TY - JOUR
AU - K. S. Ryan
AU - K. C. Prewitt
AU - S. Hayer
AU - M. A. Hedges
AU - A. E. Benson
AU - J. O. Lo
A1 - 
AB - IMPORTANCE: The use and misuse of opioids in pregnancy have been increasing and are a major public health issue. Opioid use in pregnancy and during lactation has been associated with increased maternal and neonatal morbidity and mortality. OBJECTIVE: This review aims to summarize the existing literature and current recommendations for opioid use while pregnant or lactating. EVIDENCE ACQUISITION: A PubMed, Cochrane Library, and Google Scholar literature search using the following terms was performed to gather relevant data: "opioids," "opioid maintenance therapy," "opioid use disorder," "suboxone," "buprenorphine," "methadone," "medication for opioid use disorder," "fetal outcomes," "perinatal outcomes," "pregnancy," "lactation," and "neonatal abstinence syndrome." RESULTS: Available studies on opioid use in pregnancy and during lactation were reviewed and support association with increased odds of maternal death, placental insufficiency, cardiac arrest, preterm birth, neonatal intensive care unit admission, low birth weight, and small for gestational age infants. Studies were also reviewed on pharmacotherapy options in pregnancy and promising prenatal care models. CONCLUSION AND RELEVANCE: There is a critical need for research on the effects of opioid use and related pharmacotherapy options in pregnancy. Once the adverse perinatal effects of opioid exposure are identified and well-characterized, patient education, intervention, and antenatal surveillance can be developed to predict and mitigate its impact on maternal and fetal health.
AD - PGY5, Maternal Fetal Medicine Fellow.; PGY4, OBGYN Resident.; PGY2, OBGYN Resident.; Research Assistant.; Assistant Professor.; Associate Professor, Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR.
AN - 36607200
BT - Obstet Gynecol Surv
C5 - Opioids & Substance Use; Healthcare Disparities
CP - 1
DA - Jan
DO - 10.1097/ogx.0000000000001094
DP - NLM
IS - 1
JF - Obstet Gynecol Surv
LA - eng
N2 - IMPORTANCE: The use and misuse of opioids in pregnancy have been increasing and are a major public health issue. Opioid use in pregnancy and during lactation has been associated with increased maternal and neonatal morbidity and mortality. OBJECTIVE: This review aims to summarize the existing literature and current recommendations for opioid use while pregnant or lactating. EVIDENCE ACQUISITION: A PubMed, Cochrane Library, and Google Scholar literature search using the following terms was performed to gather relevant data: "opioids," "opioid maintenance therapy," "opioid use disorder," "suboxone," "buprenorphine," "methadone," "medication for opioid use disorder," "fetal outcomes," "perinatal outcomes," "pregnancy," "lactation," and "neonatal abstinence syndrome." RESULTS: Available studies on opioid use in pregnancy and during lactation were reviewed and support association with increased odds of maternal death, placental insufficiency, cardiac arrest, preterm birth, neonatal intensive care unit admission, low birth weight, and small for gestational age infants. Studies were also reviewed on pharmacotherapy options in pregnancy and promising prenatal care models. CONCLUSION AND RELEVANCE: There is a critical need for research on the effects of opioid use and related pharmacotherapy options in pregnancy. Once the adverse perinatal effects of opioid exposure are identified and well-characterized, patient education, intervention, and antenatal surveillance can be developed to predict and mitigate its impact on maternal and fetal health.
PY - 2023
SN - 0029-7828
SP - 35
EP - 49+
ST - Opioid Use in Pregnancy: A Review
T1 - Opioid Use in Pregnancy: A Review
T2 - Obstet Gynecol Surv
TI - Opioid Use in Pregnancy: A Review
U1 - Opioids & Substance Use; Healthcare Disparities
U3 - 10.1097/ogx.0000000000001094
VL - 78
VO - 0029-7828
Y1 - 2023
ER -