TY - JOUR
KW - Adult
KW - Analgesics, Opioid/therapeutic use
KW - Buprenorphine/therapeutic use
KW - Female
KW - Humans
KW - Methadone/therapeutic use
KW - Opiate Substitution Treatment
KW - Opioid-Related Disorders/drug therapy
KW - Pregnancy
KW - Pregnancy Outcome
KW - Retrospective Studies
KW - Young Adult
AU - M. C. Meyer
AU - A. M. Johnston
AU - A. M. Crocker
AU - S. H. Heil
A1 - 
AB - OBJECTIVES: To compare maternal characteristics, prenatal care, and newborn outcomes in a cohort of opioid-dependent pregnant women treated with methadone versus buprenorphine. METHODS: In a retrospective cohort study, 609 pregnant, opioid-dependent women were treated with methadone (n = 248) or buprenorphine (n = 361) between 2000 and 2012 at a single institution. RESULTS: Mothers treated with buprenorphine were more likely to start medication before or earlier in pregnancy, had longer gestation, and gave birth to larger infants. Newborns of buprenorphine- versus methadone-maintained mothers required treatment for neonatal abstinence significantly less often and for a shorter duration. CONCLUSIONS: These data suggest pregnancy outcomes with buprenorphine to treat opioid dependence during pregnancy in clinical practice are as good and often better than outcomes with methadone. These results are consistent with efficacy data from randomized clinical trials and further support the use of buprenorphine for the treatment of opioid dependence during pregnancy.
BT - Journal of addiction medicine
C5 - Opioids & Substance Use
CP - 2
CY - United States
DO - 10.1097/ADM.0000000000000092
IS - 2
JF - Journal of addiction medicine
N2 - OBJECTIVES: To compare maternal characteristics, prenatal care, and newborn outcomes in a cohort of opioid-dependent pregnant women treated with methadone versus buprenorphine. METHODS: In a retrospective cohort study, 609 pregnant, opioid-dependent women were treated with methadone (n = 248) or buprenorphine (n = 361) between 2000 and 2012 at a single institution. RESULTS: Mothers treated with buprenorphine were more likely to start medication before or earlier in pregnancy, had longer gestation, and gave birth to larger infants. Newborns of buprenorphine- versus methadone-maintained mothers required treatment for neonatal abstinence significantly less often and for a shorter duration. CONCLUSIONS: These data suggest pregnancy outcomes with buprenorphine to treat opioid dependence during pregnancy in clinical practice are as good and often better than outcomes with methadone. These results are consistent with efficacy data from randomized clinical trials and further support the use of buprenorphine for the treatment of opioid dependence during pregnancy.
PP - United States
PY - 2015
SN - 1935-3227; 1932-0620
SP - 81
EP - 86
EP - 
T1 - Methadone and buprenorphine for opioid dependence during pregnancy: a retrospective cohort study
T2 - Journal of addiction medicine
TI - Methadone and buprenorphine for opioid dependence during pregnancy: a retrospective cohort study
U1 - Opioids & Substance Use
U2 - 25622120
U3 - 10.1097/ADM.0000000000000092
VL - 9
VO - 1935-3227; 1932-0620
Y1 - 2015
ER -