruited from Mayo Clinic's Integrated Behavioral Health program and participated in a therapist-delivered single-session therapy intervention in primary care. The intervention could be delivered by video or in-person and was based on acceptance and commitment therapy and solution-focused brief therapy principles. Descriptive statistics and 2-tailed paired sampled t-tests were used to examine outcomes. RESULTS: Less than 20% of the patients contacted expressed interest in the study; however, the majority who expressed interest and screened eligible completed the single-session therapy visit (N = 34). Acceptability was high, as indicated by study participants expressing generally high levels of satisfaction with the single visit. Participants experienced significant increases from pre- to post-intervention in readiness for change and in self-reported capacity to generate pathways toward goals. From pre-intervention to two-week follow-up, participants experienced significant reductions in depression and anxiety symptoms, significant increases in psychological flexibility and values progress, and significant decreases in values obstruction. CONCLUSIONS: Single-session interventions may be one helpful approach among a menu of stepped care options in primary care. Future work will benefit from ongoing exploration of the most appropriate processes for implementation of single-session interventions in primary care. TRIAL REGISTRATION: The study is registered at ClinicalTrials.gov (NCT06347822); Registration Date: 03/29/2024. AD - Department of Psychiatry and Psychology, Division of Integrated Behavioral Health, Mayo Clinic, 200 First Street SW, MN, Rochester, 55905, USA. roche.anne@mayo.edu.; Department of Nursing, Division of Social Work, Mayo Clinic, Rochester, MN, USA.; Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IA, USA.; Department of Medicine, Hennepin Healthcare Research Institute, Minneapolis, MN, USA.; Department of Psychiatry and Psychology, Division of Integrated Behavioral Health, Mayo Clinic, 200 First Street SW, MN, Rochester, 55905, USA.; Department of Quantitative Health Sciences, Division of Epidemiology, Mayo Clinic, Rochester, MN, USA.; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.; Department of Pediatric and Adolescent Medicine, Division of Community Pediatric and Adolescent Medicine, Division of Pediatric Infectious Diseases, Mayo Clinic, Rochester, MN, USA.; Sanford Health, Behavioral Health, Moorhead, MN, USA.; Division of Integrated Behavioral Health, Mayo Clinic Health System, Red Wing, MN, USA.; Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, USA. AN - 42151859 BT - BMC Prim Care C5 - Education & Workforce CP - 1 DA - 05/2026 DO - 10.1186/s12875-026-03361-y DP - NLM ET - 20260518 IS - 1 JF - BMC Prim Care LA - eng N2 - BACKGROUND: Single-session interventions offer a novel approach to improving access to evidence-based mental health services using a population-based framework for delivery. The current single-arm pilot study aimed to assess the feasibility, acceptability, and preliminary effectiveness of a single-session intervention in Mayo Clinic's primary care Integrated Behavioral Health program.. METHODS: Participants were recruited from Mayo Clinic's Integrated Behavioral Health program and participated in a therapist-delivered single-session therapy intervention in primary care. The intervention could be delivered by video or in-person and was based on acceptance and commitment therapy and solution-focused brief therapy principles. Descriptive statistics and 2-tailed paired sampled t-tests were used to examine outcomes. RESULTS: Less than 20% of the patients contacted expressed interest in the study; however, the majority who expressed interest and screened eligible completed the single-session therapy visit (N = 34). Acceptability was high, as indicated by study participants expressing generally high levels of satisfaction with the single visit. Participants experienced significant increases from pre- to post-intervention in readiness for change and in self-reported capacity to generate pathways toward goals. From pre-intervention to two-week follow-up, participants experienced significant reductions in depression and anxiety symptoms, significant increases in psychological flexibility and values progress, and significant decreases in values obstruction. CONCLUSIONS: Single-session interventions may be one helpful approach among a menu of stepped care options in primary care. Future work will benefit from ongoing exploration of the most appropriate processes for implementation of single-session interventions in primary care. TRIAL REGISTRATION: The study is registered at ClinicalTrials.gov (NCT06347822); Registration Date: 03/29/2024. PY - 2026 SN - 2731-4553 ST - Implementation of a single session psychotherapy intervention in primary care integrated behavioral health: a single-arm pilot study T1 - Implementation of a single session psychotherapy intervention in primary care integrated behavioral health: a single-arm pilot study T2 - BMC Prim Care TI - Implementation of a single session psychotherapy intervention in primary care integrated behavioral health: a single-arm pilot study U1 - Education & Workforce U3 - 10.1186/s12875-026-03361-y VL - 27 VO - 2731-4553 Y1 - 2026 ER -