TY - JOUR
AU - C. A. Austin
AU - B. Seligman
AU - S. Shan-Bala
AU - G. A. Kuchel
AU - K. P. Loh
AU - C. E. Kistler
AU - J. A. Batsis
A1 - 
AB - Precision medicine presents an opportunity to use novel, data-driven strategies to improve patient care. The field of precision medicine has undergone many advancements over the past few years. It has moved beyond incorporation of individualized genetic risk into medical decision-making to include multiple other factors such as unique social, demographic, behavioral, and clinical characteristics. Geriatric medicine stands to benefit heavily from the integration of precision medicine into its standard practices. Older adults, compared with other populations, have high clinical and biological heterogeneity that can alter the risks and benefits of different approaches to patient care. These factors have not been routinely considered previously by geriatricians. Yet, geriatricians' ability to address older adults' baseline heterogeneity is increasingly recognized as a cornerstone of delivering quality care in a geriatric medical practice. Given the shared focus of individualized decision-making, precision medicine is a natural fit for geriatric medicine. This manuscript provides, via cases and discussion, examples that illustrate how precision medicine can improve the care of our older patients today. We will share specific and existing tools and evidence, and review the existing multilevel barriers to further incorporate and implement these tools into clinical practice. We propose methods to address these barriers and to help realize the full potential of precision medicine for the care of older adults. We conclude with a brief discussion of potential future directions of research of precision medicine in the care of older adults.
AD - Division of Pulmonary and Critical Care Medicine, University of North Carolina, Chapel Hill, North Carolina, USA.; Division of Geriatric Medicine and Center for Aging and Health, University of North Carolina, Chapel Hill, North Carolina, USA.; Geriatric Research, Education and Clinical Center, VA Greater Los Angeles Health Care System, Los Angeles, California, USA.; Division of Geriatric Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA.; Division of Geriatric Medicine, Department of Medicine, Inova Health System, Fairfax Medical Campus, Falls Church, Virginia, USA.; UConn Center on Aging, University of Connecticut School of Medicine, Farmington, Connecticut, USA.; Division of Hematology/Oncology, Department of Medicine, James P. Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, New York, USA.; Division of Geriatric Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Department of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA.
AN - 38888213
BT - J Am Geriatr Soc
C5 - Healthcare Disparities
CP - 10
DA - Oct
DO - 10.1111/jgs.19036
DP - NLM
ET - 20240618
IS - 10
JF - J Am Geriatr Soc
LA - eng
N2 - Precision medicine presents an opportunity to use novel, data-driven strategies to improve patient care. The field of precision medicine has undergone many advancements over the past few years. It has moved beyond incorporation of individualized genetic risk into medical decision-making to include multiple other factors such as unique social, demographic, behavioral, and clinical characteristics. Geriatric medicine stands to benefit heavily from the integration of precision medicine into its standard practices. Older adults, compared with other populations, have high clinical and biological heterogeneity that can alter the risks and benefits of different approaches to patient care. These factors have not been routinely considered previously by geriatricians. Yet, geriatricians' ability to address older adults' baseline heterogeneity is increasingly recognized as a cornerstone of delivering quality care in a geriatric medical practice. Given the shared focus of individualized decision-making, precision medicine is a natural fit for geriatric medicine. This manuscript provides, via cases and discussion, examples that illustrate how precision medicine can improve the care of our older patients today. We will share specific and existing tools and evidence, and review the existing multilevel barriers to further incorporate and implement these tools into clinical practice. We propose methods to address these barriers and to help realize the full potential of precision medicine for the care of older adults. We conclude with a brief discussion of potential future directions of research of precision medicine in the care of older adults.
PY - 2024
SN - 0002-8614 (Print); 0002-8614
SP - 2972
EP - 2980+
ST - Aging precisely: Precision medicine through the lens of an older adult
T1 - Aging precisely: Precision medicine through the lens of an older adult
T2 - J Am Geriatr Soc
TI - Aging precisely: Precision medicine through the lens of an older adult
U1 - Healthcare Disparities
U3 - 10.1111/jgs.19036
VL - 72
VO - 0002-8614 (Print); 0002-8614
Y1 - 2024
ER -