TY - JOUR
AU - M. Leveroni
AU - S. Jones
AU - S. Bell
A1 - 
AB - Depression is a prevalent and increasing concern in primary care, particularly among adolescents. Evidence supports routine screening, which improves remission and symptom reduction in adults and perinatal populations. Both psychotherapy and pharmacotherapy are effective first-line treatments, with similar efficacy in reducing symptoms. Selective serotonin reuptake inhibitors (SSRIs) remain the preferred outpatient antidepressant, demonstrating superiority over placebo and comparable outcomes to other agents. Generally safe for pregnant, breastfeeding, and geriatric patients, SSRIs require thoughtful selection based on side effects, contraindications, and patient preferences. Primary care clinicians are central to providing individualized, evidence-based, and patient-centered management of depression.
AD - UCI Family Health Center, 800 N. Main Street, Santa Ana, CA 92701, USA; University of California- Irvine Department of Family Medicine, 200 S. Manchester Avenue, Suite 835, Orange, CA 92868, USA. Electronic address: mleveron@hs.uci.edu.; UCI Family Health Center, 800 N. Main Street, Santa Ana, CA 92701, USA; University of California- Irvine Department of Family Medicine, 200 S. Manchester Avenue, Suite 835, Orange, CA 92868, USA.; University of California- Irvine Department of Family Medicine, 200 S. Manchester Avenue, Suite 835, Orange, CA 92868, USA.
AN - 42120156
BT - Prim Care
C5 - Healthcare Disparities
CP - 2
DA - Jun
DO - 10.1016/j.pop.2026.01.002
DP - NLM
ET - 20260306
IS - 2
JF - Prim Care
LA - eng
N2 - Depression is a prevalent and increasing concern in primary care, particularly among adolescents. Evidence supports routine screening, which improves remission and symptom reduction in adults and perinatal populations. Both psychotherapy and pharmacotherapy are effective first-line treatments, with similar efficacy in reducing symptoms. Selective serotonin reuptake inhibitors (SSRIs) remain the preferred outpatient antidepressant, demonstrating superiority over placebo and comparable outcomes to other agents. Generally safe for pregnant, breastfeeding, and geriatric patients, SSRIs require thoughtful selection based on side effects, contraindications, and patient preferences. Primary care clinicians are central to providing individualized, evidence-based, and patient-centered management of depression.
PY - 2026
SN - 0095-4543
SP - 153
EP - 165+
ST - Depression Updates and Selective Serotonin Reuptake Inhibitor Management
T1 - Depression Updates and Selective Serotonin Reuptake Inhibitor Management
T2 - Prim Care
TI - Depression Updates and Selective Serotonin Reuptake Inhibitor Management
U1 - Healthcare Disparities
U3 - 10.1016/j.pop.2026.01.002
VL - 53
VO - 0095-4543
Y1 - 2026
ER -