TY - JOUR
KW - Adolescent
KW - Affective Symptoms/diagnosis/psychology/rehabilitation
KW - Ambulatory Care
KW - Behavior Therapy
KW - Buprenorphine/therapeutic use
KW - Clonidine/therapeutic use
KW - Combined Modality Therapy
KW - Comorbidity
KW - Double-Blind Method
KW - Drug Evaluation, Preclinical
KW - Female
KW - Humans
KW - Internal-External Control
KW - Male
KW - Mental Disorders/diagnosis/psychology/rehabilitation
KW - Opiate Substitution Treatment/methods
KW - Opioid-Related Disorders/rehabilitation
KW - Personality Inventory
KW - Token Economy
AU - S. K. Moore
AU - L. A. Marsch
AU - G. J. Badger
AU - R. Solhkhah
AU - Y. Hofstein
A1 - 
AB - OBJECTIVE: To examine changes in behavioral and emotional problems among opioid-dependent adolescents during a 4-week combined behavioral and pharmacological treatment. METHODS: We examined scales of behavioral and emotional problems in youth using the Youth Self-Report measure at the time of substance abuse treatment intake and changes in scale scores during treatment participants were 36 adolescents (aged 13-18 years, eligible) who met Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria for opioid dependence. Participants received a 28-day outpatient, medication-assisted withdrawal with either buprenorphine, or clonidine, as part of a double-blind, double dummy comparison of these medications. All participants received a common behavioral intervention, composed of 3 individual counseling sessions per week, and incentives contingent on opioid-negative urine samples (collected 3 times/week) attendance and completion of weekly assessments. RESULTS: Although a markedly greater number of youth who received buprenorphine remained in treatment relative to those who received clonidine, youth who remained in treatment showed significant reductions during treatment on 2 Youth Self-Report grouping scales (internalizing problems and total problems) and 4 of the empirically based syndrome scales (somatic, social, attention, and thought). On Youth Self-Report competence and adaptive scales, no significant changes were observed. There was no evidence that changes in any scales differed across medication condition. CONCLUSIONS: Youth who were retained demonstrated substantive improvements in a number of clinically meaningful behavioral and emotional problems, irrespective of pharmacotherapy provided to them.
BT - Journal of addiction medicine
C5 - Opioids & Substance Use; Healthcare Disparities
CP - 4
CY - United States
DO - 10.1097/ADM.0b013e3182191099
IS - 4
JF - Journal of addiction medicine
N2 - OBJECTIVE: To examine changes in behavioral and emotional problems among opioid-dependent adolescents during a 4-week combined behavioral and pharmacological treatment. METHODS: We examined scales of behavioral and emotional problems in youth using the Youth Self-Report measure at the time of substance abuse treatment intake and changes in scale scores during treatment participants were 36 adolescents (aged 13-18 years, eligible) who met Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria for opioid dependence. Participants received a 28-day outpatient, medication-assisted withdrawal with either buprenorphine, or clonidine, as part of a double-blind, double dummy comparison of these medications. All participants received a common behavioral intervention, composed of 3 individual counseling sessions per week, and incentives contingent on opioid-negative urine samples (collected 3 times/week) attendance and completion of weekly assessments. RESULTS: Although a markedly greater number of youth who received buprenorphine remained in treatment relative to those who received clonidine, youth who remained in treatment showed significant reductions during treatment on 2 Youth Self-Report grouping scales (internalizing problems and total problems) and 4 of the empirically based syndrome scales (somatic, social, attention, and thought). On Youth Self-Report competence and adaptive scales, no significant changes were observed. There was no evidence that changes in any scales differed across medication condition. CONCLUSIONS: Youth who were retained demonstrated substantive improvements in a number of clinically meaningful behavioral and emotional problems, irrespective of pharmacotherapy provided to them.
PP - United States
PY - 2011
SN - 1932-0620; 1932-0620
SP - 264
EP - 271
EP - 
T1 - Improvement in psychopathology among opioid-dependent adolescents during behavioral-pharmacological treatment
T2 - Journal of addiction medicine
TI - Improvement in psychopathology among opioid-dependent adolescents during behavioral-pharmacological treatment
U1 - Opioids & Substance Use; Healthcare Disparities
U2 - 22107875
U3 - 10.1097/ADM.0b013e3182191099
VL - 5
VO - 1932-0620; 1932-0620
Y1 - 2011
ER -