TY - JOUR
KW - buprenorphine
KW - Humans
KW - Infant, Newborn
KW - Methadone
KW - Neonatal abstinence syndrome
KW - Opiate Substitution Treatment
KW - opioid-related disorders
KW - Pregnancy Complications
AU - Matthew R. Grossman
AU - Adam K. Berkwitt
AU - Rachel R. Osborn
A1 - 
AB - Several studies that have focused on deliberate, nonpharmacologic care have shown a reduced need for medications and substantially shorter lengths of stay than the BBORN trial, some as short as 5.9 days.2-4 With small group sizes in this trial, we cannot assume that disparate nonpharmacologic interventions were adequately addressed with randomization, and without controlling for these nonpharmacologic factors it is difficult to interpret the effect of differing pharmacologic therapies. The results of a trial that randomly assigned infants with the neonatal abstinence syndrome to various levels of nonpharmacologic care and that did not control for medication therapy would be similarly difficult to interpret. Nonpharmacologic care has been shown to be an effective therapy for infants with the neonatal abstinence syndrome, and it needs to be treated as such in the literature.
AD - Yale School of Medicine, New Haven, CT; matthew.grossman@yale.edu; Yale School of Medicine, New Haven, CT; Yale School of Medicine, New Haven, CT
BT - The New England journal of medicine
C5 - Healthcare Disparities; Opioids & Substance Use
CP - 10
CY - United States
DO - 10.1056/NEJMc1709121
IS - 10
JF - The New England journal of medicine
LA - eng
M1 - Journal Article
N2 - Several studies that have focused on deliberate, nonpharmacologic care have shown a reduced need for medications and substantially shorter lengths of stay than the BBORN trial, some as short as 5.9 days.2-4 With small group sizes in this trial, we cannot assume that disparate nonpharmacologic interventions were adequately addressed with randomization, and without controlling for these nonpharmacologic factors it is difficult to interpret the effect of differing pharmacologic therapies. The results of a trial that randomly assigned infants with the neonatal abstinence syndrome to various levels of nonpharmacologic care and that did not control for medication therapy would be similarly difficult to interpret. Nonpharmacologic care has been shown to be an effective therapy for infants with the neonatal abstinence syndrome, and it needs to be treated as such in the literature.
PP - United States
PY - 2017
SN - 1533-4406; 0028-4793
SP - 996
EP - 997
EP - 
T1 - Buprenorphine for the Neonatal Abstinence Syndrome
T2 - The New England journal of medicine
TI - Buprenorphine for the Neonatal Abstinence Syndrome
U1 - Healthcare Disparities; Opioids & Substance Use
U2 - 28880503
U3 - 10.1056/NEJMc1709121
VL - 377
VO - 1533-4406; 0028-4793
Y1 - 2017
Y2 - Sep 7
ER -