TY - JOUR AU - M. A. Oquendo AU - N. D. Volkow A1 - AB - As the toll of opioid-overdose deaths in the United States rises, we face an urgent need for prevention. But preventing such deaths will require a better understanding of the diverse trajectories by which overdoses occur, including the distinction between intentional (suicide) and unintentional (accidental) deaths, be they in patients with chronic pain who overdose on their opioid analgesics or in those with a primary opioid use disorder (OUD). Interventions to prevent overdose deaths in suicidal people will differ from interventions targeted at accidental overdoses. Yet most strategies for reducing opioid-overdose deaths do not include screening for suicide risk, nor do they address the need to tailor interventions for suicidal persons. Moreover, the inaccuracy of available data on the proportion of suicides among opioid-overdose deaths � which are frequently classified as �undetermined� if there is no documented history of depression or a suicide note � hinders deployment of appropriate prevention services. BT - New England Journal of Medicine C5 - Opioids & Substance Use CP - 17 DO - 10.1056/NEJMp1801417 IS - 17 JF - New England Journal of Medicine N2 - As the toll of opioid-overdose deaths in the United States rises, we face an urgent need for prevention. But preventing such deaths will require a better understanding of the diverse trajectories by which overdoses occur, including the distinction between intentional (suicide) and unintentional (accidental) deaths, be they in patients with chronic pain who overdose on their opioid analgesics or in those with a primary opioid use disorder (OUD). Interventions to prevent overdose deaths in suicidal people will differ from interventions targeted at accidental overdoses. Yet most strategies for reducing opioid-overdose deaths do not include screening for suicide risk, nor do they address the need to tailor interventions for suicidal persons. Moreover, the inaccuracy of available data on the proportion of suicides among opioid-overdose deaths � which are frequently classified as �undetermined� if there is no documented history of depression or a suicide note � hinders deployment of appropriate prevention services. PY - 2018 SP - 1567 EP - 1569 EP - T1 - Suicide: A Silent Contributor to Opioid-Overdose Deaths T2 - New England Journal of Medicine TI - Suicide: A Silent Contributor to Opioid-Overdose Deaths U1 - Opioids & Substance Use U2 - 29694805 U3 - 10.1056/NEJMp1801417 VL - 378 Y1 - 2018 ER -