TY - JOUR
KW - Adolescent
KW - Adult
KW - Analgesics, Opioid/chemistry/therapeutic use/urine
KW - Chemistry, Pharmaceutical
KW - Delayed-Action Preparations
KW - Female
KW - Humans
KW - Male
KW - Medical Records
KW - Methadone/therapeutic use
KW - Middle Aged
KW - Ontario
KW - Opiate Substitution Treatment
KW - Opioid-Related Disorders/diagnosis/rehabilitation/urine
KW - Oxycodone/chemistry/urine
KW - Prescription Drug Misuse/prevention & control
KW - Prospective Studies
KW - Retrospective Studies
KW - Substance Abuse Detection/methods
KW - Surveys and Questionnaires
KW - Urinalysis
KW - Young Adult
AU - C. Sankey
AU - B. Setnik
AU - Z. Harsanyi
AU - K. Michalko
AU - Z. Yang
AU - P. Geoffroy
A1 - 
AB - OBJECTIVE: Emerging data are demonstrating that tamper-resistant opioids may play an important role in changing prescription opioid abuse behaviors. This study was a chart review to examine if the reformulation of OxyContin(R) into a version with tamper-resistant properties (OxyNEO(R)) had an impact on oxycodone-positive urine drug screens (UDSs) in opioid-dependent patients receiving methadone maintenance therapy (MMT). DESIGN: The historical element of this study examined 250 eligible charts from patients on MMT who had data during the time periods when only OxyContin was available (baseline period), during the transition to OxyNEO, and when only OxyNEO was available. The prospective element included an exploratory questionnaire regarding retrospective opioid use. SETTING: The study was conducted at three methadone clinics, in Oshawa, Peterborough, and Scarborough in Ontario, Canada. PARTICIPANTS: Male and female patients were eligible if they had a diagnosis of opioid dependency, received MMT, and had at least one oxycodone-positive UDS during the baseline period. INTERVENTION: This was a noninterventional study. MAIN OUTCOME MEASURE: The main outcome was the number of oxycodonepositive UDSs. RESULTS: The results demonstrated a marked reduction in oxycodone-positive UDSs that showed stepwise, statistically significant decreases during the transition and post-OxyContin periods relative to baseline. While the oxycodone-positive UDS results were decreasing, morphine-related-positive UDSs remained relatively stable during the same periods. There were no significant gender differences noted. CONCLUSIONS: The introduction of OxyNEO was associated with a statistically significant reduction in oxycodone exposure in a population of methadone-maintained patients.
BT - Journal of opioid management
C5 - Opioids & Substance Use
CP - 2
CY - United States
DO - 10.5055/jom.2016.0327
IS - 2
JF - Journal of opioid management
N2 - OBJECTIVE: Emerging data are demonstrating that tamper-resistant opioids may play an important role in changing prescription opioid abuse behaviors. This study was a chart review to examine if the reformulation of OxyContin(R) into a version with tamper-resistant properties (OxyNEO(R)) had an impact on oxycodone-positive urine drug screens (UDSs) in opioid-dependent patients receiving methadone maintenance therapy (MMT). DESIGN: The historical element of this study examined 250 eligible charts from patients on MMT who had data during the time periods when only OxyContin was available (baseline period), during the transition to OxyNEO, and when only OxyNEO was available. The prospective element included an exploratory questionnaire regarding retrospective opioid use. SETTING: The study was conducted at three methadone clinics, in Oshawa, Peterborough, and Scarborough in Ontario, Canada. PARTICIPANTS: Male and female patients were eligible if they had a diagnosis of opioid dependency, received MMT, and had at least one oxycodone-positive UDS during the baseline period. INTERVENTION: This was a noninterventional study. MAIN OUTCOME MEASURE: The main outcome was the number of oxycodonepositive UDSs. RESULTS: The results demonstrated a marked reduction in oxycodone-positive UDSs that showed stepwise, statistically significant decreases during the transition and post-OxyContin periods relative to baseline. While the oxycodone-positive UDS results were decreasing, morphine-related-positive UDSs remained relatively stable during the same periods. There were no significant gender differences noted. CONCLUSIONS: The introduction of OxyNEO was associated with a statistically significant reduction in oxycodone exposure in a population of methadone-maintained patients.
PP - United States
PY - 2016
SN - 1551-7489; 1551-7489
SP - 149
EP - 159
EP - 
T1 - Opioid use following the introduction of an extended-release oxycodone formulation with tamper-resistant properties: Prospective historical chart review in methadone-maintained patients
T2 - Journal of opioid management
TI - Opioid use following the introduction of an extended-release oxycodone formulation with tamper-resistant properties: Prospective historical chart review in methadone-maintained patients
U1 - Opioids & Substance Use
U2 - 27194200
U3 - 10.5055/jom.2016.0327
VL - 12
VO - 1551-7489; 1551-7489
Y1 - 2016
ER -