TY - JOUR
KW - Alcohol Deterrents/therapeutic use
KW - Alcoholism/drug therapy/epidemiology
KW - Animals
KW - Brain/drug effects
KW - Comorbidity
KW - Disease Models, Animal
KW - Humans
KW - Narcotic Antagonists/therapeutic use
KW - Opiate Substitution Treatment/methods
KW - Opioid-Related Disorders/drug therapy/epidemiology
KW - Prevalence
KW - AUD
KW - Alcohol
KW - OUD
KW - Co-morbidity
KW - co-use
KW - Opiate
KW - Opioid
KW - pharmacotherapies
AU - L. E. Hood
AU - J. M. Leyrer-Jackson
AU - M. F. Olive
A1 - 
AB - Opioid use disorder (OUD) and alcohol use disorder (AUD) are two highly prevalent substance-related disorders worldwide. Co-use of the substances is also quite prevalent, yet there are no pharmacological treatment approaches specifically designed to treat co-morbid OUD and AUD. Here, the authors critically summarize OUD, AUD and opioid/alcohol co-use and their current pharmacotherapies for treatment. They also review the mechanisms of action of opioids and alcohol within the brain reward circuitry and discuss potential combined mechanisms of action and resulting neuroadaptations. Pharmacotherapies that aim to treat AUD or OUD that may be beneficial in the treatment of co-use are also highlighted. Preclinical models assessing alcohol and opioid co-use remain sparse. Lasting neuroadaptations in brain reward circuits caused by co-use of alcohol and opioids remains largely understudied. In order to fully understand the neurobiological underpinnings of alcohol and opioid co-use and develop efficacious pharmacotherapies, the preclinical field must expand its current experimental paradigms of 'single drug' use to encompass polysubstance use. Such studies will provide insights on the neural alterations induced by opioid and alcohol co-use, and may help develop novel pharmacotherapies for individuals with co-occurring alcohol and opioid use disorders.
AD - Department of Psychology, Arizona State University , Tempe, AZ, USA.; Department of Psychology, Arizona State University , Tempe, AZ, USA.; Department of Psychology, Arizona State University , Tempe, AZ, USA.
BT - Expert opinion on pharmacotherapy
C5 - Opioids & Substance Use; Healthcare Disparities
CP - 7
DO - 10.1080/14656566.2020.1732349
IS - 7
JF - Expert opinion on pharmacotherapy
LA - eng
M1 - Journal Article
N2 - Opioid use disorder (OUD) and alcohol use disorder (AUD) are two highly prevalent substance-related disorders worldwide. Co-use of the substances is also quite prevalent, yet there are no pharmacological treatment approaches specifically designed to treat co-morbid OUD and AUD. Here, the authors critically summarize OUD, AUD and opioid/alcohol co-use and their current pharmacotherapies for treatment. They also review the mechanisms of action of opioids and alcohol within the brain reward circuitry and discuss potential combined mechanisms of action and resulting neuroadaptations. Pharmacotherapies that aim to treat AUD or OUD that may be beneficial in the treatment of co-use are also highlighted. Preclinical models assessing alcohol and opioid co-use remain sparse. Lasting neuroadaptations in brain reward circuits caused by co-use of alcohol and opioids remains largely understudied. In order to fully understand the neurobiological underpinnings of alcohol and opioid co-use and develop efficacious pharmacotherapies, the preclinical field must expand its current experimental paradigms of 'single drug' use to encompass polysubstance use. Such studies will provide insights on the neural alterations induced by opioid and alcohol co-use, and may help develop novel pharmacotherapies for individuals with co-occurring alcohol and opioid use disorders.
PY - 2020
SN - 1744-7666; 1465-6566; 1465-6566
SP - 823
EP - 839
EP - 
T1 - Pharmacotherapeutic management of co-morbid alcohol and opioid use
T2 - Expert opinion on pharmacotherapy
TI - Pharmacotherapeutic management of co-morbid alcohol and opioid use
U1 - Opioids & Substance Use; Healthcare Disparities
U2 - 32103695
U3 - 10.1080/14656566.2020.1732349
VL - 21
VO - 1744-7666; 1465-6566; 1465-6566
Y1 - 2020
Y2 - May
ER -