TY - JOUR
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Analgesics, Opioid/administration & dosage/adverse effects/therapeutic use
KW - Chronic Pain/drug therapy
KW - Delayed-Action Preparations
KW - Female
KW - Guideline Adherence
KW - Humans
KW - Male
KW - Middle Aged
KW - Morphine/administration & dosage/adverse effects/therapeutic use
KW - Opioid-Related Disorders/diagnosis/epidemiology/prevention & control
KW - Practice Guidelines as Topic
KW - Practice Patterns, Physicians'
KW - Primary Health Care
KW - Risk Assessment
KW - Risk Factors
KW - Substance Abuse Detection/methods
KW - Surveys and Questionnaires
KW - United States
KW - Young Adult
AU - J. Brown
AU - B. Setnik
AU - K. Lee
AU - L. Wase
AU - C. L. Roland
AU - J. M. Cleveland
AU - S. Siegel
AU - N. Katz
A1 - 
AB - OBJECTIVES: To evaluate potential for and incidence of aberrant drug-related behaviors among patients with chronic, moderate-to-severe pain in a primary care setting and to determine investigator compliance with universal precautions (UP) approach to pain management. DESIGN: Open label, multicenter. SETTING: Primary care centers (N = 281) across the United States. PATIENTS: Opioid naive and opioid experienced with chronic, moderate-to-severe pain (N = 1,487). INTERVENTIONS: Morphine sulfate extended-release capsules for  or = 75 percent of their patients. However, there was a tendency for investigators to assign risk levels for opioid misuse/abuse as lower than protocol specified. CONCLUSIONS: Most patients in these primary care study centers were categorized as at least moderate risk for opioid misuse/abuse at baseline. Most primary care investigators complied with the UP approach to pain management and risk assessment. The completion of the brief training and clinical use of the tools during the study led to retained behavior change, but there was a tendency for investigators to assign lower risk levels than those that were protocol-specified, suggesting a need for better understanding of factors influencing investigator decisions.
BT - Journal of opioid management
C5 - Opioids & Substance Use; Education & Workforce
CP - 6
CY - United States
IS - 6
JF - Journal of opioid management
N2 - OBJECTIVES: To evaluate potential for and incidence of aberrant drug-related behaviors among patients with chronic, moderate-to-severe pain in a primary care setting and to determine investigator compliance with universal precautions (UP) approach to pain management. DESIGN: Open label, multicenter. SETTING: Primary care centers (N = 281) across the United States. PATIENTS: Opioid naive and opioid experienced with chronic, moderate-to-severe pain (N = 1,487). INTERVENTIONS: Morphine sulfate extended-release capsules for  or = 75 percent of their patients. However, there was a tendency for investigators to assign risk levels for opioid misuse/abuse as lower than protocol specified. CONCLUSIONS: Most patients in these primary care study centers were categorized as at least moderate risk for opioid misuse/abuse at baseline. Most primary care investigators complied with the UP approach to pain management and risk assessment. The completion of the brief training and clinical use of the tools during the study led to retained behavior change, but there was a tendency for investigators to assign lower risk levels than those that were protocol-specified, suggesting a need for better understanding of factors influencing investigator decisions.
PP - United States
PY - 2011
SN - 1551-7489; 1551-7489
SP - 467
EP - 483
EP - 
T1 - Assessment, stratification, and monitoring of the risk for prescription opioid misuse and abuse in the primary care setting
T2 - Journal of opioid management
TI - Assessment, stratification, and monitoring of the risk for prescription opioid misuse and abuse in the primary care setting
U1 - Opioids & Substance Use; Education & Workforce
U2 - 22320029
VL - 7
VO - 1551-7489; 1551-7489
Y1 - 2011
ER -