TY - JOUR
KW - Adult
KW - Analgesics, Opioid/administration & dosage
KW - Brain/drug effects/physiopathology
KW - Cognitive dysfunction
KW - Electroencephalography/drug effects/methods
KW - Evoked Potentials, Auditory/drug effects/physiology
KW - Female
KW - Heroin Dependence/drug therapy/physiopathology/psychology
KW - Humans
KW - Male
KW - Methadone maintenance treatment (MMT)
KW - Methadone/administration & dosage
KW - Middle Aged
KW - Neuro-electrophysiology
KW - Spatial-spectral analysis
KW - Treatment Outcome
KW - Young Adult
AU - F. Motlagh
AU - F. Ibrahim
AU - R. Rashid
AU - N. Shafiabady
AU - T. Seghatoleslam
AU - H. Habil
A1 - 
AB - Methadone as the most prevalent opioid substitution medication has been shown to influence the neurophysiological functions among heroin addicts. However, there is no firm conclusion on acute neuroelectrophysiological changes among methadone-treated subjects as well as the effectiveness of methadone in restoring brain electrical abnormalities among heroin addicts. This study aims to investigate the acute and short-term effects of methadone administration on the brain's electrophysiological properties before and after daily methadone intake over 10 weeks of treatment among heroin addicts. EEG spectral analysis and single-trial event-related potential (ERP) measurements were used to investigate possible alterations in the brain's electrical activities, as well as the cognitive attributes associated with MMN and P3. The results confirmed abnormal brain activities predominantly in the beta band and diminished information processing ability including lower amplitude and prolonged latency of cognitive responses among heroin addicts compared to healthy controls. In addition, the alteration of EEG activities in the frontal and central regions was found to be associated with the withdrawal symptoms of drug users. Certain brain regions were found to be influenced significantly by methadone intake; acute effects of methadone induction appeared to be associative to its dosage. The findings suggest that methadone administration affects cognitive performance and activates the cortical neuronal networks, resulting in cognitive responses enhancement which may be influential in reorganizing cognitive dysfunctions among heroin addicts. This study also supports the notion that the brain's oscillation powers and ERPs can be utilized as neurophysiological indices for assessing the addiction treatment traits.
BT - Psychopharmacology
C5 - Measures; Opioids & Substance Use
CP - 11
CY - Germany
DO - 10.1007/s00213-018-5035-0
IS - 11
JF - Psychopharmacology
N2 - Methadone as the most prevalent opioid substitution medication has been shown to influence the neurophysiological functions among heroin addicts. However, there is no firm conclusion on acute neuroelectrophysiological changes among methadone-treated subjects as well as the effectiveness of methadone in restoring brain electrical abnormalities among heroin addicts. This study aims to investigate the acute and short-term effects of methadone administration on the brain's electrophysiological properties before and after daily methadone intake over 10 weeks of treatment among heroin addicts. EEG spectral analysis and single-trial event-related potential (ERP) measurements were used to investigate possible alterations in the brain's electrical activities, as well as the cognitive attributes associated with MMN and P3. The results confirmed abnormal brain activities predominantly in the beta band and diminished information processing ability including lower amplitude and prolonged latency of cognitive responses among heroin addicts compared to healthy controls. In addition, the alteration of EEG activities in the frontal and central regions was found to be associated with the withdrawal symptoms of drug users. Certain brain regions were found to be influenced significantly by methadone intake; acute effects of methadone induction appeared to be associative to its dosage. The findings suggest that methadone administration affects cognitive performance and activates the cortical neuronal networks, resulting in cognitive responses enhancement which may be influential in reorganizing cognitive dysfunctions among heroin addicts. This study also supports the notion that the brain's oscillation powers and ERPs can be utilized as neurophysiological indices for assessing the addiction treatment traits.
PP - Germany
PY - 2018
SN - 1432-2072; 0033-3158
SP - 3273
EP - 3288
EP - 
T1 - Acute effects of methadone on EEG power spectrum and event-related potentials among heroin dependents
T2 - Psychopharmacology
TI - Acute effects of methadone on EEG power spectrum and event-related potentials among heroin dependents
U1 - Measures; Opioids & Substance Use
U2 - 30310960
U3 - 10.1007/s00213-018-5035-0
VL - 235
VO - 1432-2072; 0033-3158
Y1 - 2018
ER -