TY - JOUR
KW - Administration, Intranasal
KW - Adult
KW - Allied Health Personnel
KW - Drug Overdose/diagnosis/drug therapy/epidemiology
KW - Emergency Medical Services
KW - Epidemics
KW - Female
KW - Humans
KW - Incidence
KW - Male
KW - Naloxone/administration & dosage
KW - Narcotic Antagonists/administration & dosage
KW - Opioid-Related Disorders/epidemiology
KW - Police
KW - Retrospective Studies
KW - Young Adult
KW - EMS
KW - naloxone
KW - Fentanyl
KW - Heroin
KW - Overdose
KW - prehospital
AU - Ronald Klebacher
AU - Matthew I. Harris
AU - Navin Ariyaprakai
AU - Ammundeep Tagore
AU - Vince Robbins
AU - Larissa Sophia Dudley
AU - Robert Bauter
AU - Susmith Koneru
AU - Ryan D. Hill
AU - Eric Wasserman
AU - Andrew Shanes
AU - Mark A. Merlin
A1 - 
AB - STUDY OBJECTIVE: Naloxone, an opioid-antagonist deliverable by an intra-nasal route, has become widely available and utilized by law enforcement officers as well as basic life support (BLS) providers in the prehospital setting. This study aimed to determine the frequency of repeat naloxone dosing in suspected narcotic overdose (OD) patients and identify patient characteristics. METHODS: A retrospective chart review of patients over 17 years of age with suspected opioid overdose, treated with an initial intranasal (IN) dose of naloxone and subsequently managed by paramedics, was performed from April 2014 to June 2016. Demographic data was analyzed using descriptive statistics to identify those aspects of the history, physical exam findings. Results: A sample size of 2166 patients with suspected opioid OD received naloxone from first responders. No patients who achieved GCS 15 after treatment required redosing; 195 (9%) received two doses and 53 patients received three doses of naloxone by advanced life support. Patients were primarily male (75.4%), Caucasian (88.2%), with a mean age of 36.4 years. A total of 76.7% of patients were found in the home, 23.1% had a suspected mixed ingestion, and 27.2% had a previous OD. Two percent of all patients required a third dose of naloxone. CONCLUSION: In this prehospital study, we confirmed that intranasal naloxone is effective in reversing suspected opioid toxicity. Nine percent of patients required two or more doses of naloxone to achieve clinical reversal of suspected opioid toxicity. Two percent of patients received a third dose of naloxone.
BT - Prehospital emergency care : official journal of the National Association of EMS Physicians and the National Association of State EMS Directors
C5 - Opioids & Substance Use
CP - 6
CY - England
DO - 10.1080/10903127.2017.1335818
IS - 6
JF - Prehospital emergency care : official journal of the National Association of EMS Physicians and the National Association of State EMS Directors
LA - eng
M1 - Journal Article
N2 - STUDY OBJECTIVE: Naloxone, an opioid-antagonist deliverable by an intra-nasal route, has become widely available and utilized by law enforcement officers as well as basic life support (BLS) providers in the prehospital setting. This study aimed to determine the frequency of repeat naloxone dosing in suspected narcotic overdose (OD) patients and identify patient characteristics. METHODS: A retrospective chart review of patients over 17 years of age with suspected opioid overdose, treated with an initial intranasal (IN) dose of naloxone and subsequently managed by paramedics, was performed from April 2014 to June 2016. Demographic data was analyzed using descriptive statistics to identify those aspects of the history, physical exam findings. Results: A sample size of 2166 patients with suspected opioid OD received naloxone from first responders. No patients who achieved GCS 15 after treatment required redosing; 195 (9%) received two doses and 53 patients received three doses of naloxone by advanced life support. Patients were primarily male (75.4%), Caucasian (88.2%), with a mean age of 36.4 years. A total of 76.7% of patients were found in the home, 23.1% had a suspected mixed ingestion, and 27.2% had a previous OD. Two percent of all patients required a third dose of naloxone. CONCLUSION: In this prehospital study, we confirmed that intranasal naloxone is effective in reversing suspected opioid toxicity. Nine percent of patients required two or more doses of naloxone to achieve clinical reversal of suspected opioid toxicity. Two percent of patients received a third dose of naloxone.
PP - England
PY - 2017
SN - 1545-0066; 1090-3127
SP - 682
EP - 687
EP - 
T1 - Incidence of Naloxone Redosing in the Age of the New Opioid Epidemic
T2 - Prehospital emergency care : official journal of the National Association of EMS Physicians and the National Association of State EMS Directors
TI - Incidence of Naloxone Redosing in the Age of the New Opioid Epidemic
U1 - Opioids & Substance Use
U2 - 28686547
U3 - 10.1080/10903127.2017.1335818
VL - 21
VO - 1545-0066; 1090-3127
Y1 - 2017
Y2 - Nov-Dec
ER -