TY - JOUR
KW - Adolescent
KW - Adult
KW - Analgesics, Opioid/adverse effects
KW - Body Mass Index
KW - Buprenorphine/therapeutic use
KW - Humans
KW - Middle Aged
KW - Narcotic Antagonists/therapeutic use
KW - Opiate Substitution Treatment
KW - Opioid-Related Disorders/drug therapy/psychology
KW - Quality of Life
KW - Severity of Illness Index
KW - Sickness Impact Profile
KW - Substance Withdrawal Syndrome/psychology
KW - Young Adult
AU - K. C. Heslin
AU - J. A. Stein
AU - K. G. Heinzerling
AU - D. Pan
AU - C. Magladry
AU - R. D. Hays
A1 - 
AB - PURPOSE: Previous work suggests that opioid users have lower health-related quality of life (HRQOL) than patients with more prevalent chronic illnesses such as hypertension or diabetes. Although comparisons with population norms are informative, studies of the correlates of HRQOL for opioid users are needed to plan clinical services. METHODS: We tested a conceptual model of the pathways between physiologic factors and symptoms in relation to HRQOL among 344 opioid users in a clinical trial. Physical and mental HRQOL were measured by the Short-Form (SF)-36; withdrawal signs, symptoms, and functioning were also measured with validated instruments. Using structural equation modeling, we tested hypotheses that medical history directly predicts withdrawal signs and symptoms, and that medical history, withdrawal signs and symptoms, and functioning predict the physical and mental HRQOL latent variables of the SF-36. RESULTS: Most hypothesized relationships were significant, and model fit was good. The model explained 36% of the variance in mental HRQOL and 34% of the variance in physical HRQOL. CONCLUSIONS: The conceptual framework appears valid for explaining variation in the physical and mental HRQOL of opioid users undergoing medically managed withdrawal. Analysis of longitudinal data would help to evaluate more rigorously the adequacy of the model for explaining HRQOL in opioid withdrawal.
BT - Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation
C5 - Opioids & Substance Use
CP - 8
CY - Netherlands
DO - 10.1007/s11136-011-9858-y
IS - 8
JF - Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation
N2 - PURPOSE: Previous work suggests that opioid users have lower health-related quality of life (HRQOL) than patients with more prevalent chronic illnesses such as hypertension or diabetes. Although comparisons with population norms are informative, studies of the correlates of HRQOL for opioid users are needed to plan clinical services. METHODS: We tested a conceptual model of the pathways between physiologic factors and symptoms in relation to HRQOL among 344 opioid users in a clinical trial. Physical and mental HRQOL were measured by the Short-Form (SF)-36; withdrawal signs, symptoms, and functioning were also measured with validated instruments. Using structural equation modeling, we tested hypotheses that medical history directly predicts withdrawal signs and symptoms, and that medical history, withdrawal signs and symptoms, and functioning predict the physical and mental HRQOL latent variables of the SF-36. RESULTS: Most hypothesized relationships were significant, and model fit was good. The model explained 36% of the variance in mental HRQOL and 34% of the variance in physical HRQOL. CONCLUSIONS: The conceptual framework appears valid for explaining variation in the physical and mental HRQOL of opioid users undergoing medically managed withdrawal. Analysis of longitudinal data would help to evaluate more rigorously the adequacy of the model for explaining HRQOL in opioid withdrawal.
PP - Netherlands
PY - 2011
SN - 1573-2649; 0962-9343
SP - 1205
EP - 1213
EP - 
T1 - Clinical correlates of health-related quality of life among opioid-dependent patients
T2 - Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation
TI - Clinical correlates of health-related quality of life among opioid-dependent patients
U1 - Opioids & Substance Use
U2 - 21328090
U3 - 10.1007/s11136-011-9858-y
VL - 20
VO - 1573-2649; 0962-9343
Y1 - 2011
ER -