TY - JOUR KW - Adult KW - Anxiety Disorders/psychology/therapy KW - Case Management/organization & administration KW - Community Mental Health Services/methods/utilization KW - Female KW - Follow-Up Studies KW - Health Services Research KW - Humans KW - Male KW - Outcome Assessment (Health Care) KW - Panic Disorder/psychology/therapy KW - Patient Care Team/organization & administration KW - Patient Education as Topic/methods KW - Patient Selection KW - Primary Health Care/organization & administration KW - Quality of Health Care KW - Telemedicine/methods KW - Telephone KW - Treatment Outcome KW - Utilization Review AU - B. L. Rollman AU - B. H. Belnap AU - S. Mazumdar AU - P. R. Houck AU - F. Zhu AU - W. Gardner AU - C. F. Reynolds III AU - H. C. Schulberg AU - M. K. Shear A1 - AB - CONTEXT: Panic disorder and generalized anxiety disorder are prevalent in primary care, associated with poor functional outcomes, and are often unrecognized and ineffectively treated by primary care physicians. OBJECTIVE: To examine whether telephone-based collaborative care for panic and generalized anxiety disorders improves clinical and functional outcomes more than the usual care provided by primary care physicians. DESIGN: Randomized controlled trial. SETTING: Four Pittsburgh area primary care practices linked by a common electronic medical record system. Patients A total of 191 adults aged 18 to 64 years with panic and/or generalized anxiety disorder who were recruited from July 2000 to April 2002. Intervention Patients were randomly assigned to a telephone-based care management intervention (n = 116) or to notification alone of the anxiety disorder to patients and their physicians (usual care, n = 75). The intervention involved non-mental health professionals who provided patients with psychoeducation, assessed preferences for guideline-based care, monitored treatment responses, and informed physicians of their patients' care preferences and progress via an electronic medical record system under the direction of study investigators. MAIN OUTCOME MEASURES: Independent blinded assessments of anxiety and depressive symptoms, mental health-related quality of life, and employment status at baseline, 2-, 4-, 8-, and 12-month follow-up. RESULTS: At 12-month follow-up, intervention patients reported reduced anxiety (effect size [ES], 0.33-0.38; 95% confidence interval [CI], 0.04 to 0.67; P