TY - JOUR KW - Comorbidity KW - Humans KW - Opiate Overdose/prevention & control KW - Opiate Substitution Treatment KW - Opioid-Related Disorders/diagnosis/prevention & control KW - Primary Health Care KW - Risk Factors KW - United States AU - J. L. Taylor AU - J. H. Samet A1 - AB - Opioid use disorder (OUD) is a treatable chronic disorder with episodes of remission and recurrence characterized by loss of control of opioid use, compulsive use, and continued use despite harms. If untreated, OUD is associated with significant morbidity and mortality. Buprenorphine and methadone reduce fatal and nonfatal opioid overdose and infectious complications of OUD and are the first-line treatment options. Physicians have an important role to play in diagnosing OUD and its comorbidities, offering evidence-based treatment, and delivering overdose prevention and other harm reduction services to people who continue to use opioids. Interdisciplinary office-based addiction treatment programs support high-quality OUD care. AD - Section of General Internal Medicine, Boston University School of Medicine and Boston Medical Center, and Grayken Center for Addiction, Boston Medical Center, Boston, Massachusetts.; Section of General Internal Medicine, Boston University School of Medicine and Boston Medical Center, and Grayken Center for Addiction, Boston Medical Center, Boston, Massachusetts. BT - Annals of Internal Medicine C5 - Education & Workforce; Opioids & Substance Use CP - 1 CY - United States DO - 10.7326/AITC202201180 IS - 1 JF - Annals of Internal Medicine LA - eng M1 - Journal Article N2 - Opioid use disorder (OUD) is a treatable chronic disorder with episodes of remission and recurrence characterized by loss of control of opioid use, compulsive use, and continued use despite harms. If untreated, OUD is associated with significant morbidity and mortality. Buprenorphine and methadone reduce fatal and nonfatal opioid overdose and infectious complications of OUD and are the first-line treatment options. Physicians have an important role to play in diagnosing OUD and its comorbidities, offering evidence-based treatment, and delivering overdose prevention and other harm reduction services to people who continue to use opioids. Interdisciplinary office-based addiction treatment programs support high-quality OUD care. PP - United States PY - 2022 SN - 1539-3704; 0003-4819 SP - ITC1 EP - ITC16 EP - T1 - Opioid Use Disorder T2 - Annals of Internal Medicine TI - Opioid Use Disorder U1 - Education & Workforce; Opioids & Substance Use U2 - 35007147 U3 - 10.7326/AITC202201180 VL - 175 VO - 1539-3704; 0003-4819 Y1 - 2022 Y2 - Jan ER -