TY - JOUR
KW - Adolescent
KW - Adult
KW - Aged
KW - Buprenorphine/administration & dosage
KW - Cross-Sectional Studies
KW - Erectile Dysfunction
KW - Humans
KW - Male
KW - Methadone/administration & dosage
KW - Middle Aged
KW - Opiate Substitution Treatment/adverse effects
KW - Opioid-Related Disorders/drug therapy/physiopathology
KW - Quality of Life
KW - Young Adult
AU - F. Lugoboni
AU - L. Zamboni
AU - A. Federico
AU - S. Tamburin
AU - Gruppo InterSERT di Collaborazione Scientifica
A1 - 
AB - BACKGROUND: Erectile dysfunction (ED) is common among men on opioid replacement therapy (ORT), but most previous studies exploring its prevalence and determinants yielded contrasting findings. Moreover, the impact of ED on patients' quality of life (QoL) has been seldom explored. OBJECTIVE: To explore the prevalence and determinants of ED in men on ORT, and the impact on QoL. METHODS: In a multicentre cross-sectional study, we recruited 797 consecutive male patients on methadone and buprenorphine treatment, collected data on demographic, clinical, and psychopathological factors, and explored their role as predictors of ED and QoL through univariate and multivariate analysis. ED severity was assessed with a self-assessment questionnaire. RESULTS: Nearly half of patients in our sample were sexually inactive or reported some degree of ED. Some demographic, clinical and psychopathological variables significantly differed according to the presence or absence of ED. Multivariate regression analysis indicated that age, employment, smoke, psychoactive drugs, opioid maintenance dosage, and severity of psychopathological factors significantly influenced the risk and severity of ED. QoL was worse in patients with ED and significantly correlated with ED severity. Age, education, employment, opioid maintenance dosage, ED score, and severity of psychopathology significantly influenced QoL in the multivariate analysis. CONCLUSIONS: ED complaints can be explored in male opioid users on ORT through a simple and quick self-assessment tool. ED may have important effects on emotional and social well-being, and may affect outcome.
AD - Department of Medicine, Addiction Medicine Unit, Verona University Hospital, Verona, Italy.; Department of Medicine, Addiction Medicine Unit, Verona University Hospital, Verona, Italy.; Department of Medicine, Addiction Medicine Unit, Verona University Hospital, Verona, Italy.; Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.; Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
BT - PloS one
C5 - Opioids & Substance Use
CP - 11
CY - United States
DO - 10.1371/journal.pone.0188994
IS - 11
JF - PloS one
M1 - Journal Article
N2 - BACKGROUND: Erectile dysfunction (ED) is common among men on opioid replacement therapy (ORT), but most previous studies exploring its prevalence and determinants yielded contrasting findings. Moreover, the impact of ED on patients' quality of life (QoL) has been seldom explored. OBJECTIVE: To explore the prevalence and determinants of ED in men on ORT, and the impact on QoL. METHODS: In a multicentre cross-sectional study, we recruited 797 consecutive male patients on methadone and buprenorphine treatment, collected data on demographic, clinical, and psychopathological factors, and explored their role as predictors of ED and QoL through univariate and multivariate analysis. ED severity was assessed with a self-assessment questionnaire. RESULTS: Nearly half of patients in our sample were sexually inactive or reported some degree of ED. Some demographic, clinical and psychopathological variables significantly differed according to the presence or absence of ED. Multivariate regression analysis indicated that age, employment, smoke, psychoactive drugs, opioid maintenance dosage, and severity of psychopathological factors significantly influenced the risk and severity of ED. QoL was worse in patients with ED and significantly correlated with ED severity. Age, education, employment, opioid maintenance dosage, ED score, and severity of psychopathology significantly influenced QoL in the multivariate analysis. CONCLUSIONS: ED complaints can be explored in male opioid users on ORT through a simple and quick self-assessment tool. ED may have important effects on emotional and social well-being, and may affect outcome.
PP - United States
PY - 2017
SN - 1932-6203; 1932-6203
T1 - Erectile dysfunction and quality of life in men receiving methadone or buprenorphine maintenance treatment. A cross-sectional multicentre study
T2 - PloS one
TI - Erectile dysfunction and quality of life in men receiving methadone or buprenorphine maintenance treatment. A cross-sectional multicentre study
U1 - Opioids & Substance Use
U2 - 29190831
U3 - 10.1371/journal.pone.0188994
VL - 12
VO - 1932-6203; 1932-6203
Y1 - 2017
Y2 - Nov 30
ER -