TY - JOUR
KW - Adult
KW - Buprenorphine/therapeutic use
KW - Drug Combinations
KW - Female
KW - Humans
KW - Methadone/therapeutic use
KW - Naloxone/therapeutic use
KW - Narcotic Antagonists/therapeutic use
KW - Narcotics/therapeutic use
KW - Opioid-Related Disorders/diagnosis/drug therapy
KW - Patient Care Planning/standards
KW - Physician's Role
KW - Primary Health Care/standards
AU - L. E. Sullivan
AU - D. A. Fiellin
A1 - 
AB - The profile of opioid dependence in the United States is changing. Abuse of prescription opioids is more common than that of illicit opioids: Recent data indicate that approximately 1.6 million persons abuse or are dependent on prescription opioids, whereas 323,000 abuse or are dependent on heroin. Despite this prevalence, nearly 80% of opioid-dependent persons remain untreated. One option for expanding treatment is the use of buprenorphine and the buprenorphine-naloxone combination. Buprenorphine is a partial opioid agonist that can be prescribed by trained physicians and dispensed at pharmacies. This article addresses the clinical presentation of a patient with opioid dependence and describes the relatively new practice of office-based treatment with buprenorphine-naloxone. The different components of treatment; the role of the physician who provides this treatment; and the logistics of treating this growing, multifaceted patient population are also examined.
BT - Annals of Internal Medicine
C5 - Opioids & Substance Use
CP - 9
CY - United States
DO - https://doi.org/10.7326/0003-4819-148-9-200805060-00006
IS - 9
JF - Annals of Internal Medicine
N2 - The profile of opioid dependence in the United States is changing. Abuse of prescription opioids is more common than that of illicit opioids: Recent data indicate that approximately 1.6 million persons abuse or are dependent on prescription opioids, whereas 323,000 abuse or are dependent on heroin. Despite this prevalence, nearly 80% of opioid-dependent persons remain untreated. One option for expanding treatment is the use of buprenorphine and the buprenorphine-naloxone combination. Buprenorphine is a partial opioid agonist that can be prescribed by trained physicians and dispensed at pharmacies. This article addresses the clinical presentation of a patient with opioid dependence and describes the relatively new practice of office-based treatment with buprenorphine-naloxone. The different components of treatment; the role of the physician who provides this treatment; and the logistics of treating this growing, multifaceted patient population are also examined.
PP - United States
PY - 2008
SN - 1539-3704; 0003-4819
SP - 662
EP - 670
EP - 
T1 - Narrative review: Buprenorphine for opioid-dependent patients in office practice
T2 - Annals of Internal Medicine
TI - Narrative review: Buprenorphine for opioid-dependent patients in office practice
U1 - Opioids & Substance Use
U2 - 18458279
U3 - https://doi.org/10.7326/0003-4819-148-9-200805060-00006
VL - 148
VO - 1539-3704; 0003-4819
Y1 - 2008
ER -