TY - JOUR AU - C. Allen AU - C. Arredondo AU - R. Dunham AU - M. Fishman AU - L. Lev AU - S. Mace AU - J. Parks AU - D. Rosa AU - S. Shoyinka AU - D. White AU - A. Williams A1 - AB - The use of fentanyl and its analogs is the primary driver of deaths related to the opioid overdose crisis. In fall 2021, the U.S. Drug Enforcement Administration issued its first public safety alert in 6 years to raise awareness of the escalating prevalence of fentanyl in counterfeit pills and in other opioids, such as heroin, and nonopioids, such as methamphetamine. In addition to increased public awareness, specific actions are needed to remediate the risk for fentanyl overdose. The authors endorse four principles to address the opioid overdose crisis and provide guidance for remediating its impacts: an incremental approach to behavior change or harm reduction; engagement strategies for individuals with substance use disorder; an integrated care approach to ensure better access to treatment programs and effective interventions; and vigilance among clinicians, program staff, and patients to the threat of fentanyl-adulterated drugs. The authors offer specific recommendations on how to apply these principles effectively within health care systems, communities, and law enforcement agencies across the United States. AD - Addiction Services, Hartford HealthCare, Meriden, Connecticut (Allen); El Rio Community Health Center, Tucson (Arredondo); Metropolitan Human Services District, New Orleans (Dunham); Maryland Treatment Centers, Johns Hopkins University, Baltimore (Fishman); Beebe Healthcare, Lewes, Delaware (Lev); National Council for Mental Wellbeing, Washington, D.C. (Mace, Parks, Williams); Emergency Medicine, Acacia Network, New York City (Rosa); Department of Behavioral Health and Intellectual Disability Services, Philadelphia (Shoyinka); Psychiatric Emergency Services, Grady Health System, Emory University School of Medicine, Atlanta (White). AN - 37042103 BT - Psychiatr Serv C5 - Opioids & Substance Use; Education & Workforce CP - 10 DA - Oct 1 DO - 10.1176/appi.ps.202100660 DP - NLM ET - 20230412 IS - 10 JF - Psychiatr Serv LA - eng N2 - The use of fentanyl and its analogs is the primary driver of deaths related to the opioid overdose crisis. In fall 2021, the U.S. Drug Enforcement Administration issued its first public safety alert in 6 years to raise awareness of the escalating prevalence of fentanyl in counterfeit pills and in other opioids, such as heroin, and nonopioids, such as methamphetamine. In addition to increased public awareness, specific actions are needed to remediate the risk for fentanyl overdose. The authors endorse four principles to address the opioid overdose crisis and provide guidance for remediating its impacts: an incremental approach to behavior change or harm reduction; engagement strategies for individuals with substance use disorder; an integrated care approach to ensure better access to treatment programs and effective interventions; and vigilance among clinicians, program staff, and patients to the threat of fentanyl-adulterated drugs. The authors offer specific recommendations on how to apply these principles effectively within health care systems, communities, and law enforcement agencies across the United States. PY - 2023 SN - 1075-2730 SP - 1059 EP - 1062+ ST - Guidance for Handling the Increasing Prevalence of Drugs Adulterated or Laced With Fentanyl T1 - Guidance for Handling the Increasing Prevalence of Drugs Adulterated or Laced With Fentanyl T2 - Psychiatr Serv TI - Guidance for Handling the Increasing Prevalence of Drugs Adulterated or Laced With Fentanyl U1 - Opioids & Substance Use; Education & Workforce U3 - 10.1176/appi.ps.202100660 VL - 74 VO - 1075-2730 Y1 - 2023 ER -