TY - JOUR KW - cocaine KW - Cocaine-Related Disorders/drug therapy KW - Humans KW - Substance-Related Disorders KW - development KW - medication KW - outcomes KW - pharmacotherapy KW - Research AU - S. Shoptaw AU - M. Trivedi AU - J. S. Potter A1 - AB - While thirty years of research into an effective cocaine pharmacotherapy has yielded no treatments, knowledge gained doing this work underscores the importance of rigorous clinical design, of attention to medication adherence and of defining endpoints. The field needs a high-risk/high-reward strategy to engineer new compounds that help people to use less cocaine and to preserve gains made during treatment, particularly during lapse/relapse. AD - Department of Family Medicine, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Psychiatry, University of Texas Southwestern, Dallas, TX, USA.; Department of Psychiatry, University of Texas Health Science Center, San Antonio, TX, USA. BT - Addiction (Abingdon, England) C5 - Education & Workforce; Opioids & Substance Use CP - 4 DO - 10.1111/add.15310 IS - 4 JF - Addiction (Abingdon, England) LA - eng M1 - Journal Article N2 - While thirty years of research into an effective cocaine pharmacotherapy has yielded no treatments, knowledge gained doing this work underscores the importance of rigorous clinical design, of attention to medication adherence and of defining endpoints. The field needs a high-risk/high-reward strategy to engineer new compounds that help people to use less cocaine and to preserve gains made during treatment, particularly during lapse/relapse. PY - 2021 SN - 1360-0443; 0965-2140; 0965-2140 SP - 714 EP - 715 EP - T1 - If there were an effective pharmacotherapy for cocaine use disorder, what would it do? T2 - Addiction (Abingdon, England) TI - If there were an effective pharmacotherapy for cocaine use disorder, what would it do? U1 - Education & Workforce; Opioids & Substance Use U2 - 33269478 U3 - 10.1111/add.15310 VL - 116 VO - 1360-0443; 0965-2140; 0965-2140 Y1 - 2021 Y2 - Apr ER -