TY - JOUR
KW - Buprenorphine/therapeutic use
KW - Humans
KW - Naloxone/therapeutic use
KW - Narcotic Antagonists/therapeutic use
KW - Opioid-Related Disorders/drug therapy
KW - buprenorphine
KW - Methadone
KW - Opioid
KW - opioid dependence
KW - outcome
KW - treatment
AU - M. Soyka
A1 - 
AB - Opioid maintenance treatment is the first-line approach in opioid dependence. Both the full opioid agonist methadone (MET) and the partial agonist buprenorphine (BUP) are licensed for the treatment of opioid dependence. BUP differs significantly from MET in its pharmacology, side effects, and safety issues. For example, the risk of respiratory depression is lower than with MET. The risk of diversion and injection of BUP have been reduced by also making it available as a tablet containing the opioid antagonist naloxone. This review summarizes the clinical effects of BUP and examines possible factors that can support decisions regarding the use of BUP or MET in opioid-dependent people.
AD - Medical Park Chiemseeblick, Bernau, Germany; Psychiatric Hospital, University of Munich, Munich, Germany.
BT - Dialogues in clinical neuroscience
C5 - Opioids & Substance Use
CP - 3
CY - France
IS - 3
JF - Dialogues in clinical neuroscience
M1 - Journal Article
N2 - Opioid maintenance treatment is the first-line approach in opioid dependence. Both the full opioid agonist methadone (MET) and the partial agonist buprenorphine (BUP) are licensed for the treatment of opioid dependence. BUP differs significantly from MET in its pharmacology, side effects, and safety issues. For example, the risk of respiratory depression is lower than with MET. The risk of diversion and injection of BUP have been reduced by also making it available as a tablet containing the opioid antagonist naloxone. This review summarizes the clinical effects of BUP and examines possible factors that can support decisions regarding the use of BUP or MET in opioid-dependent people.
PP - France
PY - 2017
SN - 1958-5969; 1294-8322
SP - 299
EP - 308
EP - 
T1 - Treatment of opioid dependence with buprenorphine: current update
T2 - Dialogues in clinical neuroscience
TI - Treatment of opioid dependence with buprenorphine: current update
U1 - Opioids & Substance Use
U2 - 29302227
VL - 19
VO - 1958-5969; 1294-8322
Y1 - 2017
Y2 - Sep
ER -