TY - JOUR
AU - C. Teusen
AU - A. Hapfelmeier
AU - M. Bühner
AU - P. Sterner
AU - L. Schäffler
AU - P. Beigel
AU - V. von Schrottenberg
AU - J. Gensichen
AU - K. Linde
AU - A. Schneider
A1 - 
AB - INTRODUCTION: The general practitioners' (GP) approach to diagnosing depression has not yet been included in depression questionnaires. Therefore, the 'Questionnaire for the assessment of DEpression SYmptoms in Primary Care' (DESY-PC) has been developed. The DESY-PC consists of two parts, comprising the patient's perspective and psychiatric diagnostic criteria (DESY-PAT), and additionally the GP's heuristics and knowledge of patients (DESY-GP). The aim was to investigate the diagnostic accuracy and factor structure of the DESY-PC. METHODS: A multicentre diagnostic accuracy study was conducted in ten practices. Patients completed the DESY-PAT and PHQ-9 (Patient Health Questionnaire-9), while their GPs completed the DESY-GP. The Structured Clinical Interview for DSM-V disorders (SCID-V-CV) was used as reference standard. Sensitivity, specificity, receiver operating characteristic curves (ROC) and area under the curve (AUC) values were calculated to determine the diagnostic accuracy of the DESY-PC and PHQ-9. Factorial validity was assessed. RESULTS: 435 patients (mean age 47.6 years, 60.1% female, prevalence of depression 15.9%) were analysed. The diagnostic accuracy of the DESY-PAT (AUC=0.862, 95% Confidence Interval 0.815-0.908) was significantly higher (p<0.001) than that of PHQ-9 (AUC=0.821, 0.764-0.878). The diagnostic accuracy increased further when DESY-PAT was combined with DESY-GP for the overall questionnaire DESY-PC (AUC=0.874, 0.834-0.914). Goodness of fit indices indicated a plausible fit for the DESY-PC. CONCLUSIONS: Incorporating the GP's heuristics, judgement and knowledge of the patient contributes to a more accurate diagnosis. The DESY-PC integrates the GP's perspective, patient-specific factors, and psychiatric criteria into the diagnostic assessment, which might contribute to improved diagnostic decision-making in primary care.
AD - Institute of General Practice and Health Services Research, Department of Clinical Medicine, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany. Electronic address: clara.teusen@mri.tum.de.; Institute of General Practice and Health Services Research, Department of Clinical Medicine, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany; Institute of AI and Informatics in Medicine, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany.; Department Psychology, LMU Munich, Munich, Germany.; Institute of General Practice and Health Services Research, Department of Clinical Medicine, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany.; Institute of General Practice and Family Medicine, University Hospital of the LMU Munich, Munich, Germany.
AN - 41197537
BT - Psychiatry Res
C5 - Measures
DA - Dec
DO - 10.1016/j.psychres.2025.116807
DP - NLM
ET - 20251028
JF - Psychiatry Res
LA - eng
N2 - INTRODUCTION: The general practitioners' (GP) approach to diagnosing depression has not yet been included in depression questionnaires. Therefore, the 'Questionnaire for the assessment of DEpression SYmptoms in Primary Care' (DESY-PC) has been developed. The DESY-PC consists of two parts, comprising the patient's perspective and psychiatric diagnostic criteria (DESY-PAT), and additionally the GP's heuristics and knowledge of patients (DESY-GP). The aim was to investigate the diagnostic accuracy and factor structure of the DESY-PC. METHODS: A multicentre diagnostic accuracy study was conducted in ten practices. Patients completed the DESY-PAT and PHQ-9 (Patient Health Questionnaire-9), while their GPs completed the DESY-GP. The Structured Clinical Interview for DSM-V disorders (SCID-V-CV) was used as reference standard. Sensitivity, specificity, receiver operating characteristic curves (ROC) and area under the curve (AUC) values were calculated to determine the diagnostic accuracy of the DESY-PC and PHQ-9. Factorial validity was assessed. RESULTS: 435 patients (mean age 47.6 years, 60.1% female, prevalence of depression 15.9%) were analysed. The diagnostic accuracy of the DESY-PAT (AUC=0.862, 95% Confidence Interval 0.815-0.908) was significantly higher (p<0.001) than that of PHQ-9 (AUC=0.821, 0.764-0.878). The diagnostic accuracy increased further when DESY-PAT was combined with DESY-GP for the overall questionnaire DESY-PC (AUC=0.874, 0.834-0.914). Goodness of fit indices indicated a plausible fit for the DESY-PC. CONCLUSIONS: Incorporating the GP's heuristics, judgement and knowledge of the patient contributes to a more accurate diagnosis. The DESY-PC integrates the GP's perspective, patient-specific factors, and psychiatric criteria into the diagnostic assessment, which might contribute to improved diagnostic decision-making in primary care.
PY - 2025
SN - 0165-1781
SP - 116807
ST - Diagnostic accuracy and factorial structure of the questionnaire for the assessment of depression symptoms in primary care (DESY-PC)
T1 - Diagnostic accuracy and factorial structure of the questionnaire for the assessment of depression symptoms in primary care (DESY-PC)
T2 - Psychiatry Res
TI - Diagnostic accuracy and factorial structure of the questionnaire for the assessment of depression symptoms in primary care (DESY-PC)
U1 - Measures
U3 - 10.1016/j.psychres.2025.116807
VL - 354
VO - 0165-1781
Y1 - 2025
ER -