TY - JOUR
KW - Adult
KW - Buprenorphine/therapeutic use
KW - Family Practice
KW - Female
KW - Humans
KW - Infant, Newborn
KW - Internship and Residency
KW - Narcotic Antagonists/therapeutic use
KW - Neonatal Abstinence Syndrome/prevention & control
KW - Opiate Substitution Treatment
KW - Opioid-Related Disorders/drug therapy
KW - Pregnancy
KW - Pregnancy Complications/drug therapy
KW - Retrospective Studies
KW - Treatment Outcome
KW - Young Adult
AU - A. O'Connor
AU - W. Alto
AU - K. Musgrave
AU - D. Gibbons
AU - L. Llanto
AU - S. Holden
AU - J. Karnes
A1 - 
AB - PURPOSE: Within a family medicine residency, an outpatient buprenorphine treatment program was provided for pregnant women who were dependent on opioids. The purpose of this study was to investigate the outcomes of infants who were exposed to a range of doses of buprenorphine in utero and to determine how closely observed maternal/fetal outcomes (eg, method of delivery and infants requiring treatment for neonatal abstinence syndrome [NAS]) match those previously reported in the literature. METHODS: This study consists of a retrospective case series of 23 infants born to 22 pregnant women who were dependent on opioids and who were treated with buprenorphine during a 31-month period. RESULTS: Thirty-five percent of infants (8 of 23) required treatment for NAS. There was no significant relationship between maternal dose of buprenorphine and birth weight, NAS severity (ie, peak NAS score), or time to first peak NAS score. Infants born to tobacco users had a significantly lower birth weight (P = .0136) than infants born to nonusers. Seventy percent of infants (16 of 23) were breastfeeding at the time of discharge from the hospital. CONCLUSIONS: The observations made in this case series are consistent with data previously reported in the literature. Infants in this study were more likely to be breastfed than those previously described by others, but further analysis is necessary to determine whether this finding is significant.
BT - Journal of the American Board of Family Medicine : JABFM
C5 - Opioids & Substance Use
CP - 2
CY - United States
DO - 10.3122/jabfm.2011.02.100155
IS - 2
JF - Journal of the American Board of Family Medicine : JABFM
N2 - PURPOSE: Within a family medicine residency, an outpatient buprenorphine treatment program was provided for pregnant women who were dependent on opioids. The purpose of this study was to investigate the outcomes of infants who were exposed to a range of doses of buprenorphine in utero and to determine how closely observed maternal/fetal outcomes (eg, method of delivery and infants requiring treatment for neonatal abstinence syndrome [NAS]) match those previously reported in the literature. METHODS: This study consists of a retrospective case series of 23 infants born to 22 pregnant women who were dependent on opioids and who were treated with buprenorphine during a 31-month period. RESULTS: Thirty-five percent of infants (8 of 23) required treatment for NAS. There was no significant relationship between maternal dose of buprenorphine and birth weight, NAS severity (ie, peak NAS score), or time to first peak NAS score. Infants born to tobacco users had a significantly lower birth weight (P = .0136) than infants born to nonusers. Seventy percent of infants (16 of 23) were breastfeeding at the time of discharge from the hospital. CONCLUSIONS: The observations made in this case series are consistent with data previously reported in the literature. Infants in this study were more likely to be breastfed than those previously described by others, but further analysis is necessary to determine whether this finding is significant.
PP - United States
PY - 2011
SN - 1557-2625; 1557-2625
SP - 194
EP - 201
EP - 
T1 - Observational study of buprenorphine treatment of opioid-dependent pregnant women in a family medicine residency: Reports on maternal and infant outcomes
T2 - Journal of the American Board of Family Medicine : JABFM
TI - Observational study of buprenorphine treatment of opioid-dependent pregnant women in a family medicine residency: Reports on maternal and infant outcomes
U1 - Opioids & Substance Use
U2 - 21383220
U3 - 10.3122/jabfm.2011.02.100155
VL - 24
VO - 1557-2625; 1557-2625
Y1 - 2011
ER -