TY - JOUR AU - A. Iyanda AU - R. Adeleke AU - O. Iyanda A1 - AB - BACKGROUND: Emergency room (ER) use reflects acute healthcare burden, but the roles of chronic health conditions (CHCs), substance use disorders (SUDs), drug use disorders (DUDs), and mental health conditions (MHCs) remain underexplored across populations. METHODS: Using nationally representative survey data (N = 226,838; weighted = 1,243,120,763), we applied survey-weighted logistic regression to examine predictors of ER visits. Covariates included CHCs, SUDs, DUDs, severity levels of these orders, MHCs, race/ethnicity, education, employment, residence, and body mass index. RESULTS: Adults with ≥ 1 CHC were more likely to visit the ER (OR = 1.72; 95 % CI: 1.60-1.85). DUD significantly increased ER use (OR = 1.70; 95 % CI: 1.54-1.88), while overall SUD was not significant after adjustment (OR = 1.05; 95 % CI: 0.98-1.12). Severe SUD elevated ER use even without CHCs (OR = 1.89; 95 % CI: 1.67-2.13). African Americans had higher odds of ER visits (OR = 1.28; 95 % CI: 1.21-1.36), and Native American/Alaska Natives were more likely to report DUD (OR = 1.55; 95 % CI: 1.31-1.82). Lower educational attainment (OR = 1.22; 95 % CI: 1.16-1.28) and unemployment (OR = 1.34; 95 % CI: 1.25-1.43) were linked to higher risks. MHCs predicted ER use (OR = 1.63; 95 % CI: 1.53-1.74) and substance-related disorders. CONCLUSIONS: CHCs, DUD severity, and MHCs are strong predictors of ER utilization. Disparities among African Americans and Native American/Alaska Natives highlight the need for integrated care addressing chronic illness, behavioral health, and substance use-particularly for socioeconomically and racially marginalized groups. AD - Division of Social Work, Prairie View A&M University, Texas, USA.; Department of Geography and Environmental Management, University of Waterloo, Waterloo, Canada.; Department of Social Work, Prairie View A&M University, Texas, USA. AN - 41312192 BT - Addict Behav Rep C5 - Opioids & Substance Use DA - Dec DO - 10.1016/j.abrep.2025.100639 DP - NLM ET - 20251101 JF - Addict Behav Rep LA - eng N2 - BACKGROUND: Emergency room (ER) use reflects acute healthcare burden, but the roles of chronic health conditions (CHCs), substance use disorders (SUDs), drug use disorders (DUDs), and mental health conditions (MHCs) remain underexplored across populations. METHODS: Using nationally representative survey data (N = 226,838; weighted = 1,243,120,763), we applied survey-weighted logistic regression to examine predictors of ER visits. Covariates included CHCs, SUDs, DUDs, severity levels of these orders, MHCs, race/ethnicity, education, employment, residence, and body mass index. RESULTS: Adults with ≥ 1 CHC were more likely to visit the ER (OR = 1.72; 95 % CI: 1.60-1.85). DUD significantly increased ER use (OR = 1.70; 95 % CI: 1.54-1.88), while overall SUD was not significant after adjustment (OR = 1.05; 95 % CI: 0.98-1.12). Severe SUD elevated ER use even without CHCs (OR = 1.89; 95 % CI: 1.67-2.13). African Americans had higher odds of ER visits (OR = 1.28; 95 % CI: 1.21-1.36), and Native American/Alaska Natives were more likely to report DUD (OR = 1.55; 95 % CI: 1.31-1.82). Lower educational attainment (OR = 1.22; 95 % CI: 1.16-1.28) and unemployment (OR = 1.34; 95 % CI: 1.25-1.43) were linked to higher risks. MHCs predicted ER use (OR = 1.63; 95 % CI: 1.53-1.74) and substance-related disorders. CONCLUSIONS: CHCs, DUD severity, and MHCs are strong predictors of ER utilization. Disparities among African Americans and Native American/Alaska Natives highlight the need for integrated care addressing chronic illness, behavioral health, and substance use-particularly for socioeconomically and racially marginalized groups. PY - 2025 SN - 2352-8532 SP - 100639 ST - Compounding risks of chronic health conditions and substance use disorder on healthcare burden in the USA: Analysis of NSDUH data (2021-2023) T1 - Compounding risks of chronic health conditions and substance use disorder on healthcare burden in the USA: Analysis of NSDUH data (2021-2023) T2 - Addict Behav Rep TI - Compounding risks of chronic health conditions and substance use disorder on healthcare burden in the USA: Analysis of NSDUH data (2021-2023) U1 - Opioids & Substance Use U3 - 10.1016/j.abrep.2025.100639 VL - 22 VO - 2352-8532 Y1 - 2025 ER -