TY - JOUR KW - Aged KW - Aged, 80 and over KW - Anxiety Disorders/economics/prevention & control KW - Community Mental Health Services/economics/methods KW - Cost-Benefit Analysis KW - Depressive Disorder/economics/prevention & control KW - Female KW - Health Care Costs/statistics & numerical data KW - Humans KW - Male KW - Netherlands KW - Patient Acceptance of Health Care KW - Primary Health Care/economics/methods KW - Psychiatric Status Rating Scales KW - Sensitivity and Specificity KW - Treatment Outcome AU - Van't Veer-Tazelaar AU - F. Smit AU - H. van Hout AU - P. van Oppen AU - H. van der Horst AU - A. Beekman AU - H. van Marwijk A1 - AB - BACKGROUND: There is an urgent need for the development of cost-effective preventive strategies to reduce the onset of mental disorders. AIMS: To establish the cost-effectiveness of a stepped care preventive intervention for depression and anxiety disorders in older people at high risk of these conditions, compared with routine primary care. METHOD: An economic evaluation was conducted alongside a pragmatic randomised controlled trial (ISRCTN26474556). Consenting individuals presenting with subthreshold levels of depressive or anxiety symptoms were randomly assigned to a preventive stepped care programme (n = 86) or to routine primary care (n = 84). RESULTS: The intervention was successful in halving the incidence rate of depression and anxiety at euro563 ( pound412) per recipient and euro4367 ( pound3196) per disorder-free year gained, compared with routine primary care. The latter would represent good value for money if the willingness to pay for a disorder-free year is at least euro5000. CONCLUSIONS: The prevention programme generated depression- and anxiety-free survival years in the older population at affordable cost. BT - The British journal of psychiatry : the journal of mental science C5 - Financing & Sustainability CY - England DO - 10.1192/bjp.bp.109.069617 JF - The British journal of psychiatry : the journal of mental science N2 - BACKGROUND: There is an urgent need for the development of cost-effective preventive strategies to reduce the onset of mental disorders. AIMS: To establish the cost-effectiveness of a stepped care preventive intervention for depression and anxiety disorders in older people at high risk of these conditions, compared with routine primary care. METHOD: An economic evaluation was conducted alongside a pragmatic randomised controlled trial (ISRCTN26474556). Consenting individuals presenting with subthreshold levels of depressive or anxiety symptoms were randomly assigned to a preventive stepped care programme (n = 86) or to routine primary care (n = 84). RESULTS: The intervention was successful in halving the incidence rate of depression and anxiety at euro563 ( pound412) per recipient and euro4367 ( pound3196) per disorder-free year gained, compared with routine primary care. The latter would represent good value for money if the willingness to pay for a disorder-free year is at least euro5000. CONCLUSIONS: The prevention programme generated depression- and anxiety-free survival years in the older population at affordable cost. PP - England PY - 2010 SN - 1472-1465; 0007-1250 SP - 319 EP - 325 EP - T1 - Cost-effectiveness of a stepped care intervention to prevent depression and anxiety in late life: Randomised trial T2 - The British journal of psychiatry : the journal of mental science TI - Cost-effectiveness of a stepped care intervention to prevent depression and anxiety in late life: Randomised trial U1 - Financing & Sustainability U2 - 20357310 U3 - 10.1192/bjp.bp.109.069617 VL - 196 VO - 1472-1465; 0007-1250 Y1 - 2010 ER -