TY - JOUR AU - L. Sperling AU - V. Irazola AU - J. Partarrieu AU - L. Raspail AU - M. Banach AU - A. Banerjee AU - G. Bukhman AU - M. George AU - Toda Kato AU - F. Lopez-Jimenez AU - S. Macari AU - J. Miranda AU - A. Mocumbi AU - P. Perel AU - D. Prabhakaran AU - Puente Barragan AU - D. Sherifali AU - R. Santos A1 - AB - Cardiovascular disease (CVD) commonly coexists with multiple long-term conditions (MLTC), including diabetes, chronic kidney disease, obesity, and mental health disorders. This clustering creates a syndemic burden associated with poorer outcomes, polypharmacy, high treatment burden, and rising healthcare costs. Fragmented, single-disease care models are ill-suited to address this complexity. The WHF roadmap for integrated care in people living with - or at risk of - CVD and MLTC provides a structured framework to support the design, implementation, and scale-up of person-centred, coordinated care models globally. Drawing on current evidence, expert consensus, case studies, and stakeholder surveys, the Roadmap outlines the epidemiological and systemic challenges of MLTC and identifies practical strategies adaptable across high-, middle-, and low-income settings. This Roadmap emphasises multidisciplinary teamwork, aligned financing, digital health infrastructure, workforce development, patient partnership, and robust monitoring and evaluation. By shifting from siloed care to integrated, capacity-sensitive approaches, health systems can improve clinical outcomes, enhance quality of life, reduce avoidable hospitalisations, and build resilience in the face of growing multimorbidity. AD - Emory School of Medicine, Emory Clinic, Atlanta, USA.; Institute for Clinical Effectiveness and Health Policy, Buenos Aires (IECS), Argentina.; Independent Consultant, France.; WHF, Switzerland.; Medical University in Lodz (MUL), Lodz, Poland.; University College London, UCL Hospitals NHS Trust and Barts Health NHS Trust, UK.; Harvard University, USA.; INOCA International, UK.; Kyoto University Hospital, Japan.; Mayo Clinic, USA.; Avec France, France.; University of Sydney, Australia.; Mozambique Institute for Health Education and Research, Mozambique.; McMaster University, Canada.; National Medical Center "20 de Noviembre" ISSSTE, Mexico.; Heart Institute (InCor)/University of São Paulo (USP) Medical School, Brazil. AN - 41908167 BT - Glob Heart C5 - Healthcare Disparities CP - 1 DO - 10.5334/gh.1541 DP - NLM ET - 20260327 IS - 1 JF - Glob Heart LA - eng N2 - Cardiovascular disease (CVD) commonly coexists with multiple long-term conditions (MLTC), including diabetes, chronic kidney disease, obesity, and mental health disorders. This clustering creates a syndemic burden associated with poorer outcomes, polypharmacy, high treatment burden, and rising healthcare costs. Fragmented, single-disease care models are ill-suited to address this complexity. The WHF roadmap for integrated care in people living with - or at risk of - CVD and MLTC provides a structured framework to support the design, implementation, and scale-up of person-centred, coordinated care models globally. Drawing on current evidence, expert consensus, case studies, and stakeholder surveys, the Roadmap outlines the epidemiological and systemic challenges of MLTC and identifies practical strategies adaptable across high-, middle-, and low-income settings. This Roadmap emphasises multidisciplinary teamwork, aligned financing, digital health infrastructure, workforce development, patient partnership, and robust monitoring and evaluation. By shifting from siloed care to integrated, capacity-sensitive approaches, health systems can improve clinical outcomes, enhance quality of life, reduce avoidable hospitalisations, and build resilience in the face of growing multimorbidity. PY - 2026 SN - 2211-8160 (Print); 2211-8160 SP - 28 ST - WHF Roadmap for Integrated Care in People Living with - or at Risk of - Cardiovascular Disease and Multiple Long-Term Conditions T1 - WHF Roadmap for Integrated Care in People Living with - or at Risk of - Cardiovascular Disease and Multiple Long-Term Conditions T2 - Glob Heart TI - WHF Roadmap for Integrated Care in People Living with - or at Risk of - Cardiovascular Disease and Multiple Long-Term Conditions U1 - Healthcare Disparities U3 - 10.5334/gh.1541 VL - 21 VO - 2211-8160 (Print); 2211-8160 Y1 - 2026 ER -