TY - JOUR KW - Humans KW - Mental Health Services KW - Primary Health Care KW - South Africa KW - Integrated mental healthcare KW - health systems KW - low-to-middle income country KW - primary healthcare KW - qualitative comparative analysis AU - Janse van Rensburg AU - T. Kathree AU - E. Breuer AU - O. Selohilwe AU - N. Mntambo AU - R. Petrus AU - A. Bhana AU - C. Lund AU - L. Fairall AU - I. Petersen A1 - AB - BACKGROUND: Integrating mental health services into primary healthcare platforms is an established health systems strategy in low-to-middle-income countries. In South Africa, this was pursued through the Programme for Improving Mental Health Care (PRIME), a multi-country initiative that relied on task-sharing as a principle implementation strategy. Towards better describing the implementation processes, qualitative comparative analysis was adopted to explore causal pathways in the intervention. OBJECTIVE: This study aimed to explore factors that could have influenced key outcomes of an integrated mental healthcare intervention in South Africa. METHODS: Drawing from an embedded multiple case study design, the analysis used qualitative comparative analysis. Focusing on nine PHC clinics in the Dr Kenneth Kaunda District as cases, with depression reduction scores set as outcome measures, trial data variables were modelled in a hypothetical causal process. A fuzzy-set qualitative comparative analysis was performed by 1) developing the research questions, 2) developing the fuzzy set, 3) testing necessity and 4) testing sufficiency. These steps were undertaken collaboratively among the research team. RESULTS: The data were calibrated during several meetings among team members to gain a degree of consensus. Necessity analyses suggested that none of the causal conditions exceeded the threshold of necessity and triviality, and confirmed the inclusion of relevant variables in line with the proposed models. Sufficiency analyses produced two configurations, which were subjected to standard and specific analyses. Ultimately, the results suggested that none of the causal conditions were necessary for a reduction in depression scores to occur, while programme fidelity was identified as a sufficient condition for a reduction in scores to occur. CONCLUSIONS: The study highlights the importance of understanding implementation pathways to enable better integration of mental health services within primary healthcare in low-to-middle-income settings. It underlines the importance of programme fidelity in achieving the goals of implementation. AD - Centre for Rural Health, University of KwaZulu-Natal, School of Nursing and Public Health, Durban, South Africa.; Centre for Rural Health, University of KwaZulu-Natal, Durban, South Africa.; Alan J Flisher Centre for Public Mental Health, University of Cape Town, Cape Town, South Africa.; Centre for Rural Health, University of KwaZulu-Natal, Durban, South Africa.; Centre for Rural Health, University of KwaZulu-Natal, Durban, South Africa.; Department of Psychology, University of KwaZulu-Natal, Durban, South Africa.; Centre for Rural Health, University of KwaZulu-Natal & South African Medical Research Council, Durban, South Africa.; Alan J Flisher Centre for Public Mental Health, University of Cape Town & Centre for Global Mental Health, King's College London, Cape Town, South Africa.; Centre for Knowledge Translation, University of Cape Town, Cape Town, South Africa.; Centre for Rural Health, University of KwaZulu-Natal, Durban, South Africa. BT - Global health action C5 - Education & Workforce CP - 1 DO - 10.1080/16549716.2021.1940761 IS - 1 JF - Global health action LA - eng M1 - Journal Article N2 - BACKGROUND: Integrating mental health services into primary healthcare platforms is an established health systems strategy in low-to-middle-income countries. In South Africa, this was pursued through the Programme for Improving Mental Health Care (PRIME), a multi-country initiative that relied on task-sharing as a principle implementation strategy. Towards better describing the implementation processes, qualitative comparative analysis was adopted to explore causal pathways in the intervention. OBJECTIVE: This study aimed to explore factors that could have influenced key outcomes of an integrated mental healthcare intervention in South Africa. METHODS: Drawing from an embedded multiple case study design, the analysis used qualitative comparative analysis. Focusing on nine PHC clinics in the Dr Kenneth Kaunda District as cases, with depression reduction scores set as outcome measures, trial data variables were modelled in a hypothetical causal process. A fuzzy-set qualitative comparative analysis was performed by 1) developing the research questions, 2) developing the fuzzy set, 3) testing necessity and 4) testing sufficiency. These steps were undertaken collaboratively among the research team. RESULTS: The data were calibrated during several meetings among team members to gain a degree of consensus. Necessity analyses suggested that none of the causal conditions exceeded the threshold of necessity and triviality, and confirmed the inclusion of relevant variables in line with the proposed models. Sufficiency analyses produced two configurations, which were subjected to standard and specific analyses. Ultimately, the results suggested that none of the causal conditions were necessary for a reduction in depression scores to occur, while programme fidelity was identified as a sufficient condition for a reduction in scores to occur. CONCLUSIONS: The study highlights the importance of understanding implementation pathways to enable better integration of mental health services within primary healthcare in low-to-middle-income settings. It underlines the importance of programme fidelity in achieving the goals of implementation. PY - 2021 SN - 1654-9880; 1654-9716; 1654-9880 SP - 1940761 T1 - Fuzzy-set qualitative comparative analysis of implementation outcomes in an integrated mental healthcare trial in South Africa T2 - Global health action TI - Fuzzy-set qualitative comparative analysis of implementation outcomes in an integrated mental healthcare trial in South Africa U1 - Education & Workforce U2 - 34402770 U3 - 10.1080/16549716.2021.1940761 VL - 14 VO - 1654-9880; 1654-9716; 1654-9880 Y1 - 2021 Y2 - Jan 1 ER -