TY - JOUR AU - C. Di Vincenzo AU - F. Demaria AU - I. Bertoncini AU - D. Menghini AU - A. Antonietti AU - S. Vicari AU - M. Pontillo A1 - AB - Pediatric obsessive-compulsive disorder (OCD) is a complex condition that typically emerges in childhood or adolescence and is closely linked to developmental changes in cognitive and emotional control. This mini-review offers a clinically oriented synthesis of pediatric OCD from a developmental and transdiagnostic perspective, framing it as a disturbance of flexibility, inhibition, and distress regulation that organizes its clinical presentation. Variations in these control processes across development shape the content and form of obsessive-compulsive symptoms and contribute to their frequent overlap with conditions such as autism spectrum disorder, tic disorders and Tourettic OCD, ADHD, bipolar disorder, and psychosis-risk presentations, which share similar regulatory vulnerabilities. Within this framework, family accommodation is conceptualized as an interpersonal extension of the child's regulatory difficulties, temporarily reducing distress while reinforcing reliance on external control. A transdiagnostic focus on underlying regulatory mechanisms also helps to clarify why interventions such as developmentally adapted cognitive-behavioral therapy with exposure and response prevention, family-focused treatments, and process-based transdiagnostic protocols can promote more flexible cognitive-emotional regulation in both the child and the family system. Taken together, these elements support a developmental, family-integrated, and transdiagnostic conceptualization of pediatric OCD centered on cognitive-emotional control. AD - Department of Psychology, Catholic University of Sacred Hearth, Milan, Italy.; Child and Adolescent Neuropsychiatry Unit, Bambino Gesù Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico/Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), Rome, Italy.; Department of Life Sciences and Public Health, Catholic University of the Sacred Hearth, Rome, Italy. AN - 41625616 BT - Front Psychiatry C5 - Healthcare Disparities DO - 10.3389/fpsyt.2025.1750938 DP - NLM ET - 20260116 JF - Front Psychiatry LA - eng N2 - Pediatric obsessive-compulsive disorder (OCD) is a complex condition that typically emerges in childhood or adolescence and is closely linked to developmental changes in cognitive and emotional control. This mini-review offers a clinically oriented synthesis of pediatric OCD from a developmental and transdiagnostic perspective, framing it as a disturbance of flexibility, inhibition, and distress regulation that organizes its clinical presentation. Variations in these control processes across development shape the content and form of obsessive-compulsive symptoms and contribute to their frequent overlap with conditions such as autism spectrum disorder, tic disorders and Tourettic OCD, ADHD, bipolar disorder, and psychosis-risk presentations, which share similar regulatory vulnerabilities. Within this framework, family accommodation is conceptualized as an interpersonal extension of the child's regulatory difficulties, temporarily reducing distress while reinforcing reliance on external control. A transdiagnostic focus on underlying regulatory mechanisms also helps to clarify why interventions such as developmentally adapted cognitive-behavioral therapy with exposure and response prevention, family-focused treatments, and process-based transdiagnostic protocols can promote more flexible cognitive-emotional regulation in both the child and the family system. Taken together, these elements support a developmental, family-integrated, and transdiagnostic conceptualization of pediatric OCD centered on cognitive-emotional control. PY - 2025 SN - 1664-0640 (Print); 1664-0640 SP - 1750938 ST - Pediatric obsessive-compulsive disorder as a developmental disorder of cognitive-emotional control: a transdiagnostic and family-integrated perspective T1 - Pediatric obsessive-compulsive disorder as a developmental disorder of cognitive-emotional control: a transdiagnostic and family-integrated perspective T2 - Front Psychiatry TI - Pediatric obsessive-compulsive disorder as a developmental disorder of cognitive-emotional control: a transdiagnostic and family-integrated perspective U1 - Healthcare Disparities U3 - 10.3389/fpsyt.2025.1750938 VL - 16 VO - 1664-0640 (Print); 1664-0640 Y1 - 2025 ER -