TY - JOUR AU - A. Brown AU - S. M. Kelly AU - T. Agee AU - J. Hsu AU - N. Schweizer AU - G. Chander AU - L. W. Chang AU - S. Schwartz AU - O. Falade-Nwulia A1 - AB - BACKGROUND: Integration of substance use disorder (SUD) care into infectious disease care settings has potential to address high rates of SUD among people with infectious diseases. An understanding of patient perspectives is crucial to optimizing care integration models. METHODS: RESTORE is a low-threshold infectious disease/SUD care integration model incorporating clinician training and support for SUD care provision and peer support for patient engagement implemented in an outpatient infectious disease clinic in Baltimore, Maryland. Guided by the Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) framework, in-depth interviews were completed with participants currently engaged (n = 10) and disengaged (n = 10) from RESTORE. Using a grounded theory approach, themes were synthesized to evaluate reach, effectiveness, maintenance, acceptability, and appropriateness of RESTORE from patients' perspectives. RESULTS: RESTORE participants described a range of experiences and barriers to engaging in SUD treatment prior to RESTORE. Participants' perceptions of effectiveness with RESTORE included observed changes in substance use, mental health, and overall quality of life for many, but not all. Sustained impact of RESTORE engagement on participant outcomes also varied. Acceptability and appropriateness of integrated infectious disease and SUD treatment, RESTORE team care coordination, and peer coaching for self-efficacy in SUD recovery were key mechanisms perceived to impact effectiveness. CONCLUSION: A peer-facilitated integrated infectious disease/SUD care model was regarded as acceptable, appropriate, and effective in improving outcomes for patients with SUD accessing infectious disease care. Additional strategies are needed to optimize outcomes across the spectrum of patients with infectious disease and SUD. AD - Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, USA. Electronic address: abrow272@jh.edu.; Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, USA.; Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, USA.; Department of General Internal Medicine, University of Washington, Washington, USA.; Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, USA. AN - 40570718 BT - Int J Drug Policy C5 - Opioids & Substance Use DA - Sep DO - 10.1016/j.drugpo.2025.104883 DP - NLM ET - 20250625 JF - Int J Drug Policy LA - eng N2 - BACKGROUND: Integration of substance use disorder (SUD) care into infectious disease care settings has potential to address high rates of SUD among people with infectious diseases. An understanding of patient perspectives is crucial to optimizing care integration models. METHODS: RESTORE is a low-threshold infectious disease/SUD care integration model incorporating clinician training and support for SUD care provision and peer support for patient engagement implemented in an outpatient infectious disease clinic in Baltimore, Maryland. Guided by the Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) framework, in-depth interviews were completed with participants currently engaged (n = 10) and disengaged (n = 10) from RESTORE. Using a grounded theory approach, themes were synthesized to evaluate reach, effectiveness, maintenance, acceptability, and appropriateness of RESTORE from patients' perspectives. RESULTS: RESTORE participants described a range of experiences and barriers to engaging in SUD treatment prior to RESTORE. Participants' perceptions of effectiveness with RESTORE included observed changes in substance use, mental health, and overall quality of life for many, but not all. Sustained impact of RESTORE engagement on participant outcomes also varied. Acceptability and appropriateness of integrated infectious disease and SUD treatment, RESTORE team care coordination, and peer coaching for self-efficacy in SUD recovery were key mechanisms perceived to impact effectiveness. CONCLUSION: A peer-facilitated integrated infectious disease/SUD care model was regarded as acceptable, appropriate, and effective in improving outcomes for patients with SUD accessing infectious disease care. Additional strategies are needed to optimize outcomes across the spectrum of patients with infectious disease and SUD. PY - 2025 SN - 0955-3959 SP - 104883 ST - "It makes all the sense in the world": A qualitative evaluation of patient perspectives on implementation outcomes of a peer-facilitated integrated infectious disease and substance use care model T1 - "It makes all the sense in the world": A qualitative evaluation of patient perspectives on implementation outcomes of a peer-facilitated integrated infectious disease and substance use care model T2 - Int J Drug Policy TI - "It makes all the sense in the world": A qualitative evaluation of patient perspectives on implementation outcomes of a peer-facilitated integrated infectious disease and substance use care model U1 - Opioids & Substance Use U3 - 10.1016/j.drugpo.2025.104883 VL - 143 VO - 0955-3959 Y1 - 2025 ER -