TY - JOUR
KW - Analgesics, Opioid/adverse effects
KW - Behavior, Addictive/drug therapy/epidemiology/physiopathology
KW - Habits
KW - Humans
KW - Methadone/therapeutic use
KW - Opioid-Related Disorders/drug therapy/epidemiology/physiopathology
KW - Substance Withdrawal Syndrome/drug therapy/epidemiology/physiopathology
AU - M. C. Beneitez
AU - M. E. Gil-Alegre
A1 - 
AB - BACKGROUND: Detoxification programmes seek to implement the most secure and compassionate ways of withdrawing from opiates so that the inevitable withdrawal symptoms and other complications are minimized. Once detoxification has been achieved, the next stage is to enable the patient to overcome his or her drug addiction by ensuring consumption is permanently and completely abandoned, only after which can the subject be regarded as fully recovered. METHODS: A systematic search on the common databases of relevant papers published until 2016 inclusive. RESULTS AND CONCLUSION: Our study of the available oral treatments for opioid dependence has revealed that no current treatment can actually claim to be fully effective. These treatments require daily oral administration and, consequently, regular visits to dispensaries, which in most cases results in a lack of patient compliance, which causes fluctuations in drug plasma levels. We then reviewed alternative treatments in the available scientific literature on polymeric sustained release formulations. Research has been done not only on release systems for detoxification but also on release systems for giving up the habit of taking opioids. These efforts have obtained the recent authorization of polymeric systems for use in patients that could help them to reduce their craving for drugs.
AD - Department of Pharmacy and Pharmaceutical Technology, Complutense University of Madrid, 28040 Madrid, Spain.; Department of Pharmacy and Pharmaceutical Technology, Complutense University of Madrid, 28040 Madrid, Spain.; University Institute of Industrial Pharmacy, Complutense University of Madrid, 28040 Madrid, Spain.
BT - BioMed research international
C5 - Opioids & Substance Use
CY - United States
DO - 10.1155/2017/7120815
JF - BioMed research international
M1 - Journal Article
N2 - BACKGROUND: Detoxification programmes seek to implement the most secure and compassionate ways of withdrawing from opiates so that the inevitable withdrawal symptoms and other complications are minimized. Once detoxification has been achieved, the next stage is to enable the patient to overcome his or her drug addiction by ensuring consumption is permanently and completely abandoned, only after which can the subject be regarded as fully recovered. METHODS: A systematic search on the common databases of relevant papers published until 2016 inclusive. RESULTS AND CONCLUSION: Our study of the available oral treatments for opioid dependence has revealed that no current treatment can actually claim to be fully effective. These treatments require daily oral administration and, consequently, regular visits to dispensaries, which in most cases results in a lack of patient compliance, which causes fluctuations in drug plasma levels. We then reviewed alternative treatments in the available scientific literature on polymeric sustained release formulations. Research has been done not only on release systems for detoxification but also on release systems for giving up the habit of taking opioids. These efforts have obtained the recent authorization of polymeric systems for use in patients that could help them to reduce their craving for drugs.
PP - United States
PY - 2017
SN - 2314-6141
SP - 7120815
T1 - Opioid Addiction: Social Problems Associated and Implications of Both Current and Possible Future Treatments, including Polymeric Therapeutics for Giving Up the Habit of Opioid Consumption
T2 - BioMed research international
TI - Opioid Addiction: Social Problems Associated and Implications of Both Current and Possible Future Treatments, including Polymeric Therapeutics for Giving Up the Habit of Opioid Consumption
U1 - Opioids & Substance Use
U2 - 28607934
U3 - 10.1155/2017/7120815
VL - 2017
VO - 2314-6141
Y1 - 2017
ER -