TY - JOUR KW - Brain Diseases/physiopathology KW - Humans KW - Models, Neurological KW - Substance Withdrawal Syndrome/physiopathology KW - Substance-Related Disorders/physiopathology/psychology AU - N. D. Volkow AU - G. F. Koob AU - A. T. McLellan A1 - AB - This article reviews scientific advances in the prevention and treatment of substance-use disorder and related developments in public policy. BT - The New England Journal of Medicine C5 - Opioids & Substance Use; Healthcare Policy CP - 4 CY - United States DO - 10.1056/NEJMra1511480 IS - 4 JF - The New England Journal of Medicine N2 - This article reviews scientific advances in the prevention and treatment of substance-use disorder and related developments in public policy. PP - United States PY - 2016 SN - 1533-4406; 0028-4793 SP - 363 EP - 371 EP - T1 - Neurobiologic Advances from the Brain Disease Model of Addiction T2 - The New England Journal of Medicine TI - Neurobiologic Advances from the Brain Disease Model of Addiction U1 - Opioids & Substance Use; Healthcare Policy U2 - 26816013 U3 - 10.1056/NEJMra1511480 VL - 374 VO - 1533-4406; 0028-4793 Y1 - 2016 ER -