TY - JOUR
AU - A. Patel
AU - C. Wright
AU - F. Coyne
AU - R. J. Klein
AU - M. J. Nguemeni Tiako
AU - A. A. Kuo
AU - R. M. Cronin
A1 - 
AB - Adults with sickle cell disease (SCD) are living longer due to advances in care but face a growing burden of chronic comorbid conditions that fall within the scope of primary care. However, primary care providers often lack structured guidance because literature on managing these conditions in the context of SCD is limited. This article outlines clinical approaches to hypertension, diabetes, obesity, chronic constipation, reproductive health, cognitive impairments, depression, and anxiety in people living with SCD. The authors highlight relevant epidemiology, screening recommendations, and treatment considerations that differ from those in the general population. Primary care providers play a crucial role in delivering comprehensive and preventive care to people living with SCD. Specific management of common chronic conditions in this population is necessary to reduce morbidity and improve quality of life.
AD - Division of Medicine-Pediatrics and Preventive Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California (A.P., A.A.K.).; Departments of Medicine and Pediatrics, Christiana Care Health System, Wilmington, Delaware (C.W.).; Division of Transitional Care Medicine, Departments of Medicine and Pediatrics, University of Rochester Medical Center, Rochester, New York (F.C.).; Department of Medicine-Hematology/Oncology and Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama (R.J.K.).; Division of General Internal Medicine and Health Services Research, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California (M.J.N.T.).; Department of Internal Medicine, The Ohio State University, Columbus, Ohio (R.M.C.).
AN - 41730212
BT - Ann Intern Med
C5 - Healthcare Disparities
CP - 3
DA - Mar
DO - 10.7326/annals-25-04647
DP - NLM
ET - 20260224
IS - 3
JF - Ann Intern Med
LA - eng
N2 - Adults with sickle cell disease (SCD) are living longer due to advances in care but face a growing burden of chronic comorbid conditions that fall within the scope of primary care. However, primary care providers often lack structured guidance because literature on managing these conditions in the context of SCD is limited. This article outlines clinical approaches to hypertension, diabetes, obesity, chronic constipation, reproductive health, cognitive impairments, depression, and anxiety in people living with SCD. The authors highlight relevant epidemiology, screening recommendations, and treatment considerations that differ from those in the general population. Primary care providers play a crucial role in delivering comprehensive and preventive care to people living with SCD. Specific management of common chronic conditions in this population is necessary to reduce morbidity and improve quality of life.
PY - 2026
SN - 0003-4819
SP - 394
EP - 401+
ST - Addressing Primary Care Needs in People Living With Sickle Cell Disease : A Narrative Review
T1 - Addressing Primary Care Needs in People Living With Sickle Cell Disease : A Narrative Review
T2 - Ann Intern Med
TI - Addressing Primary Care Needs in People Living With Sickle Cell Disease : A Narrative Review
U1 - Healthcare Disparities
U3 - 10.7326/annals-25-04647
VL - 179
VO - 0003-4819
Y1 - 2026
ER -