TY - JOUR
AU - V. Mammarella
AU - M. Breda
AU - D. Esposito
AU - S. Orecchio
AU - D. Polese
AU - O. Bruni
A1 - 
AB - Recent research reported an association between pediatric Restless Leg Syndrome (RLS) and psychiatric disorders, in particular attention-deficit hyperactivity disorder in which shared symptoms, such as restlessness and difficulty concentrating, can make differential diagnosis challenging. Comorbidities with depression and anxiety, present in adults, have to be considered in children. Behavioral and psychosomatic disorders and autism can be associated with RLS. Both neurobiologic mechanisms and clinical implication could explain the several comorbidities. In clinical practice, pediatric RLS patients should be evaluated for the presence of psychiatric disorders to tailor multidisciplinary intervention and integrated treatment.
AD - Department of Psychology, Sapienza University of Rome, Via dei Marsi 78, Rome 00185.; Independent.; Department of Neuroscience, Mental Health and Sensory Organs NESMOS, Sapienza University of Rome, Sant'Andrea Hospital, Via di Grottarossa 1035-1039, Rome 00189, Italy.; Department Developmental and Social Psychology, Sapienza University of Rome, Via dei Marsi 78, Rome 00185, Italy. Electronic address: oliviero.bruni@uniroma1.it.
AN - 40348533
BT - Sleep Med Clin
C5 - Medically Unexplained Symptoms
CP - 2
DA - Jun
DO - 10.1016/j.jsmc.2025.02.004
DP - NLM
ET - 20250311
IS - 2
JF - Sleep Med Clin
LA - eng
N2 - Recent research reported an association between pediatric Restless Leg Syndrome (RLS) and psychiatric disorders, in particular attention-deficit hyperactivity disorder in which shared symptoms, such as restlessness and difficulty concentrating, can make differential diagnosis challenging. Comorbidities with depression and anxiety, present in adults, have to be considered in children. Behavioral and psychosomatic disorders and autism can be associated with RLS. Both neurobiologic mechanisms and clinical implication could explain the several comorbidities. In clinical practice, pediatric RLS patients should be evaluated for the presence of psychiatric disorders to tailor multidisciplinary intervention and integrated treatment.
PY - 2025
SN - 1556-407x
SP - 209
EP - 218+
ST - Psychiatric Comorbidities in Pediatric Restless Leg Syndrome
T1 - Psychiatric Comorbidities in Pediatric Restless Leg Syndrome
T2 - Sleep Med Clin
TI - Psychiatric Comorbidities in Pediatric Restless Leg Syndrome
U1 - Medically Unexplained Symptoms
U3 - 10.1016/j.jsmc.2025.02.004
VL - 20
VO - 1556-407x
Y1 - 2025
ER -