TY - JOUR
KW - Adult
KW - Analgesics, Opioid/blood/poisoning
KW - Autopsy
KW - Benzamides/blood/poisoning
KW - Cause of Death
KW - Chromatography, Liquid
KW - Drug overdose
KW - Fatal Outcome
KW - Gas Chromatography-Mass Spectrometry
KW - Humans
KW - Male
KW - Opioid-Related Disorders/blood/diagnosis/etiology
KW - Substance Abuse Detection/methods
KW - Tandem Mass Spectrometry
AU - T. P. Rohrig
AU - S. A. Miller
AU - T. R. Baird
A1 - 
AB - U-47700 was developed by the Upjohn Co. in the 1970s as part of their search for a selective mu-opioid agonist with similar potency as morphine. U-47700 has re-emerged recently in the illicit drug market and is easily and cheaply obtained via the internet as well as on the street, many times falsely sold as another drug. Several fatalities from U-47700 have been reported in scientific literature, often in combination with other intoxicants. This case report describes the first death in south-central Kansas resulting solely from U-47700 intoxication: a 26-year-old white male found dead in his bedroom with apparent drug paraphernalia. Autopsy findings were consistent with opioid overdose, but toxicological examination, utilizing immunoassay and instrumental techniques, was negative for opioids. U-47700 was detected in a comprehensive alkaloid screen by GC/MS and GC-NPD, and quantitation was performed using GC-NPD on a variety of specimens to provide a full tissue distribution. Quantitation of U-47700 in this individual revealed the following: heart blood 0.26 mg/L, femoral blood 0.40 mg/L, vitreous fluid 0.09 mg/L, brain 0.38 mg/kg, liver 0.28 mg/kg and urine 4.6 mg/L.
BT - Journal of analytical toxicology
C5 - Opioids & Substance Use
CP - 1
CY - England
DO - 10.1093/jat/bkx081
IS - 1
JF - Journal of analytical toxicology
N2 - U-47700 was developed by the Upjohn Co. in the 1970s as part of their search for a selective mu-opioid agonist with similar potency as morphine. U-47700 has re-emerged recently in the illicit drug market and is easily and cheaply obtained via the internet as well as on the street, many times falsely sold as another drug. Several fatalities from U-47700 have been reported in scientific literature, often in combination with other intoxicants. This case report describes the first death in south-central Kansas resulting solely from U-47700 intoxication: a 26-year-old white male found dead in his bedroom with apparent drug paraphernalia. Autopsy findings were consistent with opioid overdose, but toxicological examination, utilizing immunoassay and instrumental techniques, was negative for opioids. U-47700 was detected in a comprehensive alkaloid screen by GC/MS and GC-NPD, and quantitation was performed using GC-NPD on a variety of specimens to provide a full tissue distribution. Quantitation of U-47700 in this individual revealed the following: heart blood 0.26 mg/L, femoral blood 0.40 mg/L, vitreous fluid 0.09 mg/L, brain 0.38 mg/kg, liver 0.28 mg/kg and urine 4.6 mg/L.
PP - England
PY - 2018
SN - 1945-2403; 0146-4760
SP - e12
EP - e14
EP - 
T1 - U-47700: A Not So New Opioid
T2 - Journal of analytical toxicology
TI - U-47700: A Not So New Opioid
U1 - Opioids & Substance Use
U2 - 29040568
U3 - 10.1093/jat/bkx081
VL - 42
VO - 1945-2403; 0146-4760
Y1 - 2018
ER -