TY - JOUR AU - N. Howlett AU - V. Antonopoulou AU - A. McKinlay AU - F. Lorencatto AU - L. J. McGowan AU - D. Osborn AU - A. O'Donnell AU - E. J. Oliver AU - I. Vlaev AU - F. F. Sniehotta AU - M. P. Kelly AU - S. Michie AU - C. Kemp AU - Y. Pappas AU - G. Randhawa AU - N. Ali AU - E. Munro AU - A. M. Chater A1 - AB - BACKGROUND: Cardiovascular disease (CVD) risk factors and mild-to-moderate mental health concerns (anxiety, depression) often co-occur and can worsen individual health outcomes, increase healthcare burden, and related costs relative to non-co/multi-morbidity. Existing evidence from both staff and service users suggests that integrating care for this population can be beneficial but challenging. Therefore, it is important that the key influences on integrated care are mapped to behavioural science frameworks so that intervention strategies in the system are actionable. This review aims to synthesise findings on which individual, organisational, social, and system-level factors influence integrated care for people experiencing co-occurring CVD risk factors and mild-to-moderate mental health concerns from the perspective of a range of health and social care professionals. METHODS: This systematic review will search MEDLINE, Embase, Emcare, PsycInfo, CINAHL, and grey literature in PsyArXiv and HMIC. Included studies will be qualitative primary research published in the English language reporting on the factors that influence the commissioning and implementation of integrated care for adults at risk of CVD and experiencing mild-to-moderate mental health concerns. This will be from the perspective of healthcare professionals, managers, commissioners, and policymakers. A thematic synthesis will identify relevant actions, actors, context, targets, and timeframes using the AACTT framework, and influences on actors' behaviour will be mapped to the Consolidated Framework for Implementation Research (CFIR) and the Theoretical Domains Framework (TDF). DISCUSSION: Data from this review will provide insight for a larger NHIR-funded programme of work that aims to optimise Integrated Care Services (OptICS) that will develop a whole-systems map to identify appropriate targets and intervention strategies to optimise integrated care. This review will offer a novel contribution to knowledge by synthesising qualitative evidence from a range of stakeholders on the influences on commissioning and implementation of integrated care for adults with physical and mental health comorbidities, mapped to complementary implementation frameworks. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42024554221. AD - NIHR Policy Research Unit (PRU) in Behavioural and Social Sciences, Centre for Behaviour Change (CBC), Department of Clinical, Educational and Health Psychology, University College London, 1-19 Torrington Place, London, WC1E 7HB, UK.; Department of Psychology, Sport, and Geography, University of Hertfordshire, College Lane Campus, College Lane, Hatfield, AL10 9AB, UK.; NIHR Policy Research Unit (PRU) in Behavioural and Social Sciences, Centre for Behaviour Change (CBC), Department of Clinical, Educational and Health Psychology, University College London, 1-19 Torrington Place, London, WC1E 7HB, UK. v.antonopoulou@ucl.ac.uk.; NIHR Policy Research Unit in Behavioural and Social Sciences, Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK.; Centre for Behavioral and Implementation Science Interventions (BISI), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Department of Public Health and Primary Care and Cambridge Public Health, University of Cambridge, Cambridge, UK.; NIHR Policy Research Unit in Behavioural and Social Sciences, Centre for Health, Wellbeing and Behaviour Change, University of Bedfordshire, Polhill Avenue, Bedford, MK419EA, UK. AN - 41239460 BT - Syst Rev C5 - Healthcare Disparities CP - 1 DA - Nov 14 DO - 10.1186/s13643-025-02970-5 DP - NLM ET - 20251114 IS - 1 JF - Syst Rev LA - eng N2 - BACKGROUND: Cardiovascular disease (CVD) risk factors and mild-to-moderate mental health concerns (anxiety, depression) often co-occur and can worsen individual health outcomes, increase healthcare burden, and related costs relative to non-co/multi-morbidity. Existing evidence from both staff and service users suggests that integrating care for this population can be beneficial but challenging. Therefore, it is important that the key influences on integrated care are mapped to behavioural science frameworks so that intervention strategies in the system are actionable. This review aims to synthesise findings on which individual, organisational, social, and system-level factors influence integrated care for people experiencing co-occurring CVD risk factors and mild-to-moderate mental health concerns from the perspective of a range of health and social care professionals. METHODS: This systematic review will search MEDLINE, Embase, Emcare, PsycInfo, CINAHL, and grey literature in PsyArXiv and HMIC. Included studies will be qualitative primary research published in the English language reporting on the factors that influence the commissioning and implementation of integrated care for adults at risk of CVD and experiencing mild-to-moderate mental health concerns. This will be from the perspective of healthcare professionals, managers, commissioners, and policymakers. A thematic synthesis will identify relevant actions, actors, context, targets, and timeframes using the AACTT framework, and influences on actors' behaviour will be mapped to the Consolidated Framework for Implementation Research (CFIR) and the Theoretical Domains Framework (TDF). DISCUSSION: Data from this review will provide insight for a larger NHIR-funded programme of work that aims to optimise Integrated Care Services (OptICS) that will develop a whole-systems map to identify appropriate targets and intervention strategies to optimise integrated care. This review will offer a novel contribution to knowledge by synthesising qualitative evidence from a range of stakeholders on the influences on commissioning and implementation of integrated care for adults with physical and mental health comorbidities, mapped to complementary implementation frameworks. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42024554221. PY - 2025 SN - 2046-4053 SP - 224 ST - Factors that influence the commissioning and implementation of integrated care for adults at risk of cardiovascular disease and mild-to-moderate mental health concerns in the UK: a systematic review protocol T1 - Factors that influence the commissioning and implementation of integrated care for adults at risk of cardiovascular disease and mild-to-moderate mental health concerns in the UK: a systematic review protocol T2 - Syst Rev TI - Factors that influence the commissioning and implementation of integrated care for adults at risk of cardiovascular disease and mild-to-moderate mental health concerns in the UK: a systematic review protocol U1 - Healthcare Disparities U3 - 10.1186/s13643-025-02970-5 VL - 14 VO - 2046-4053 Y1 - 2025 ER -